Abstract
Double applications of 12-O-tetradecanoylphorbol-13-acetate (TPA) to mouse skin at intervals of >48 h led to a larger induction of ornithine decarboxylase (ODC) and a smaller increase of DNA and RNA synthesis than did a single application. The largest induction of S-adenosylmethionine decarboxylase occurred at a 120 h interval between coupled TPA applications. The change in ODC activity was followed by a parallel change in putrescine level. At intervals
| Original language | English |
|---|---|
| Pages (from-to) | 5-7 |
| Number of pages | 3 |
| Journal | Carcinogenesis |
| Volume | 4 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - 1983 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Statistics, Probability and Uncertainty
- Applied Mathematics
- Physiology (medical)
- Physiology
- Behavioral Neuroscience
- Cancer Research
Cite this
The difference between the effects of single and double applications of 12-O-tetradecanoylphorbol-13-acetate, a potent tumor promoter, on polyamine metabolism and nucleic acid synthesis in mouse epidermis. / Takigawa, Masaharu; Simsiman, R. C.; Boutwell, R. K.
In: Carcinogenesis, Vol. 4, No. 1, 1983, p. 5-7.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - The difference between the effects of single and double applications of 12-O-tetradecanoylphorbol-13-acetate, a potent tumor promoter, on polyamine metabolism and nucleic acid synthesis in mouse epidermis
AU - Takigawa, Masaharu
AU - Simsiman, R. C.
AU - Boutwell, R. K.
PY - 1983
Y1 - 1983
N2 - Double applications of 12-O-tetradecanoylphorbol-13-acetate (TPA) to mouse skin at intervals of >48 h led to a larger induction of ornithine decarboxylase (ODC) and a smaller increase of DNA and RNA synthesis than did a single application. The largest induction of S-adenosylmethionine decarboxylase occurred at a 120 h interval between coupled TPA applications. The change in ODC activity was followed by a parallel change in putrescine level. At intervals
AB - Double applications of 12-O-tetradecanoylphorbol-13-acetate (TPA) to mouse skin at intervals of >48 h led to a larger induction of ornithine decarboxylase (ODC) and a smaller increase of DNA and RNA synthesis than did a single application. The largest induction of S-adenosylmethionine decarboxylase occurred at a 120 h interval between coupled TPA applications. The change in ODC activity was followed by a parallel change in putrescine level. At intervals
UR - http://www.scopus.com/inward/record.url?scp=0020526989&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0020526989&partnerID=8YFLogxK
U2 - 10.1093/carcin/4.1.5
DO - 10.1093/carcin/4.1.5
M3 - Article
C2 - 6185249
AN - SCOPUS:0020526989
VL - 4
SP - 5
EP - 7
JO - Carcinogenesis
JF - Carcinogenesis
SN - 0143-3334
IS - 1
ER -