The effect of initial treatment on hearing prognosis in idiopathic sudden sensorineural hearing loss: a nationwide survey in Japan

Masahiro Okada, Naohito Hato, Shin Ya Nishio, Ryosuke Kitoh, Kaoru Ogawa, Sho Kanzaki, Michihiko Sone, Satoshi Fukuda, Akira Hara, Tetsuo Ikezono, Kotaro Ishikawa, Satoshi Iwasaki, Kimitaka Kaga, Seiji Kakehata, Atsushi Matsubara, Tatsuo Matsunaga, Takaaki Murata, Yasushi Naito, Takashi Nakagawa, Kazunori NishizakiYoshihiro Noguchi, Hajime Sano, Hiroaki Sato, Mikio Suzuki, Hideo Shojaku, Haruo Takahashi, Hidehiko Takeda, Tetsuya Tono, Hiroshi Yamashita, Tatsuya Yamasoba, Shin Ichi Usami

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Objective: To investigate the hearing prognosis of idiopathic sudden sensorineural hearing loss (SSNHL) treated with different initial therapies. Methods: Subjects consisted of patients diagnosed with idiopathic SSNHL within 7 days from onset and showing severe hearing loss (≥60 dB), who were registered in a Japanese multicenter database between April 2014 and March 2016. Subjects were divided into four groups according to initial therapy: (1) steroids, (2) steroids + Prostaglandins (PGs), (3) intratympanic steroids (ITS), and (4) no steroids. Hearing outcomes were compared among the groups. Results: In total, 1305 patients were enrolled. The final hearing level and hearing gain of patients treated with steroids + PGs were significantly higher than those of patients treated with steroids alone or no steroids. The ratio of good prognosis (complete recovery or marked improvement) in patients treated with steroids + PGs was higher than that in patients treated with steroids alone or no steroids. There was no difference in the prognosis of patients treated with steroids alone or no steroids. Conclusion: A large number of patients with idiopathic SSNHL were registered in a multicenter database. PG use in combination with steroid administration was associated with a good hearing prognosis in patients with severe hearing loss.

Original languageEnglish
Pages (from-to)S30-S33
JournalActa Oto-Laryngologica
Volume137
DOIs
Publication statusPublished - Mar 10 2017

Keywords

  • Idiopathic sudden sensorineural hearing
  • intratympanic steroid injection
  • prostaglandin
  • steroid

ASJC Scopus subject areas

  • Otorhinolaryngology

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    Okada, M., Hato, N., Nishio, S. Y., Kitoh, R., Ogawa, K., Kanzaki, S., Sone, M., Fukuda, S., Hara, A., Ikezono, T., Ishikawa, K., Iwasaki, S., Kaga, K., Kakehata, S., Matsubara, A., Matsunaga, T., Murata, T., Naito, Y., Nakagawa, T., ... Usami, S. I. (2017). The effect of initial treatment on hearing prognosis in idiopathic sudden sensorineural hearing loss: a nationwide survey in Japan. Acta Oto-Laryngologica, 137, S30-S33. https://doi.org/10.1080/00016489.2017.1296970