The defense response of Caenorhabditis elegans to Cutibacterium acnes SK137 via the TIR-1-p38 MAPK signaling pathway

Ayano Tsuru, Yumi Hamazaki, Shuta Tomida, Mohammad Shaokat Ali, Eriko Kage-Nakadai

Research output: Contribution to journalArticlepeer-review

Abstract

Cutibacterium acnes plays roles in both acne disease and healthy skin ecosystem. We observed that mutations in the tir-1/SARM1 and p38 MAPK cascade genes significantly shortened Caenorhabditis elegans lifespan upon C. acnes SK137 infection. Antimicrobial molecules were induced by SK137 in a TIR-1-dependent manner. These results suggest that defense responses against SK137 involve the TIR-1-p38 MAPK pathway in C. elegans.

Original languageEnglish
Pages (from-to)374-379
Number of pages6
JournalBioscience, Biotechnology and Biochemistry
Volume86
Issue number3
DOIs
Publication statusPublished - Mar 1 2022

Keywords

  • antimicrobial molecule
  • Caenorhabditis elegans
  • Cutibacterium acnes
  • p38 MAPK
  • tir-1

ASJC Scopus subject areas

  • Biotechnology
  • Analytical Chemistry
  • Biochemistry
  • Applied Microbiology and Biotechnology
  • Molecular Biology
  • Organic Chemistry

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