The critical role of the antimicrobial peptide LL-37/ CRAMP in protection of colon microbiota balance, mucosal homeostasis, anti-inflammatory responses, and resistance to carcinogenesis

Meihua Zhang, Weiwei Liang, Wanghua Gong, Teizo Yoshimura, Keqiang Chen, Ji Ming Wang

Research output: Contribution to journalArticlepeer-review

8 Citations (Scopus)

Abstract

Mouse cathelin-related antimicrobial peptide (CRAMP) and its homologue human cathelicidin (LL-37) play active roles in innate immune responses, angiogenesis, and wound healing. In addition, LL-37/CRAMP fends off microbes and protects against infections in the colon, where the epithelium is exposed to myriad of enteric pathogens. It is increasingly recognized that LL-37/CRAMP maintains colon mucosal barrier integrity, shapes the composition of microbiota, and protects the host from tumorigenesis. In this review, we discuss the importance of LL-37/CRAMP in the homeostasis of the host, with novel findings derived from mice deficient in CRAMP that support the proposition for this natural antimicrobial peptide and an immune modulator as a drug lead for therapeutic development.

Original languageEnglish
Pages (from-to)83-92
Number of pages10
JournalCritical Reviews in Immunology
Volume39
Issue number2
DOIs
Publication statusPublished - 2019

Keywords

  • CRAMP
  • Cancer
  • Colitis
  • Homeostasis
  • Microbiota

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

Fingerprint

Dive into the research topics of 'The critical role of the antimicrobial peptide LL-37/ CRAMP in protection of colon microbiota balance, mucosal homeostasis, anti-inflammatory responses, and resistance to carcinogenesis'. Together they form a unique fingerprint.

Cite this