The discordance between primary breast cancer lesions and pulmonary metastatic lesions in expression of aldehyde dehydrogenase 1-positive cancer cells

Tomohiro Nogami; Tadahiko Shien; Takehiro Tanaka; Hiroyoshi Doihara; Naruto Taira; Daisuke Takabatake; Rieko Nishimura; Keiko Nishiyama; Taeko Mizoo; Shozo Ohsumi

doi:10.1007/s12282-013-0445-7

The discordance between primary breast cancer lesions and pulmonary metastatic lesions in expression of aldehyde dehydrogenase 1-positive cancer cells

Tomohiro Nogami, Tadahiko Shien, Takehiro Tanaka, Hiroyoshi Doihara, Naruto Taira, Daisuke Takabatake, Rieko Nishimura, Keiko Nishiyama, Taeko Mizoo, Shozo Ohsumi

University Hospital

Research output: Contribution to journal › Article › peer-review

8 Citations (Scopus)

Abstract

BACKGROUND: We evaluated the expression of aldehyde dehydrogenase 1 (ALDH1) between primary breast lesions and pulmonary metastatic (PM) lesions in breast cancer patients.

METHODS: We retrospectively analyzed the clinicopathological features and the expression statuses of ER, PR, HER2, Ki-67 and ALDH-1 in both primary and metastatic breast cancer lesions and evaluated the discordance rates in the expressions of these markers between the primary and metastatic lesions, and also the prognostic value of these factors.

RESULTS: None of the PM patients had metastases at any other sites, and all had undergone curative breast cancer surgery. The pulmonary operation was partial resection in 15 (88 %) patients and lobectomy in 2 (12 %) patients. The median overall survival (OS) after resection of the PNs (OS) was 48 months. The discordance rates in the expressions of ER, PR, HER2, Ki67 and ALDH-1 between the primary and metastatic lesions were 0, 29, 21, 43 and 50 %, respectively.

CONCLUSION: There was significant discordance in the biomarkers between the primary tumors and the metastatic lesions.

Original language	English
Pages (from-to)	698-702
Number of pages	5
Journal	Breast Cancer
Volume	21
Issue number	6
DOIs	https://doi.org/10.1007/s12282-013-0445-7
Publication status	Published - Nov 1 2014

ASJC Scopus subject areas

Medicine(all)

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10.1007/s12282-013-0445-7

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title = "The discordance between primary breast cancer lesions and pulmonary metastatic lesions in expression of aldehyde dehydrogenase 1-positive cancer cells",

abstract = "BACKGROUND: We evaluated the expression of aldehyde dehydrogenase 1 (ALDH1) between primary breast lesions and pulmonary metastatic (PM) lesions in breast cancer patients.METHODS: We retrospectively analyzed the clinicopathological features and the expression statuses of ER, PR, HER2, Ki-67 and ALDH-1 in both primary and metastatic breast cancer lesions and evaluated the discordance rates in the expressions of these markers between the primary and metastatic lesions, and also the prognostic value of these factors.RESULTS: None of the PM patients had metastases at any other sites, and all had undergone curative breast cancer surgery. The pulmonary operation was partial resection in 15 (88 %) patients and lobectomy in 2 (12 %) patients. The median overall survival (OS) after resection of the PNs (OS) was 48 months. The discordance rates in the expressions of ER, PR, HER2, Ki67 and ALDH-1 between the primary and metastatic lesions were 0, 29, 21, 43 and 50 %, respectively.CONCLUSION: There was significant discordance in the biomarkers between the primary tumors and the metastatic lesions.",

author = "Tomohiro Nogami and Tadahiko Shien and Takehiro Tanaka and Hiroyoshi Doihara and Naruto Taira and Daisuke Takabatake and Rieko Nishimura and Keiko Nishiyama and Taeko Mizoo and Shozo Ohsumi",

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doi = "10.1007/s12282-013-0445-7",

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T1 - The discordance between primary breast cancer lesions and pulmonary metastatic lesions in expression of aldehyde dehydrogenase 1-positive cancer cells

AU - Nogami, Tomohiro

AU - Shien, Tadahiko

AU - Tanaka, Takehiro

AU - Doihara, Hiroyoshi

AU - Taira, Naruto

AU - Takabatake, Daisuke

AU - Nishimura, Rieko

AU - Nishiyama, Keiko

AU - Mizoo, Taeko

AU - Ohsumi, Shozo

PY - 2014/11/1

Y1 - 2014/11/1

N2 - BACKGROUND: We evaluated the expression of aldehyde dehydrogenase 1 (ALDH1) between primary breast lesions and pulmonary metastatic (PM) lesions in breast cancer patients.METHODS: We retrospectively analyzed the clinicopathological features and the expression statuses of ER, PR, HER2, Ki-67 and ALDH-1 in both primary and metastatic breast cancer lesions and evaluated the discordance rates in the expressions of these markers between the primary and metastatic lesions, and also the prognostic value of these factors.RESULTS: None of the PM patients had metastases at any other sites, and all had undergone curative breast cancer surgery. The pulmonary operation was partial resection in 15 (88 %) patients and lobectomy in 2 (12 %) patients. The median overall survival (OS) after resection of the PNs (OS) was 48 months. The discordance rates in the expressions of ER, PR, HER2, Ki67 and ALDH-1 between the primary and metastatic lesions were 0, 29, 21, 43 and 50 %, respectively.CONCLUSION: There was significant discordance in the biomarkers between the primary tumors and the metastatic lesions.

AB - BACKGROUND: We evaluated the expression of aldehyde dehydrogenase 1 (ALDH1) between primary breast lesions and pulmonary metastatic (PM) lesions in breast cancer patients.METHODS: We retrospectively analyzed the clinicopathological features and the expression statuses of ER, PR, HER2, Ki-67 and ALDH-1 in both primary and metastatic breast cancer lesions and evaluated the discordance rates in the expressions of these markers between the primary and metastatic lesions, and also the prognostic value of these factors.RESULTS: None of the PM patients had metastases at any other sites, and all had undergone curative breast cancer surgery. The pulmonary operation was partial resection in 15 (88 %) patients and lobectomy in 2 (12 %) patients. The median overall survival (OS) after resection of the PNs (OS) was 48 months. The discordance rates in the expressions of ER, PR, HER2, Ki67 and ALDH-1 between the primary and metastatic lesions were 0, 29, 21, 43 and 50 %, respectively.CONCLUSION: There was significant discordance in the biomarkers between the primary tumors and the metastatic lesions.

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JO - Breast Cancer

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The discordance between primary breast cancer lesions and pulmonary metastatic lesions in expression of aldehyde dehydrogenase 1-positive cancer cells

Abstract

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