The effect of a new immunosuppressive agent, FK-506, on xenogeneic neural transplantation in rodents

Kyoji Sakai; Isao Date; Yusuke Yoshimoto; Tadashi Arisawa; Hiroyuki Nakashima; Tomohisa Furuta; Shoji Asari; Takashi Ohmoto

doi:10.1016/0006-8993(91)91750-U

The effect of a new immunosuppressive agent, FK-506, on xenogeneic neural transplantation in rodents

Kyoji Sakai, Isao Date, Yusuke Yoshimoto, Tadashi Arisawa, Hiroyuki Nakashima, Tomohisa Furuta, Shoji Asari, Takashi Ohmoto

Research output: Contribution to journal › Article › peer-review

45 Citations (Scopus)

Abstract

This study examines the effect of a novel immunosuppressive agent FK-506 (FK) on the survivability of embryonic (E14) rat ventral mesencephalic tissue after intracerebral grafting to the lateral ventricle of adult mice. The recipient mice were given FK in doses of 10 mg/kg or 1 mg/kg for 2 weeks postgrafting, at which time they were sacrificed and histologically processed except for one group of animals on the high dose (10 mg/kg). In this group most animals died from side effects of the drug during the following days. Only the mice receiving the high dose of FK displayed healthy grafts without signs of rejection.

Original language	English
Pages (from-to)	167-170
Number of pages	4
Journal	Brain Research
Volume	565
Issue number	1
DOIs	https://doi.org/10.1016/0006-8993(91)91750-U
Publication status	Published - Nov 22 1991

Keywords

FK-506
Immunosuppression
Neural transplantation
Xenograft

ASJC Scopus subject areas

Neuroscience(all)
Molecular Biology
Clinical Neurology
Developmental Biology

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10.1016/0006-8993(91)91750-U

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abstract = "This study examines the effect of a novel immunosuppressive agent FK-506 (FK) on the survivability of embryonic (E14) rat ventral mesencephalic tissue after intracerebral grafting to the lateral ventricle of adult mice. The recipient mice were given FK in doses of 10 mg/kg or 1 mg/kg for 2 weeks postgrafting, at which time they were sacrificed and histologically processed except for one group of animals on the high dose (10 mg/kg). In this group most animals died from side effects of the drug during the following days. Only the mice receiving the high dose of FK displayed healthy grafts without signs of rejection.",

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AU - Nakashima, Hiroyuki

AU - Furuta, Tomohisa

AU - Asari, Shoji

AU - Ohmoto, Takashi

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The effect of a new immunosuppressive agent, FK-506, on xenogeneic neural transplantation in rodents

Abstract

Keywords

ASJC Scopus subject areas

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