The effect of endoscopical intratumoral injection of OK-432 in gastric carcinoma

A. Gochi, S. Fuchimoto, K. Orita, E. Konaga, S. Okamura, T. Mannami, K. Sato

Research output: Contribution to journalArticle

Abstract

Many BRMs (biological response modifiers) have been used for post-operative immunochemotherapy. And their usefulness were also reported. Nevertheless it is still unknown that which route, how much doses and which timing are the most effective to administer these drugs. We used BRMs intratumorally and preoperatively. To reconfirm the efficacy of intratumoral injection therapy randomized study was performed in gastric carcinoma. Three hundred and ninety-five cases were entered, 199 cases in group A which were treated preoperatively with OK-432 intratumorally and 196 cases in group B which were control, respectively. In the cases which had marked infiltration of lymphoid cells in tumor sites, the two year survival rate of group A was significantly better than that of group B (p less than 0.05). On the study of recurrent forms, the distal lymph node metastasis was markedly decreased in group A. The ratio of metastasis to the distal lymph nodes in group A was 5-10% lesser than that in group B on the each depth of tumor invasion. The ratio of lymph nodes metastasis was almost similar in the each group, but the number of metastatic lymph nodes was significantly reduced in high grade tumor infiltrated cases in group A (p less than 0.005). These results suggest that preoperative endoscopically intratumoral administration of OK-432 suppresses the lymph node metastasis and improves the postoperative survival rate.

Original languageEnglish
Pages (from-to)1439-1442
Number of pages4
JournalNippon Geka Gakkai zasshi
Volume90
Issue number9
Publication statusPublished - Sep 1989

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Picibanil
Stomach
Lymph Nodes
Carcinoma
Injections
Neoplasm Metastasis
Immunologic Factors
Neoplasms
Lymphocytes
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Gochi, A., Fuchimoto, S., Orita, K., Konaga, E., Okamura, S., Mannami, T., & Sato, K. (1989). The effect of endoscopical intratumoral injection of OK-432 in gastric carcinoma. Nippon Geka Gakkai zasshi, 90(9), 1439-1442.

The effect of endoscopical intratumoral injection of OK-432 in gastric carcinoma. / Gochi, A.; Fuchimoto, S.; Orita, K.; Konaga, E.; Okamura, S.; Mannami, T.; Sato, K.

In: Nippon Geka Gakkai zasshi, Vol. 90, No. 9, 09.1989, p. 1439-1442.

Research output: Contribution to journalArticle

Gochi, A, Fuchimoto, S, Orita, K, Konaga, E, Okamura, S, Mannami, T & Sato, K 1989, 'The effect of endoscopical intratumoral injection of OK-432 in gastric carcinoma', Nippon Geka Gakkai zasshi, vol. 90, no. 9, pp. 1439-1442.
Gochi A, Fuchimoto S, Orita K, Konaga E, Okamura S, Mannami T et al. The effect of endoscopical intratumoral injection of OK-432 in gastric carcinoma. Nippon Geka Gakkai zasshi. 1989 Sep;90(9):1439-1442.
Gochi, A. ; Fuchimoto, S. ; Orita, K. ; Konaga, E. ; Okamura, S. ; Mannami, T. ; Sato, K. / The effect of endoscopical intratumoral injection of OK-432 in gastric carcinoma. In: Nippon Geka Gakkai zasshi. 1989 ; Vol. 90, No. 9. pp. 1439-1442.
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