The effects of epidural block on the distribution of lymphocyte subsets and natural-killer cell activity in patients with and without pain

Masataka Yokoyama, Yoshitaro Itano, Satoshi Mizobuchi, Hideki Nakatsuka, Ryuji Kaku, Takeaki Takashima, Masahisa Hirakawa

Research output: Contribution to journalArticle

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Abstract

Although epidural anesthesia prevents immune suppression during surgery, no reports have elucidated how epidural block affects immune response in nonsurgical patients. We examined changes in proportion of lymphocyte subsets and in natural-killer (NK) cell activity in patients with and without pain. Fifteen patients with pain (Pain group) and 15 preoperative patients without pain (Preoperative group) received three different treatments in random order: epidural block with 7 mL 1% lidocaine, epidural injection of an identical volume of normal saline, and IV injection of 1 mg/kg lidocaine. Blood samples were drawn before and after 30, 60, and 120 min of treatment. During epidural block at 30 and 60 min, both groups showed significantly decreased epinephrine, norepinephrine, and cortisol levels, and the proportion of NK cells decreased, whereas the CD4+/CD8+ ratio increased significantly. NK cell activity in both groups decreased significantly at 30 and 60 min. At 120 min, the variables had all returned to preblock values. During treatments with saline and IV lidocaine, neither group showed significant changes in any of the above variables. We conclude that epidural block causes a transient and significant alteration of lymphocyte subsets and NK cell activity regardless of pain status.

Original languageEnglish
Pages (from-to)463-469
Number of pages7
JournalAnesthesia and Analgesia
Volume92
Issue number2
Publication statusPublished - 2001

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Lymphocyte Subsets
Natural Killer Cells
Pain
Lidocaine
Epidural Injections
CD4-CD8 Ratio
Epidural Anesthesia
Epinephrine
Hydrocortisone
Norepinephrine
Therapeutics
Injections

ASJC Scopus subject areas

  • Anesthesiology and Pain Medicine

Cite this

The effects of epidural block on the distribution of lymphocyte subsets and natural-killer cell activity in patients with and without pain. / Yokoyama, Masataka; Itano, Yoshitaro; Mizobuchi, Satoshi; Nakatsuka, Hideki; Kaku, Ryuji; Takashima, Takeaki; Hirakawa, Masahisa.

In: Anesthesia and Analgesia, Vol. 92, No. 2, 2001, p. 463-469.

Research output: Contribution to journalArticle

Yokoyama, M, Itano, Y, Mizobuchi, S, Nakatsuka, H, Kaku, R, Takashima, T & Hirakawa, M 2001, 'The effects of epidural block on the distribution of lymphocyte subsets and natural-killer cell activity in patients with and without pain', Anesthesia and Analgesia, vol. 92, no. 2, pp. 463-469.
Yokoyama, Masataka ; Itano, Yoshitaro ; Mizobuchi, Satoshi ; Nakatsuka, Hideki ; Kaku, Ryuji ; Takashima, Takeaki ; Hirakawa, Masahisa. / The effects of epidural block on the distribution of lymphocyte subsets and natural-killer cell activity in patients with and without pain. In: Anesthesia and Analgesia. 2001 ; Vol. 92, No. 2. pp. 463-469.
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