TY - JOUR
T1 - The disruption of spatial cognition and changes in brain amino acid, monoamine and acetylcholine in rats with transient cerebral ischemia
AU - Iwasaki, Katsunori
AU - Kitamura, Yoshihisa
AU - Ohgami, Yusuke
AU - Mishima, Kenichi
AU - Fujiwara, Michihiro
N1 - Funding Information:
This study was supported by a Grant-in-Aid for Scientific Research from the Japanese Ministry of Education, Science and Culture. The authors are grateful to Dr. B. Quinn for his comments on the manuscript.
Copyright:
Copyright 2017 Elsevier B.V., All rights reserved.
PY - 1996/2/19
Y1 - 1996/2/19
N2 - We investigated the disruption of spatial cognition due to transient forebrain ischemia using an 8-arm radial arm maze task in rats. Five or 10 min of ischemia did not affect the task acquisition. When rats established spatial cognition by daily training of the task, 10 min of ischemia significantly decreased the number of correct choices and increased the errors in the task when performed 24 h after reperfusion. These changes, however, returned to the normal level after about 4 days of daily training. Glutamic acid (Glu) and acetylcholine (ACh) release from the dorsal hippocampus (DH) was observed to transiently increase during ischemia. However, neither the content of noradrenaline (NA) nor the release of NA in the DH changed during ischemia. The NA and ACh release from the DH, however, gradually decreased during reperfusion, and the decrease became significant at 24 h after reperfusion. The NA content of the frontal cortex (FC) and the DH increased 7 days after reperfusion. These results suggest that the disruption of spatial cognition induced by 10 min of ischemia may be attributed to a greater degree to the dysfunction of the hippocampal ACh and NA, and cortical NA systems, rather than to the development of neuronal cell death in these areas.
AB - We investigated the disruption of spatial cognition due to transient forebrain ischemia using an 8-arm radial arm maze task in rats. Five or 10 min of ischemia did not affect the task acquisition. When rats established spatial cognition by daily training of the task, 10 min of ischemia significantly decreased the number of correct choices and increased the errors in the task when performed 24 h after reperfusion. These changes, however, returned to the normal level after about 4 days of daily training. Glutamic acid (Glu) and acetylcholine (ACh) release from the dorsal hippocampus (DH) was observed to transiently increase during ischemia. However, neither the content of noradrenaline (NA) nor the release of NA in the DH changed during ischemia. The NA and ACh release from the DH, however, gradually decreased during reperfusion, and the decrease became significant at 24 h after reperfusion. The NA content of the frontal cortex (FC) and the DH increased 7 days after reperfusion. These results suggest that the disruption of spatial cognition induced by 10 min of ischemia may be attributed to a greater degree to the dysfunction of the hippocampal ACh and NA, and cortical NA systems, rather than to the development of neuronal cell death in these areas.
KW - 8-Arm radial maze task
KW - Acetylcholine
KW - Cerebral ischemia
KW - Glutamate
KW - Microdialysis
KW - Noradrenaline
KW - Spatial cognition
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U2 - 10.1016/0006-8993(95)01235-4
DO - 10.1016/0006-8993(95)01235-4
M3 - Article
C2 - 8833752
AN - SCOPUS:0030029959
VL - 709
SP - 163
EP - 172
JO - Molecular Brain Research
JF - Molecular Brain Research
SN - 0006-8993
IS - 2
ER -