TY - JOUR
T1 - The effects of body weight and combination drug therapy on the serum concentrations of zonisamide in 94 epileptic dogs
T2 - An epidemiological analysis
AU - Fukunaga, Koya
AU - Aiba, Tetsuya
AU - Saito, Miyoko
AU - Muto, Makoto
AU - Watanabe, Naoyuki
AU - Uchida, Keiko
AU - Okuno, Seiichi
AU - Kobayashi, Takayuki
AU - Orito, Kensuke
N1 - Copyright:
Copyright 2013 Elsevier B.V., All rights reserved.
PY - 2012
Y1 - 2012
N2 - To clarify the effects of background factors such as body weight, combination drug therapy with phenobarbital (PB) and potassium bromide (KBr), age, gender, neuter status, and blood collection time on the serum concentrations of zonisamide (ZNS) in 94 epileptic dogs, serum ZNS concentrations of 141 samples from 94 epileptic dogs were measured by high-performance liquid chromatography with UV detection. Serum ZNS concentrations were divided by the dosage of ZNS, to obtain normalized ZNS concentrations. Multiple linear regression analysis revealed that body weight and combination therapies with KBr, PB, and KBr + PB affected the normalized ZNS concentrations, and normalized ZNS concentrations were positively correlated with body weight. The normalized ZNS concentrations in dogs with PB combination therapy were lower when compared with those concentrations in dogs receiving ZNS alone, but were higher in dogs receiving KBr combination therapy. These results suggest that serum ZNS concentrations are influenced by body weight and combination drug therapies using KBr, PB, and KBr + PB. This information of ZNS characteristics may be useful in determining the initial and modified doses of ZNS in the therapy of epileptic dogs. and half-life of ZNS. However, such factors have not been evaluated so far in epileptic dogs. The present study quantitatively examined whether body weight and PB and/ or KBr combination drug therapies altered ZNS concentrations by using an epidemiological method.
AB - To clarify the effects of background factors such as body weight, combination drug therapy with phenobarbital (PB) and potassium bromide (KBr), age, gender, neuter status, and blood collection time on the serum concentrations of zonisamide (ZNS) in 94 epileptic dogs, serum ZNS concentrations of 141 samples from 94 epileptic dogs were measured by high-performance liquid chromatography with UV detection. Serum ZNS concentrations were divided by the dosage of ZNS, to obtain normalized ZNS concentrations. Multiple linear regression analysis revealed that body weight and combination therapies with KBr, PB, and KBr + PB affected the normalized ZNS concentrations, and normalized ZNS concentrations were positively correlated with body weight. The normalized ZNS concentrations in dogs with PB combination therapy were lower when compared with those concentrations in dogs receiving ZNS alone, but were higher in dogs receiving KBr combination therapy. These results suggest that serum ZNS concentrations are influenced by body weight and combination drug therapies using KBr, PB, and KBr + PB. This information of ZNS characteristics may be useful in determining the initial and modified doses of ZNS in the therapy of epileptic dogs. and half-life of ZNS. However, such factors have not been evaluated so far in epileptic dogs. The present study quantitatively examined whether body weight and PB and/ or KBr combination drug therapies altered ZNS concentrations by using an epidemiological method.
KW - Epidemiological analysis
KW - Epileptic dogs
KW - Zonisamide concentrations
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M3 - Article
AN - SCOPUS:84874080988
VL - 10
SP - 258
EP - 263
JO - International Journal of Applied Research in Veterinary Medicine
JF - International Journal of Applied Research in Veterinary Medicine
SN - 1542-2666
IS - 3
ER -