The effect of growth factors for bone augmentation to enable dental implant placement

A systematic review

Kengo Shimono, Masamitsu Oshima, Hikaru Arakawa, Aya Ono, Kumiko Nawachi, Takuo Kuboki

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

This systematic review assessed the potential benefits of growth factors for bone augmentation prior to the placement of dental implants in human. A systematic online review of the Medline database, using the PubMed search machine was performed between 1966 and November 2008 by entering the MeSH terms. The primary outcome of the included studies was bone regeneration of localized alveolar ridge defects. The initial search identified 119 papers from the electronic database. This review produced seven eligible papers that reported on bone augmentation with recombinant human Bone Morphogenetic Protein-2 (rhBMP-2), recombinant human Platelet-Derived Growth Factor (rhPDGF) and Plasma-Rich Growth Factor (PRGF). The rhBMP-2 affected local bone augmentation with increasing volume for higher doses. Both rhPDGF and PRGF showed a positive effect in favor of the growth factor. Differing levels and quantity of evidence were noted to be available for the growth factors evaluated, revealing that rhBMP-2, rhPDGF, and PRGF may stimulate local bone augmentation to various conditions. Especially the potential of rhBMP-2 is supportive. However, the confined number of investigators using these techniques and the low number of patient treatments reported in the literature, the generalizability of this approach is limited at this time.

Original languageEnglish
Pages (from-to)43-53
Number of pages11
JournalJapanese Dental Science Review
Volume46
Issue number1
DOIs
Publication statusPublished - Feb 2010

Fingerprint

Dental Implants
Intercellular Signaling Peptides and Proteins
Bone and Bones
Platelet-Derived Growth Factor
Databases
Alveolar Process
Bone Regeneration
PubMed
Research Personnel
Outcome Assessment (Health Care)
recombinant human bone morphogenetic protein-2

Keywords

  • Bone augmentation
  • Clinical trial
  • Dental implant
  • Growth factors
  • Systematic review

ASJC Scopus subject areas

  • Dentistry(all)

Cite this

The effect of growth factors for bone augmentation to enable dental implant placement : A systematic review. / Shimono, Kengo; Oshima, Masamitsu; Arakawa, Hikaru; Ono, Aya; Nawachi, Kumiko; Kuboki, Takuo.

In: Japanese Dental Science Review, Vol. 46, No. 1, 02.2010, p. 43-53.

Research output: Contribution to journalArticle

@article{b87fc356a01f4a5ca78952c12f0a49c9,
title = "The effect of growth factors for bone augmentation to enable dental implant placement: A systematic review",
abstract = "This systematic review assessed the potential benefits of growth factors for bone augmentation prior to the placement of dental implants in human. A systematic online review of the Medline database, using the PubMed search machine was performed between 1966 and November 2008 by entering the MeSH terms. The primary outcome of the included studies was bone regeneration of localized alveolar ridge defects. The initial search identified 119 papers from the electronic database. This review produced seven eligible papers that reported on bone augmentation with recombinant human Bone Morphogenetic Protein-2 (rhBMP-2), recombinant human Platelet-Derived Growth Factor (rhPDGF) and Plasma-Rich Growth Factor (PRGF). The rhBMP-2 affected local bone augmentation with increasing volume for higher doses. Both rhPDGF and PRGF showed a positive effect in favor of the growth factor. Differing levels and quantity of evidence were noted to be available for the growth factors evaluated, revealing that rhBMP-2, rhPDGF, and PRGF may stimulate local bone augmentation to various conditions. Especially the potential of rhBMP-2 is supportive. However, the confined number of investigators using these techniques and the low number of patient treatments reported in the literature, the generalizability of this approach is limited at this time.",
keywords = "Bone augmentation, Clinical trial, Dental implant, Growth factors, Systematic review",
author = "Kengo Shimono and Masamitsu Oshima and Hikaru Arakawa and Aya Ono and Kumiko Nawachi and Takuo Kuboki",
year = "2010",
month = "2",
doi = "10.1016/j.jdsr.2009.10.004",
language = "English",
volume = "46",
pages = "43--53",
journal = "Japanese Dental Science Review",
issn = "1882-7616",
publisher = "Elsevier BV",
number = "1",

}

TY - JOUR

T1 - The effect of growth factors for bone augmentation to enable dental implant placement

T2 - A systematic review

AU - Shimono, Kengo

AU - Oshima, Masamitsu

AU - Arakawa, Hikaru

AU - Ono, Aya

AU - Nawachi, Kumiko

AU - Kuboki, Takuo

PY - 2010/2

Y1 - 2010/2

N2 - This systematic review assessed the potential benefits of growth factors for bone augmentation prior to the placement of dental implants in human. A systematic online review of the Medline database, using the PubMed search machine was performed between 1966 and November 2008 by entering the MeSH terms. The primary outcome of the included studies was bone regeneration of localized alveolar ridge defects. The initial search identified 119 papers from the electronic database. This review produced seven eligible papers that reported on bone augmentation with recombinant human Bone Morphogenetic Protein-2 (rhBMP-2), recombinant human Platelet-Derived Growth Factor (rhPDGF) and Plasma-Rich Growth Factor (PRGF). The rhBMP-2 affected local bone augmentation with increasing volume for higher doses. Both rhPDGF and PRGF showed a positive effect in favor of the growth factor. Differing levels and quantity of evidence were noted to be available for the growth factors evaluated, revealing that rhBMP-2, rhPDGF, and PRGF may stimulate local bone augmentation to various conditions. Especially the potential of rhBMP-2 is supportive. However, the confined number of investigators using these techniques and the low number of patient treatments reported in the literature, the generalizability of this approach is limited at this time.

AB - This systematic review assessed the potential benefits of growth factors for bone augmentation prior to the placement of dental implants in human. A systematic online review of the Medline database, using the PubMed search machine was performed between 1966 and November 2008 by entering the MeSH terms. The primary outcome of the included studies was bone regeneration of localized alveolar ridge defects. The initial search identified 119 papers from the electronic database. This review produced seven eligible papers that reported on bone augmentation with recombinant human Bone Morphogenetic Protein-2 (rhBMP-2), recombinant human Platelet-Derived Growth Factor (rhPDGF) and Plasma-Rich Growth Factor (PRGF). The rhBMP-2 affected local bone augmentation with increasing volume for higher doses. Both rhPDGF and PRGF showed a positive effect in favor of the growth factor. Differing levels and quantity of evidence were noted to be available for the growth factors evaluated, revealing that rhBMP-2, rhPDGF, and PRGF may stimulate local bone augmentation to various conditions. Especially the potential of rhBMP-2 is supportive. However, the confined number of investigators using these techniques and the low number of patient treatments reported in the literature, the generalizability of this approach is limited at this time.

KW - Bone augmentation

KW - Clinical trial

KW - Dental implant

KW - Growth factors

KW - Systematic review

UR - http://www.scopus.com/inward/record.url?scp=74449084477&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=74449084477&partnerID=8YFLogxK

U2 - 10.1016/j.jdsr.2009.10.004

DO - 10.1016/j.jdsr.2009.10.004

M3 - Article

VL - 46

SP - 43

EP - 53

JO - Japanese Dental Science Review

JF - Japanese Dental Science Review

SN - 1882-7616

IS - 1

ER -