The effect of ascorbate on minor recurrent aphthous stomatitis

K. Yasui, T. Kurata, Masato Yashiro, Mitsuru Tsuge, Shin-ichi Ohtsuki, T. Morishima

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Aim: Minor recurrent aphthous stomatitis (MRAS) is a common, painful and inflammatory ailment of the oral cavity with juvenile onset and unknown aetiology. The purpose of this study was to evaluate the potential of ascorbate (vitamin C) to reduce the frequency of MRAS and severity of pain. Patients and methods: Sixteen MRAS patients (9 boys and 7 girls: mean age, 12.0 ± 2.4 years old) were assigned to take an oral dosage of 2000 mg/m2/day ascorbate. Subjects: Their baseline frequency of outbreaks and the level of pains were compared during the treatment; in addition, a crossover clinical trial was performed. Polymorphonuclear leucocytes play a role in the pathogenesis, and then superoxide anion production was evaluated in prior to ascorbate treatment. Results: The data indicated a statistically significant 50% reduction in oral ulcer outbreaks and a decline of pain level. Neutrophils were primed for superoxide anion production in the patients with MRAS. Conclusion: Ascorbate may modulate the generation of reactive oxygen species and augment neutrophil apoptosis, which could prevent neutrophil-mediated inflammation. Ascorbate seems to be effective, but the findings of our study were preliminary and it should be re-evaluated with a larger randomized controlled clinical trials.

Original languageEnglish
Pages (from-to)442-445
Number of pages4
JournalActa Paediatrica, International Journal of Paediatrics
Volume99
Issue number3
DOIs
Publication statusPublished - Mar 2010

Fingerprint

Neutrophils
Pain
Superoxides
Disease Outbreaks
Oral Ulcer
Cross-Over Studies
Ascorbic Acid
Mouth
Reactive Oxygen Species
Randomized Controlled Trials
Clinical Trials
Apoptosis
Inflammation
Sutton disease 2
Therapeutics

Keywords

  • Apoptosis
  • Neutrophil
  • Oxidative stress
  • Redox

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Cite this

The effect of ascorbate on minor recurrent aphthous stomatitis. / Yasui, K.; Kurata, T.; Yashiro, Masato; Tsuge, Mitsuru; Ohtsuki, Shin-ichi; Morishima, T.

In: Acta Paediatrica, International Journal of Paediatrics, Vol. 99, No. 3, 03.2010, p. 442-445.

Research output: Contribution to journalArticle

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