The effects of flumazenil on sedation, and disturbance of equilibrium function by midazolam

The purpose of this study was to evaluate the effects and side effects of flumazenil on Midazolam. Seven healthy adult volunteers received Midazolam 0.075 mg/kg and, thirty minutes later, flumazenil 0.5 mg intravenously. Another group received only midazolam. The degree of sedation was assessed at 0, 30 minutes after administration of midazolam, and 0, 15, 30, 45, 60, 75, 90, 105, 120, 135, and 150 minutes after administration of flumazenil. The qualitative equilibrium function test, one-leg test, and Mann's test were used. As the quantitative equilibrium function test, the length per second and the area of bodysway were measured. These tests were done before midazolam and at 0, 30, 60, 90, 120 and 150 minutes after flumazenil (Fig. 1). All tests were performed with eyes both open and closed. Flumazenil antagonized the disturbance of equilibrium function as well as the sedation caused by midazolam. No case experienced deep resedation (Fig. 2, 3). However the disturbance caused by midazolam remained; they were found to be disturbed for 60 minutes after administration of flumazenil. Flumazenil changed the course of recovery from that with midazolam only (Fig. 4-11). Patients must be observed for at least 60 minutes after flumazenil is administered, and time is required for a perfect recovery.