The effect of a new immunosuppressive agent, FK-506, on xenogeneic neural transplantation in rodents

Kyoji Sakai, Isao Date, Yusuke Yoshimoto, Tadashi Arisawa, Hiroyuki Nakashima, Tomohisa Furuta, Shoji Asari, Takashi Ohmoto

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Abstract

This study examines the effect of a novel immunosuppressive agent FK-506 (FK) on the survivability of embryonic (E14) rat ventral mesencephalic tissue after intracerebral grafting to the lateral ventricle of adult mice. The recipient mice were given FK in doses of 10 mg/kg or 1 mg/kg for 2 weeks postgrafting, at which time they were sacrificed and histologically processed except for one group of animals on the high dose (10 mg/kg). In this group most animals died from side effects of the drug during the following days. Only the mice receiving the high dose of FK displayed healthy grafts without signs of rejection.

Original languageEnglish
Pages (from-to)167-170
Number of pages4
JournalBrain Research
Volume565
Issue number1
DOIs
Publication statusPublished - Nov 22 1991

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Keywords

  • FK-506
  • Immunosuppression
  • Neural transplantation
  • Xenograft

ASJC Scopus subject areas

  • Developmental Biology
  • Molecular Biology
  • Clinical Neurology
  • Neuroscience(all)

Cite this

Sakai, K., Date, I., Yoshimoto, Y., Arisawa, T., Nakashima, H., Furuta, T., Asari, S., & Ohmoto, T. (1991). The effect of a new immunosuppressive agent, FK-506, on xenogeneic neural transplantation in rodents. Brain Research, 565(1), 167-170. https://doi.org/10.1016/0006-8993(91)91750-U