Abstract
Although epidural anesthesia prevents immune suppression during surgery, no reports have elucidated how epidural block affects immune response in nonsurgical patients. We examined changes in proportion of lymphocyte subsets and in natural-killer (NK) cell activity in patients with and without pain. Fifteen patients with pain (Pain group) and 15 preoperative patients without pain (Preoperative group) received three different treatments in random order: epidural block with 7 mL 1% lidocaine, epidural injection of an identical volume of normal saline, and IV injection of 1 mg/kg lidocaine. Blood samples were drawn before and after 30, 60, and 120 min of treatment. During epidural block at 30 and 60 min, both groups showed significantly decreased epinephrine, norepinephrine, and cortisol levels, and the proportion of NK cells decreased, whereas the CD4+/CD8+ ratio increased significantly. NK cell activity in both groups decreased significantly at 30 and 60 min. At 120 min, the variables had all returned to preblock values. During treatments with saline and IV lidocaine, neither group showed significant changes in any of the above variables. We conclude that epidural block causes a transient and significant alteration of lymphocyte subsets and NK cell activity regardless of pain status.
| Original language | English |
|---|---|
| Pages (from-to) | 463-469 |
| Number of pages | 7 |
| Journal | Anesthesia and Analgesia |
| Volume | 92 |
| Issue number | 2 |
| Publication status | Published - 2001 |
Fingerprint
ASJC Scopus subject areas
- Anesthesiology and Pain Medicine
Cite this
The effects of epidural block on the distribution of lymphocyte subsets and natural-killer cell activity in patients with and without pain. / Yokoyama, Masataka; Itano, Yoshitaro; Mizobuchi, Satoshi; Nakatsuka, Hideki; Kaku, Ryuji; Takashima, Takeaki; Hirakawa, Masahisa.
In: Anesthesia and Analgesia, Vol. 92, No. 2, 2001, p. 463-469.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - The effects of epidural block on the distribution of lymphocyte subsets and natural-killer cell activity in patients with and without pain
AU - Yokoyama, Masataka
AU - Itano, Yoshitaro
AU - Mizobuchi, Satoshi
AU - Nakatsuka, Hideki
AU - Kaku, Ryuji
AU - Takashima, Takeaki
AU - Hirakawa, Masahisa
PY - 2001
Y1 - 2001
N2 - Although epidural anesthesia prevents immune suppression during surgery, no reports have elucidated how epidural block affects immune response in nonsurgical patients. We examined changes in proportion of lymphocyte subsets and in natural-killer (NK) cell activity in patients with and without pain. Fifteen patients with pain (Pain group) and 15 preoperative patients without pain (Preoperative group) received three different treatments in random order: epidural block with 7 mL 1% lidocaine, epidural injection of an identical volume of normal saline, and IV injection of 1 mg/kg lidocaine. Blood samples were drawn before and after 30, 60, and 120 min of treatment. During epidural block at 30 and 60 min, both groups showed significantly decreased epinephrine, norepinephrine, and cortisol levels, and the proportion of NK cells decreased, whereas the CD4+/CD8+ ratio increased significantly. NK cell activity in both groups decreased significantly at 30 and 60 min. At 120 min, the variables had all returned to preblock values. During treatments with saline and IV lidocaine, neither group showed significant changes in any of the above variables. We conclude that epidural block causes a transient and significant alteration of lymphocyte subsets and NK cell activity regardless of pain status.
AB - Although epidural anesthesia prevents immune suppression during surgery, no reports have elucidated how epidural block affects immune response in nonsurgical patients. We examined changes in proportion of lymphocyte subsets and in natural-killer (NK) cell activity in patients with and without pain. Fifteen patients with pain (Pain group) and 15 preoperative patients without pain (Preoperative group) received three different treatments in random order: epidural block with 7 mL 1% lidocaine, epidural injection of an identical volume of normal saline, and IV injection of 1 mg/kg lidocaine. Blood samples were drawn before and after 30, 60, and 120 min of treatment. During epidural block at 30 and 60 min, both groups showed significantly decreased epinephrine, norepinephrine, and cortisol levels, and the proportion of NK cells decreased, whereas the CD4+/CD8+ ratio increased significantly. NK cell activity in both groups decreased significantly at 30 and 60 min. At 120 min, the variables had all returned to preblock values. During treatments with saline and IV lidocaine, neither group showed significant changes in any of the above variables. We conclude that epidural block causes a transient and significant alteration of lymphocyte subsets and NK cell activity regardless of pain status.
UR - http://www.scopus.com/inward/record.url?scp=0035145969&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0035145969&partnerID=8YFLogxK
M3 - Article
VL - 92
SP - 463
EP - 469
JO - Anesthesia and Analgesia
JF - Anesthesia and Analgesia
SN - 0003-2999
IS - 2
ER -