TY - JOUR
T1 - The difference in temporal distribution of c-Fos immunoreactive neurons between the medullary dorsal horn and the trigeminal subnucleus oralis in the rat following experimental tooth movement
AU - Fujiyoshi, Yoshiaki
AU - Yamashiro, Takashi
AU - Deguchi, Toru
AU - Sugimoto, Tomosada
AU - Takano-Yamamoto, Teruko
N1 - Funding Information:
This study was supported in part by Grants-in-Aid for Scientific Research from the Ministry of Education, Science and Culture of Japan (10470446, 10557197, 11771318).
PY - 2000/4/14
Y1 - 2000/4/14
N2 - The difference in temporal distribution of c-Fos-immunoreactivity (Fos-IR) was assessed in the medullary dorsal horn (MDH) and in the dorsomedial part of the trigeminal subnucleus oralis (Vodm) following experimental tooth movement of the rat maxillary molars. The number of MDH c-Fos-immunoreactive neurons increased bilaterally at 2 h and decreased markedly by 12 h, and then increased again with a small peak at 48 h. In contrast, Vodm c-Fos expression was not up-regulated until 12 h, but increased in number after 24 h, which increase lasted until 72 h. These findings indicate that experimental tooth movement induced nociceptive c-Fos response in a biphasic manner. Furthermore, the later response appeared after 24 h, and lasted for a few days, mainly manifested in the Vodm during experimental tooth movement. Copyright (C) 2000 Elsevier Science Ireland Ltd.
AB - The difference in temporal distribution of c-Fos-immunoreactivity (Fos-IR) was assessed in the medullary dorsal horn (MDH) and in the dorsomedial part of the trigeminal subnucleus oralis (Vodm) following experimental tooth movement of the rat maxillary molars. The number of MDH c-Fos-immunoreactive neurons increased bilaterally at 2 h and decreased markedly by 12 h, and then increased again with a small peak at 48 h. In contrast, Vodm c-Fos expression was not up-regulated until 12 h, but increased in number after 24 h, which increase lasted until 72 h. These findings indicate that experimental tooth movement induced nociceptive c-Fos response in a biphasic manner. Furthermore, the later response appeared after 24 h, and lasted for a few days, mainly manifested in the Vodm during experimental tooth movement. Copyright (C) 2000 Elsevier Science Ireland Ltd.
KW - Medullary dorsal horn
KW - Nociception
KW - Subnucleus oralis
KW - Tooth movement
KW - Two responses
KW - c-Fos
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U2 - 10.1016/S0304-3940(00)00962-9
DO - 10.1016/S0304-3940(00)00962-9
M3 - Article
C2 - 10754223
AN - SCOPUS:0034646924
VL - 283
SP - 205
EP - 208
JO - Neuroscience Letters
JF - Neuroscience Letters
SN - 0304-3940
IS - 3
ER -