TY - JOUR
T1 - The co-expression of VR1 and VRL-1 in the rat vagal sensory ganglia
AU - Ichikawa, H.
AU - Sugimoto, T.
N1 - Funding Information:
We greatly appreciate Dr David Julius at the Department of Cellular and Molecular Pharmacology, University of California for his kind gift of the anti-VRL-1-serum. This work was supported by a grant from the Japanese Ministry of Education, Culture, Sports, Science and Technology to H.I. (No. 14571733).
PY - 2003/8/8
Y1 - 2003/8/8
N2 - Immunohistochemistry for two nociceptive transducers, the vanilloid receptor 1 (VR1) and vanilloid receptor 1-like receptor (VRL-1), was performed on the vagal sensory ganglia. In the jugular ganglion, VR1-immunoreactive (IR) neurons were small to medium-sized (range 49.7-1125.6 μm2, mean±S.D. 407.7±219.7 μm2), whereas VRL-1-IR neurons were medium-sized to large (range 223.6-1341.1 μm2, mean±S.D. 584.3±253.5 μm2). In the nodose ganglion, VR1- and VRL-1-IR neurons were mostly small to medium-sized (VR1: range 148.5-1464.4 μm2, mean±S.D. 554.3±207.4 μm2; VRL-1: range 161.7-1166.2 μm2, mean±S.D. 541.9±186.2 μm2). The double immunofluorescence method revealed that co-expression of VR1-immunoreactivity among VRL-1-IR neurons was more abundant in the nodose ganglion (63%) than in the jugular ganglion (4%). The present study suggests that co-expression of VR1 and VRL-1 may be more common in visceral sensory neurons than in somatic sensory neurons.
AB - Immunohistochemistry for two nociceptive transducers, the vanilloid receptor 1 (VR1) and vanilloid receptor 1-like receptor (VRL-1), was performed on the vagal sensory ganglia. In the jugular ganglion, VR1-immunoreactive (IR) neurons were small to medium-sized (range 49.7-1125.6 μm2, mean±S.D. 407.7±219.7 μm2), whereas VRL-1-IR neurons were medium-sized to large (range 223.6-1341.1 μm2, mean±S.D. 584.3±253.5 μm2). In the nodose ganglion, VR1- and VRL-1-IR neurons were mostly small to medium-sized (VR1: range 148.5-1464.4 μm2, mean±S.D. 554.3±207.4 μm2; VRL-1: range 161.7-1166.2 μm2, mean±S.D. 541.9±186.2 μm2). The double immunofluorescence method revealed that co-expression of VR1-immunoreactivity among VRL-1-IR neurons was more abundant in the nodose ganglion (63%) than in the jugular ganglion (4%). The present study suggests that co-expression of VR1 and VRL-1 may be more common in visceral sensory neurons than in somatic sensory neurons.
KW - Cell size
KW - Immunohistochemistry
KW - Jugular ganglion
KW - Nodose ganglion
KW - Vanilloid receptor 1
KW - Vanilloid receptor 1-like receptor
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U2 - 10.1016/S0006-8993(03)02998-6
DO - 10.1016/S0006-8993(03)02998-6
M3 - Article
C2 - 12867271
AN - SCOPUS:0037966121
VL - 980
SP - 293
EP - 296
JO - Molecular Brain Research
JF - Molecular Brain Research
SN - 0006-8993
IS - 2
ER -