The effect of L-Glutamine and Shakuyaku-Kanzo-to for paclitaxel-induced myalgia/arthralgia

Kosei Hasegawa, Yasushi Mizutani, Hiroyuki Kuramoto, Shoji Nagao, Hisashi Masuyama, Atsuhi Hongo, Jyunichi Kodama, Mitsuo Yoshinouchi, Yuji Hiramatsu, Takafumi Kudo, Hiroyuki Okuda

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Myalgia/arthralgia is a crucial side effect of paclitaxel, and may become the major dose-limiting side effect. However, this is a situation where there is little effective preventive treatment. L-Glutamine was reported as a neuroprotective agent for vincristine-induced neurotoxicity. In Japan, there have been reports on steroid and Shakuyaku-Kanzou-to (a herbal medicine) for paclitaxel-induced myalgia/arthralgia. This study aimed to compare the effect of L-Glutamine and Shakuyaku-Kanzou-to, and to discuss the validity of these agents for the paclitaxel-induced myalgia/arthralgia. Our results suggested that Shakuyaku-Kanzou-to showed no remarkable effects against paclitaxel-induced myalgia/arthralgia as had been reported before; however, both L-Glutamine and Shakuyaku-Kanzou-to decreased the duration of grade 2 toxicity (CALGB Expanded Common Toxicity Criteria) in comparison with those who were not treated. L-Glutamine and Shakuyaku-Kanzou-to might therefore a preventive effect against moderate or severer myalgia/arthralgia during paclitaxel-treated chemotherapy. Further trials are needed to confirm the value of these drugs.

Original languageEnglish
Pages (from-to)569-574
Number of pages6
JournalGan to kagaku ryoho. Cancer & chemotherapy
Volume29
Issue number4
Publication statusPublished - Apr 2002

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Paeonia
Myalgia
Arthralgia
Paclitaxel
Glutamine
Herbal Medicine
Vincristine
Neuroprotective Agents
Japan
Steroids
shakuyaku-kanzoh-toh
Drug Therapy
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Cancer Research
  • Pharmacology

Cite this

Hasegawa, K., Mizutani, Y., Kuramoto, H., Nagao, S., Masuyama, H., Hongo, A., ... Okuda, H. (2002). The effect of L-Glutamine and Shakuyaku-Kanzo-to for paclitaxel-induced myalgia/arthralgia. Gan to kagaku ryoho. Cancer & chemotherapy, 29(4), 569-574.

The effect of L-Glutamine and Shakuyaku-Kanzo-to for paclitaxel-induced myalgia/arthralgia. / Hasegawa, Kosei; Mizutani, Yasushi; Kuramoto, Hiroyuki; Nagao, Shoji; Masuyama, Hisashi; Hongo, Atsuhi; Kodama, Jyunichi; Yoshinouchi, Mitsuo; Hiramatsu, Yuji; Kudo, Takafumi; Okuda, Hiroyuki.

In: Gan to kagaku ryoho. Cancer & chemotherapy, Vol. 29, No. 4, 04.2002, p. 569-574.

Research output: Contribution to journalArticle

Hasegawa, K, Mizutani, Y, Kuramoto, H, Nagao, S, Masuyama, H, Hongo, A, Kodama, J, Yoshinouchi, M, Hiramatsu, Y, Kudo, T & Okuda, H 2002, 'The effect of L-Glutamine and Shakuyaku-Kanzo-to for paclitaxel-induced myalgia/arthralgia', Gan to kagaku ryoho. Cancer & chemotherapy, vol. 29, no. 4, pp. 569-574.
Hasegawa, Kosei ; Mizutani, Yasushi ; Kuramoto, Hiroyuki ; Nagao, Shoji ; Masuyama, Hisashi ; Hongo, Atsuhi ; Kodama, Jyunichi ; Yoshinouchi, Mitsuo ; Hiramatsu, Yuji ; Kudo, Takafumi ; Okuda, Hiroyuki. / The effect of L-Glutamine and Shakuyaku-Kanzo-to for paclitaxel-induced myalgia/arthralgia. In: Gan to kagaku ryoho. Cancer & chemotherapy. 2002 ; Vol. 29, No. 4. pp. 569-574.
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