The critical roles of serum/glucocorticoid-regulated kinase 3 (SGK3) in the hair follicle morphogenesis and homeostasis: The allelic difference provides novel insights into hair follicle biology

Taro Okada, Yoshiyuki Ishii, Kentaro Masujin, Akira Yasoshima, Junichiro Matsuda, Atsuo Ogura, Hiroyuki Nakayama, Tetsuo Kunieda, Kunio Doi

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Mutation in the serum/glucocorticoid regulated kinase 3 (Sgk3, also known as Sgkl or Cisk) gene causes both defective hair follicle development and altered hair cycle in mice. We examined Sgk3-mutant YPC mice (YPC-Sgk3 ypc/Sgk3ypc) and found expression of SGK3 protein with altered function. In the hair follicles of YPC mice, the aberrant differentiation and poor proliferation of hair matrix keratinocytes during the period of postnatal hair follicle development resulted in a complete lack of hair medulla and weak hair. Surprisingly, the length of postnatal hair follicle development and anagen term was shown to be dramatically shortened. Also, phosphorylation of GSK3β at Ser9 and the nuclear accumulation of β-catenin were reduced in the developing YPC hair follicle, suggesting that phosphorylation of GSK3β and WNT-β-catenin pathway takes part in the SGK3-dependent regulation of hair follicle development. Moreover, the above-mentioned features, especially the hair-cycling pattern, differ from those in other Sgk3-null mutant strains, suggesting that the various patterns of dysfunction in the SGK3 protein may result in phenotypic variation. Our results indicate that SGK3 is a very important and characteristic molecule that plays a critical role in both hair follicle morphogenesis and hair cycling.

Original languageEnglish
Pages (from-to)1119-1133
Number of pages15
JournalAmerican Journal of Pathology
Volume168
Issue number4
DOIs
Publication statusPublished - Apr 2006

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

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