The effects of flumazenil on sedation, amnesia, and disturbance of equilibrium function by diazepam

Shigeru Maeda, M. Shimada, T. Miyawaki, E. Koyama, K. Nishijima

Research output: Contribution to journalArticlepeer-review


The purpose of the study is to evaluate the effects and side effects of flumazenil on diazepam. Twenty healthy adult volunteers were studied in a double-blind trial. They received diazepam 0.3 mg/kg and, thirty minutes later, flumazenil or saline intravenously. The degree of sedation was assessed at 0, 5, 10, 15, and 25 min. after administration of diazepam and 5, 10, 15, 30, 60, 90, and 120 min. after administration of the test drug. Amnesia was tested by showing them a cup, a pen, or a watch before diazepam and 5 min. after flumazenil. After experiment they were asked what they had seen. Equilibrium function was measured by Romberg's test, One-leg test, Mann's test, and Standing-on-disc test before diazepam and at 5, 30, 60, 90 and 120 min. after flumazenil. All tests except the Standing-on-disk test were performed with eyes both open and closed. Flumazenil significantly reduced the number of sedative cases at 90 min. Resedation was experienced by four cases in the flumazenil group, but the degree was not very deep. Amnesia was found in one in the flumazenil group, compared with seven in the saline group; this is significant. There were significant differences in the number of recovery subjects at 5 and 30 min. in Romberg's test (eyes open), 5 min. in Romberg's test (eyes closed), 5, 30, and 60 min. Mann' test (eyes open), 60 min. in Mann's test (eyes closed), 60 min. in One-leg test, and 90 and 120 min. in Standing-on-disk test. At 120 min. after administration of flumazenil, in Mann's test (eyes open) the recovery was not complete after flumazenil. No side efects related to flumazenil were observed. The present study indicates that flumazenil quickly and effectively antagonizes sedation, amnesia, and disturbance of equilibrium function caused by diazepam, but more time is required for a perfect recovery of equilibrium function.

Original languageEnglish
Pages (from-to)407-416
Number of pages10
JournalJournal of Japanese Dental Society of Anesthesiology
Issue number2
Publication statusPublished - 1993


  • diazepam
  • equilibrium function
  • flumazenil
  • intravenous sedation
  • recovery

ASJC Scopus subject areas

  • Dentistry(all)
  • Anesthesiology and Pain Medicine


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