The effect of Si(IV) species derived from chitosan-silicate hydrogels on osteoblast behavior

Yuki Shirosaki, Satoshi Hayakawa, Akiyoshi Osaka

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Citation (Scopus)

Abstract

Chitosan-GPTMS (γ-Glycidoxypropyltrimethoxysilane) hybrid hydrogels were synthesized with β-glycerophosphate (β-GP) as the additive agent. Chitosan-GPTMS sols were fluid at room temperature and transformed to hydrogel at 36.5°C in several min. The gelation time of the hydrogels was shortened by the addition of GPTMS. From NMR experiments, this gelation behavior depended on some factors, namely, electrostatic interaction between the phosphate groups of β-GP and the amino groups of chitosan chains, crosslinking between the epoxy groups of GPTMS and the amino groups of chitosan, and polycondensation of the methoxy groups of GPTMS. The Si(IV) released from the hydrogels promoted the cell adhesion and ALP activity of osteoblastic cells MG63.

Original languageEnglish
Title of host publicationBioceramics 23
Pages698-702
Number of pages5
DOIs
Publication statusPublished - Jan 1 2012
Event23rd Symposium and Annual Meeting of International Society for Ceramics in Medicine, ISCM 2011 - Istanbul, Turkey
Duration: Nov 6 2011Nov 9 2011

Publication series

NameKey Engineering Materials
Volume493-494
ISSN (Print)1013-9826

Other

Other23rd Symposium and Annual Meeting of International Society for Ceramics in Medicine, ISCM 2011
CountryTurkey
CityIstanbul
Period11/6/1111/9/11

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Keywords

  • Chitosan
  • Hydrogel
  • Organic-inorganic hybrid
  • Osteoblast
  • Si(IV) species

ASJC Scopus subject areas

  • Materials Science(all)
  • Mechanics of Materials
  • Mechanical Engineering

Cite this

Shirosaki, Y., Hayakawa, S., & Osaka, A. (2012). The effect of Si(IV) species derived from chitosan-silicate hydrogels on osteoblast behavior. In Bioceramics 23 (pp. 698-702). (Key Engineering Materials; Vol. 493-494). https://doi.org/10.4028/www.scientific.net/KEM.493-494.698