The cyclins: A family of widely expressed tumor antigens?

Michael S. Von Bergwelt-Baildon, Eisei Kondo, Nela Klein-Gonźlez, Clemens M. Wendtner

Research output: Contribution to journalReview articlepeer-review

10 Citations (Scopus)

Abstract

Continuous cell division is a hallmark of cancer and cell-cycle regulators therefore represent relevant target molecules for tumor therapy. Among these targets the cyclins are of particular interest as they are overexpressed in various tumor entities with little expression in normal tissue. Here we review evidence that these molecules are recognized by the immune system, summarize why cyclins A, B and D in particular appear to be interesting targets for active and passive immunotherapy, and discuss whether the entire family could be an interesting novel class of tumor antigens for cancer treatment and prevention.

Original languageEnglish
Pages (from-to)389-395
Number of pages7
JournalExpert Review of Vaccines
Volume10
Issue number3
DOIs
Publication statusPublished - Mar 2011
Externally publishedYes

Keywords

  • T-cell epitopes
  • active immunotherapy
  • cyclin
  • tumor antigens

ASJC Scopus subject areas

  • Immunology
  • Molecular Medicine
  • Pharmacology
  • Drug Discovery

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