The effect of diabetes mellitus on the expression of Argyrophilic nucleolar organizer regions (AgNORs) in mucosal epithelium under experimental denture bases in rats

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Abstract

Background: Expression of argyrophilic nucleolar organizer regions (AgNOR) was counted on mucosal epithelium to detect whether the AgNOR count (the number of AgNOR per nucleus) is, for 20 weeks, affected by streptozotocin-induced diabetes mellitus. Methods: Diabetic rats were applied non-denture wearing, nonpressure contact, continuous pressure (0.5, 1.5 or 3.4 kPa) and intermittent pressure (10.5, 33.0 or 81.7 kPa), respectively. Results: In the non-denture wearing or the non-pressure contact group, AgNOR count was almost constant (ranging 1.86-1.92) without significant difference. Under continuous pressure, AgNOR count significantly decreased at earlier stage and finally recovered to the non-pressure contact group. A similar effect of continuous pressure appeared to manifest itself in intermittent pressure, but to a greater degree. Consequently, AgNOR count under intermittent pressure showed no recovery at 20-week stage. Conclusion: Diabetes mellitus exerted, by itself, no influence on the cellular proliferative activity under continuous pressure, whereas the activity deteriorated under intermittent pressure.

Original languageEnglish
Pages (from-to)171-175
Number of pages5
JournalJournal of Oral Pathology and Medicine
Volume32
Issue number3
DOIs
Publication statusPublished - Mar 2003

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Denture Bases
Nucleolus Organizer Region
Diabetes Mellitus
Epithelium
Pressure
Experimental Diabetes Mellitus

Keywords

  • AgNOR
  • Cellular proliferative activity
  • Denture base
  • Diabetes mellitus

ASJC Scopus subject areas

  • Cancer Research
  • Pathology and Forensic Medicine
  • Dentistry(all)

Cite this

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title = "The effect of diabetes mellitus on the expression of Argyrophilic nucleolar organizer regions (AgNORs) in mucosal epithelium under experimental denture bases in rats",
abstract = "Background: Expression of argyrophilic nucleolar organizer regions (AgNOR) was counted on mucosal epithelium to detect whether the AgNOR count (the number of AgNOR per nucleus) is, for 20 weeks, affected by streptozotocin-induced diabetes mellitus. Methods: Diabetic rats were applied non-denture wearing, nonpressure contact, continuous pressure (0.5, 1.5 or 3.4 kPa) and intermittent pressure (10.5, 33.0 or 81.7 kPa), respectively. Results: In the non-denture wearing or the non-pressure contact group, AgNOR count was almost constant (ranging 1.86-1.92) without significant difference. Under continuous pressure, AgNOR count significantly decreased at earlier stage and finally recovered to the non-pressure contact group. A similar effect of continuous pressure appeared to manifest itself in intermittent pressure, but to a greater degree. Consequently, AgNOR count under intermittent pressure showed no recovery at 20-week stage. Conclusion: Diabetes mellitus exerted, by itself, no influence on the cellular proliferative activity under continuous pressure, whereas the activity deteriorated under intermittent pressure.",
keywords = "AgNOR, Cellular proliferative activity, Denture base, Diabetes mellitus",
author = "Yukinori Maruo and Takashi Sato and Tetsuya Hara and Shingo Mori and Hajime Shirai and Shougo Minagi",
year = "2003",
month = "3",
doi = "10.1034/j.1600-0714.2003.00066.x",
language = "English",
volume = "32",
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T1 - The effect of diabetes mellitus on the expression of Argyrophilic nucleolar organizer regions (AgNORs) in mucosal epithelium under experimental denture bases in rats

AU - Maruo, Yukinori

AU - Sato, Takashi

AU - Hara, Tetsuya

AU - Mori, Shingo

AU - Shirai, Hajime

AU - Minagi, Shougo

PY - 2003/3

Y1 - 2003/3

N2 - Background: Expression of argyrophilic nucleolar organizer regions (AgNOR) was counted on mucosal epithelium to detect whether the AgNOR count (the number of AgNOR per nucleus) is, for 20 weeks, affected by streptozotocin-induced diabetes mellitus. Methods: Diabetic rats were applied non-denture wearing, nonpressure contact, continuous pressure (0.5, 1.5 or 3.4 kPa) and intermittent pressure (10.5, 33.0 or 81.7 kPa), respectively. Results: In the non-denture wearing or the non-pressure contact group, AgNOR count was almost constant (ranging 1.86-1.92) without significant difference. Under continuous pressure, AgNOR count significantly decreased at earlier stage and finally recovered to the non-pressure contact group. A similar effect of continuous pressure appeared to manifest itself in intermittent pressure, but to a greater degree. Consequently, AgNOR count under intermittent pressure showed no recovery at 20-week stage. Conclusion: Diabetes mellitus exerted, by itself, no influence on the cellular proliferative activity under continuous pressure, whereas the activity deteriorated under intermittent pressure.

AB - Background: Expression of argyrophilic nucleolar organizer regions (AgNOR) was counted on mucosal epithelium to detect whether the AgNOR count (the number of AgNOR per nucleus) is, for 20 weeks, affected by streptozotocin-induced diabetes mellitus. Methods: Diabetic rats were applied non-denture wearing, nonpressure contact, continuous pressure (0.5, 1.5 or 3.4 kPa) and intermittent pressure (10.5, 33.0 or 81.7 kPa), respectively. Results: In the non-denture wearing or the non-pressure contact group, AgNOR count was almost constant (ranging 1.86-1.92) without significant difference. Under continuous pressure, AgNOR count significantly decreased at earlier stage and finally recovered to the non-pressure contact group. A similar effect of continuous pressure appeared to manifest itself in intermittent pressure, but to a greater degree. Consequently, AgNOR count under intermittent pressure showed no recovery at 20-week stage. Conclusion: Diabetes mellitus exerted, by itself, no influence on the cellular proliferative activity under continuous pressure, whereas the activity deteriorated under intermittent pressure.

KW - AgNOR

KW - Cellular proliferative activity

KW - Denture base

KW - Diabetes mellitus

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