The effect of ethyl loflazepate on refractory epilepsy

N. Murakami, T. Asano, T. Ogino, Katsuhiro Kobayashi, Y. Ohtsuka, E. Oka

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

In order to evaluate the effect of ethyl loflazepate (LOF), we performed a clinical and electroencephalographic study on patients with childhood refractory epilepsy. We investigated the effect of LOF add-on therapy on clinical seizures and EEGs as well as side effects in 41 patients, ranging in age from 3 months to 23 years 6 months. The patients were treated with LOF for at least three months. LOF had marked or moderate effects in 25 patients (60.9%). However, in 11 patients, these effects were transient and disappeared within the first three months. LOF was more effective for symptomatic generalized epilepsy than other types of epilepsy. LOF was most effective for brief tonic seizures or tonic seizures. Epileptic discharges were suppressed or decreased in five of 14 patients who responded well to LOF. The maximum dose was well correlated with blood level (R=0.691). Twenty patients (49%) showed mild side effects, such as sleepiness and hypersalivation.

Original languageEnglish
Pages (from-to)133-139
Number of pages7
JournalJournal of the Japan Epilepsy Society
Volume18
Issue number2
Publication statusPublished - 2000

Fingerprint

Epilepsy
Seizures
Sialorrhea
Generalized Epilepsy
ethyl loflazepate
Electroencephalography

Keywords

  • Benzodiazepine
  • Childhood epilepsy
  • Ethyl loflazepate
  • Refractory epilepsy
  • Treatment

ASJC Scopus subject areas

  • Clinical Neurology

Cite this

Murakami, N., Asano, T., Ogino, T., Kobayashi, K., Ohtsuka, Y., & Oka, E. (2000). The effect of ethyl loflazepate on refractory epilepsy. Journal of the Japan Epilepsy Society, 18(2), 133-139.

The effect of ethyl loflazepate on refractory epilepsy. / Murakami, N.; Asano, T.; Ogino, T.; Kobayashi, Katsuhiro; Ohtsuka, Y.; Oka, E.

In: Journal of the Japan Epilepsy Society, Vol. 18, No. 2, 2000, p. 133-139.

Research output: Contribution to journalArticle

Murakami, N, Asano, T, Ogino, T, Kobayashi, K, Ohtsuka, Y & Oka, E 2000, 'The effect of ethyl loflazepate on refractory epilepsy', Journal of the Japan Epilepsy Society, vol. 18, no. 2, pp. 133-139.
Murakami N, Asano T, Ogino T, Kobayashi K, Ohtsuka Y, Oka E. The effect of ethyl loflazepate on refractory epilepsy. Journal of the Japan Epilepsy Society. 2000;18(2):133-139.
Murakami, N. ; Asano, T. ; Ogino, T. ; Kobayashi, Katsuhiro ; Ohtsuka, Y. ; Oka, E. / The effect of ethyl loflazepate on refractory epilepsy. In: Journal of the Japan Epilepsy Society. 2000 ; Vol. 18, No. 2. pp. 133-139.
@article{f54127f7a5c94296ab879b6e266d857d,
title = "The effect of ethyl loflazepate on refractory epilepsy",
abstract = "In order to evaluate the effect of ethyl loflazepate (LOF), we performed a clinical and electroencephalographic study on patients with childhood refractory epilepsy. We investigated the effect of LOF add-on therapy on clinical seizures and EEGs as well as side effects in 41 patients, ranging in age from 3 months to 23 years 6 months. The patients were treated with LOF for at least three months. LOF had marked or moderate effects in 25 patients (60.9{\%}). However, in 11 patients, these effects were transient and disappeared within the first three months. LOF was more effective for symptomatic generalized epilepsy than other types of epilepsy. LOF was most effective for brief tonic seizures or tonic seizures. Epileptic discharges were suppressed or decreased in five of 14 patients who responded well to LOF. The maximum dose was well correlated with blood level (R=0.691). Twenty patients (49{\%}) showed mild side effects, such as sleepiness and hypersalivation.",
keywords = "Benzodiazepine, Childhood epilepsy, Ethyl loflazepate, Refractory epilepsy, Treatment",
author = "N. Murakami and T. Asano and T. Ogino and Katsuhiro Kobayashi and Y. Ohtsuka and E. Oka",
year = "2000",
language = "English",
volume = "18",
pages = "133--139",
journal = "Journal of the Japan Epilepsy Society",
issn = "0912-0890",
publisher = "Japan Epilepsy Society",
number = "2",

}

TY - JOUR

T1 - The effect of ethyl loflazepate on refractory epilepsy

AU - Murakami, N.

AU - Asano, T.

AU - Ogino, T.

AU - Kobayashi, Katsuhiro

AU - Ohtsuka, Y.

AU - Oka, E.

PY - 2000

Y1 - 2000

N2 - In order to evaluate the effect of ethyl loflazepate (LOF), we performed a clinical and electroencephalographic study on patients with childhood refractory epilepsy. We investigated the effect of LOF add-on therapy on clinical seizures and EEGs as well as side effects in 41 patients, ranging in age from 3 months to 23 years 6 months. The patients were treated with LOF for at least three months. LOF had marked or moderate effects in 25 patients (60.9%). However, in 11 patients, these effects were transient and disappeared within the first three months. LOF was more effective for symptomatic generalized epilepsy than other types of epilepsy. LOF was most effective for brief tonic seizures or tonic seizures. Epileptic discharges were suppressed or decreased in five of 14 patients who responded well to LOF. The maximum dose was well correlated with blood level (R=0.691). Twenty patients (49%) showed mild side effects, such as sleepiness and hypersalivation.

AB - In order to evaluate the effect of ethyl loflazepate (LOF), we performed a clinical and electroencephalographic study on patients with childhood refractory epilepsy. We investigated the effect of LOF add-on therapy on clinical seizures and EEGs as well as side effects in 41 patients, ranging in age from 3 months to 23 years 6 months. The patients were treated with LOF for at least three months. LOF had marked or moderate effects in 25 patients (60.9%). However, in 11 patients, these effects were transient and disappeared within the first three months. LOF was more effective for symptomatic generalized epilepsy than other types of epilepsy. LOF was most effective for brief tonic seizures or tonic seizures. Epileptic discharges were suppressed or decreased in five of 14 patients who responded well to LOF. The maximum dose was well correlated with blood level (R=0.691). Twenty patients (49%) showed mild side effects, such as sleepiness and hypersalivation.

KW - Benzodiazepine

KW - Childhood epilepsy

KW - Ethyl loflazepate

KW - Refractory epilepsy

KW - Treatment

UR - http://www.scopus.com/inward/record.url?scp=0033928472&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0033928472&partnerID=8YFLogxK

M3 - Article

AN - SCOPUS:0033928472

VL - 18

SP - 133

EP - 139

JO - Journal of the Japan Epilepsy Society

JF - Journal of the Japan Epilepsy Society

SN - 0912-0890

IS - 2

ER -