The difference between the effects of single and double applications of 12-O-tetradecanoylphorbol-13-acetate, a potent tumor promoter, on polyamine metabolism and nucleic acid synthesis in mouse epidermis

Masaharu Takigawa, R. C. Simsiman, R. K. Boutwell

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

Double applications of 12-O-tetradecanoylphorbol-13-acetate (TPA) to mouse skin at intervals of >48 h led to a larger induction of ornithine decarboxylase (ODC) and a smaller increase of DNA and RNA synthesis than did a single application. The largest induction of S-adenosylmethionine decarboxylase occurred at a 120 h interval between coupled TPA applications. The change in ODC activity was followed by a parallel change in putrescine level. At intervals

Original languageEnglish
Pages (from-to)5-7
Number of pages3
JournalCarcinogenesis
Volume4
Issue number1
DOIs
Publication statusPublished - 1983
Externally publishedYes

Fingerprint

Polyamines
Epidermis
Ornithine Decarboxylase
Nucleic acids
Tetradecanoylphorbol Acetate
Promoter
Metabolism
Carcinogens
Nucleic Acids
Mouse
Tumors
Tumor
Adenosylmethionine Decarboxylase
Synthesis
Interval
Putrescine
Proof by induction
RNA Synthesis
RNA
Skin

ASJC Scopus subject areas

  • Statistics, Probability and Uncertainty
  • Applied Mathematics
  • Physiology (medical)
  • Physiology
  • Behavioral Neuroscience
  • Cancer Research

Cite this

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AU - Takigawa, Masaharu

AU - Simsiman, R. C.

AU - Boutwell, R. K.

PY - 1983

Y1 - 1983

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AB - Double applications of 12-O-tetradecanoylphorbol-13-acetate (TPA) to mouse skin at intervals of >48 h led to a larger induction of ornithine decarboxylase (ODC) and a smaller increase of DNA and RNA synthesis than did a single application. The largest induction of S-adenosylmethionine decarboxylase occurred at a 120 h interval between coupled TPA applications. The change in ODC activity was followed by a parallel change in putrescine level. At intervals

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