Abstract
The purpose of this study was to evaluate the effects and side effects of flumazenil on midazolam. Eight healthy adult volunteers received midazolam 0.075 mg/kg and, five minutes later, flumazenil 0.5 mg intravenously. The degree of sedation was assessed at 0 and 5 minutes after administration of midazolam, and at 0, 15, 30, 45, 60, 75, 90, 105, 120, 135, and 150 minutes after administration of flumazenil. The qualitative equilibrium function tests, Mann's test and the one leg test were used. As the quantitative equilibrium function test, the length per second and the area of body sway were measured. These tests were done before midazolam and at 0, 30, 60, 90, 120 and 150 minutes after flumazenil. All tests were performed with eyes both open and closed. Flumazenil 0.5 mg/kg could not fully antagonize the sedation caused by midazolam in two cases. Sixty minutes after administration of flumazenil, four cases were sedated. No case experienced deep resedation after flumazenil. Disturbance of equilibrium function appeared strongly for thirty minutes after administration of flumazenil, so even awakened cases must continue to be observed. When flumazenil is administered to counteract a deep level of sedation by midazolam, patients must be observed for at least sixty minutes after administration of flumazenil.
| Original language | English |
|---|---|
| Pages (from-to) | 111-118 |
| Number of pages | 8 |
| Journal | Journal of Japanese Dental Society of Anesthesiology |
| Volume | 23 |
| Issue number | 1 |
| Publication status | Published - 1995 |
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Keywords
- equilibrium function
- flumazenil
- intravenous sedation
- midazolam
- recovery
ASJC Scopus subject areas
- Anesthesiology and Pain Medicine
Cite this
The effects of flumazenil on sedation and disturbance of equilibrium function by midazolam : Part 2. / Maeda, Shigeru; Miyawaki, Takuya; Shimada, M.
In: Journal of Japanese Dental Society of Anesthesiology, Vol. 23, No. 1, 1995, p. 111-118.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - The effects of flumazenil on sedation and disturbance of equilibrium function by midazolam
T2 - Part 2
AU - Maeda, Shigeru
AU - Miyawaki, Takuya
AU - Shimada, M.
PY - 1995
Y1 - 1995
N2 - The purpose of this study was to evaluate the effects and side effects of flumazenil on midazolam. Eight healthy adult volunteers received midazolam 0.075 mg/kg and, five minutes later, flumazenil 0.5 mg intravenously. The degree of sedation was assessed at 0 and 5 minutes after administration of midazolam, and at 0, 15, 30, 45, 60, 75, 90, 105, 120, 135, and 150 minutes after administration of flumazenil. The qualitative equilibrium function tests, Mann's test and the one leg test were used. As the quantitative equilibrium function test, the length per second and the area of body sway were measured. These tests were done before midazolam and at 0, 30, 60, 90, 120 and 150 minutes after flumazenil. All tests were performed with eyes both open and closed. Flumazenil 0.5 mg/kg could not fully antagonize the sedation caused by midazolam in two cases. Sixty minutes after administration of flumazenil, four cases were sedated. No case experienced deep resedation after flumazenil. Disturbance of equilibrium function appeared strongly for thirty minutes after administration of flumazenil, so even awakened cases must continue to be observed. When flumazenil is administered to counteract a deep level of sedation by midazolam, patients must be observed for at least sixty minutes after administration of flumazenil.
AB - The purpose of this study was to evaluate the effects and side effects of flumazenil on midazolam. Eight healthy adult volunteers received midazolam 0.075 mg/kg and, five minutes later, flumazenil 0.5 mg intravenously. The degree of sedation was assessed at 0 and 5 minutes after administration of midazolam, and at 0, 15, 30, 45, 60, 75, 90, 105, 120, 135, and 150 minutes after administration of flumazenil. The qualitative equilibrium function tests, Mann's test and the one leg test were used. As the quantitative equilibrium function test, the length per second and the area of body sway were measured. These tests were done before midazolam and at 0, 30, 60, 90, 120 and 150 minutes after flumazenil. All tests were performed with eyes both open and closed. Flumazenil 0.5 mg/kg could not fully antagonize the sedation caused by midazolam in two cases. Sixty minutes after administration of flumazenil, four cases were sedated. No case experienced deep resedation after flumazenil. Disturbance of equilibrium function appeared strongly for thirty minutes after administration of flumazenil, so even awakened cases must continue to be observed. When flumazenil is administered to counteract a deep level of sedation by midazolam, patients must be observed for at least sixty minutes after administration of flumazenil.
KW - equilibrium function
KW - flumazenil
KW - intravenous sedation
KW - midazolam
KW - recovery
UR - http://www.scopus.com/inward/record.url?scp=0028804532&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0028804532&partnerID=8YFLogxK
M3 - Article
AN - SCOPUS:0028804532
VL - 23
SP - 111
EP - 118
JO - Journal of Japanese Dental Society of Anesthesiology
JF - Journal of Japanese Dental Society of Anesthesiology
SN - 0386-5835
IS - 1
ER -