The difference in temporal distribution of c-Fos immunoreactive neurons between the medullary dorsal horn and the trigeminal subnucleus oralis in the rat following experimental tooth movement

Yoshiaki Fujiyoshi, Takashi Yamashiro, Toru Deguchi, Tomosada Sugimoto, Teruko Takano-Yamamoto

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28 Citations (Scopus)

Abstract

The difference in temporal distribution of c-Fos-immunoreactivity (Fos-IR) was assessed in the medullary dorsal horn (MDH) and in the dorsomedial part of the trigeminal subnucleus oralis (Vodm) following experimental tooth movement of the rat maxillary molars. The number of MDH c-Fos-immunoreactive neurons increased bilaterally at 2 h and decreased markedly by 12 h, and then increased again with a small peak at 48 h. In contrast, Vodm c-Fos expression was not up-regulated until 12 h, but increased in number after 24 h, which increase lasted until 72 h. These findings indicate that experimental tooth movement induced nociceptive c-Fos response in a biphasic manner. Furthermore, the later response appeared after 24 h, and lasted for a few days, mainly manifested in the Vodm during experimental tooth movement. Copyright (C) 2000 Elsevier Science Ireland Ltd.

Original languageEnglish
Pages (from-to)205-208
Number of pages4
JournalNeuroscience Letters
Volume283
Issue number3
DOIs
Publication statusPublished - Apr 14 2000

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Keywords

  • c-Fos
  • Medullary dorsal horn
  • Nociception
  • Subnucleus oralis
  • Tooth movement
  • Two responses

ASJC Scopus subject areas

  • Neuroscience(all)

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