The clinicopathological differences of sporadic non-ampullary duodenal epithelial neoplasm depending on tumor location

Katsunori Matsueda, Hiromitsu Kanzaki, Kazuhiro Matsueda, Junichiro Nasu, Masao Yoshioka, Masahiro Nakagawa, Masafumi Inoue, Tomoki Inaba, Atsushi Imagawa, Masahiro Takatani, Ryuta Takenaka, Seiyu Suzuki, Jun Tomoda, Takahito Yagi, Toshiyoshi Fujiwara, Takehiro Tanaka, Hiroyuki Okada

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1 Citation (Scopus)

Abstract

Background and Aim: Although sporadic non-ampullary duodenal adenoma is speculated to be precancerous lesion, the relationship between adenoma and carcinoma remains unclear due to their rarity. Previous studies on sporadic non-ampullary duodenal epithelial neoplasm (SNADEN) have mainly targeted superficial tumors, like adenoma and early carcinoma. The clinicopathological features, including those of advanced carcinoma, remain poorly investigated. We assessed the clinicopathological features of SNADEN, including advanced carcinoma, focusing on tumor location. Methods: We retrospectively collected the data of 410 patients who had been clinically and pathologically diagnosed with SNADEN at 11 institutions in Japan between June 2002 and March 2014. Results: The SNADEN was mucosal neoplasia and invasive carcinoma in 321 (78.3%) and 89 (21.7%) patients, respectively. The proportion of invasive carcinomas in SNADEN was significantly higher on the oral side of the papilla of Vater (oral-Vater) than on the anal side (anal-Vater) (27.9% vs 14.4%, P < 0.001). Undifferentiated-type carcinoma was significantly more frequent with oral-Vater than anal-Vater (38.7% vs 14.8%, P = 0.026). The recurrence rate of surgically R0 resected locally advanced carcinomas was significantly higher with oral-Vater than anal-Vater (46.4% vs 8.3%, P = 0.021). Furthermore, the relapse-free survival with oral-Vater was significantly shorter than with anal-Vater (hazard ratio: 2.35; 95% confidence interval: 1.09–5.50; P = 0.028). Conclusions: The clinicopathological features of SNADEN on oral-Vater were different from those on anal-Vater. SNADEN on oral-Vater was more likely to be invasive carcinomas and might behave more aggressively due to biologically higher malignancy than that on anal-Vater.

Original languageEnglish
JournalJournal of Gastroenterology and Hepatology (Australia)
DOIs
Publication statusPublished - Jan 1 2019

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Duodenal Neoplasms
Glandular and Epithelial Neoplasms
Carcinoma
Neoplasms
Adenoma
Recurrence
Japan
Confidence Intervals

Keywords

  • clinicopathological differences
  • sporadic non-ampullary duodenal epithelial neoplasm (SNADEN)
  • tumor location

ASJC Scopus subject areas

  • Hepatology
  • Gastroenterology

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The clinicopathological differences of sporadic non-ampullary duodenal epithelial neoplasm depending on tumor location. / Matsueda, Katsunori; Kanzaki, Hiromitsu; Matsueda, Kazuhiro; Nasu, Junichiro; Yoshioka, Masao; Nakagawa, Masahiro; Inoue, Masafumi; Inaba, Tomoki; Imagawa, Atsushi; Takatani, Masahiro; Takenaka, Ryuta; Suzuki, Seiyu; Tomoda, Jun; Yagi, Takahito; Fujiwara, Toshiyoshi; Tanaka, Takehiro; Okada, Hiroyuki.

In: Journal of Gastroenterology and Hepatology (Australia), 01.01.2019.

Research output: Contribution to journalArticle

Matsueda, Katsunori ; Kanzaki, Hiromitsu ; Matsueda, Kazuhiro ; Nasu, Junichiro ; Yoshioka, Masao ; Nakagawa, Masahiro ; Inoue, Masafumi ; Inaba, Tomoki ; Imagawa, Atsushi ; Takatani, Masahiro ; Takenaka, Ryuta ; Suzuki, Seiyu ; Tomoda, Jun ; Yagi, Takahito ; Fujiwara, Toshiyoshi ; Tanaka, Takehiro ; Okada, Hiroyuki. / The clinicopathological differences of sporadic non-ampullary duodenal epithelial neoplasm depending on tumor location. In: Journal of Gastroenterology and Hepatology (Australia). 2019.
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abstract = "Background and Aim: Although sporadic non-ampullary duodenal adenoma is speculated to be precancerous lesion, the relationship between adenoma and carcinoma remains unclear due to their rarity. Previous studies on sporadic non-ampullary duodenal epithelial neoplasm (SNADEN) have mainly targeted superficial tumors, like adenoma and early carcinoma. The clinicopathological features, including those of advanced carcinoma, remain poorly investigated. We assessed the clinicopathological features of SNADEN, including advanced carcinoma, focusing on tumor location. Methods: We retrospectively collected the data of 410 patients who had been clinically and pathologically diagnosed with SNADEN at 11 institutions in Japan between June 2002 and March 2014. Results: The SNADEN was mucosal neoplasia and invasive carcinoma in 321 (78.3{\%}) and 89 (21.7{\%}) patients, respectively. The proportion of invasive carcinomas in SNADEN was significantly higher on the oral side of the papilla of Vater (oral-Vater) than on the anal side (anal-Vater) (27.9{\%} vs 14.4{\%}, P < 0.001). Undifferentiated-type carcinoma was significantly more frequent with oral-Vater than anal-Vater (38.7{\%} vs 14.8{\%}, P = 0.026). The recurrence rate of surgically R0 resected locally advanced carcinomas was significantly higher with oral-Vater than anal-Vater (46.4{\%} vs 8.3{\%}, P = 0.021). Furthermore, the relapse-free survival with oral-Vater was significantly shorter than with anal-Vater (hazard ratio: 2.35; 95{\%} confidence interval: 1.09–5.50; P = 0.028). Conclusions: The clinicopathological features of SNADEN on oral-Vater were different from those on anal-Vater. SNADEN on oral-Vater was more likely to be invasive carcinomas and might behave more aggressively due to biologically higher malignancy than that on anal-Vater.",
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AU - Matsueda, Katsunori

AU - Kanzaki, Hiromitsu

AU - Matsueda, Kazuhiro

AU - Nasu, Junichiro

AU - Yoshioka, Masao

AU - Nakagawa, Masahiro

AU - Inoue, Masafumi

AU - Inaba, Tomoki

AU - Imagawa, Atsushi

AU - Takatani, Masahiro

AU - Takenaka, Ryuta

AU - Suzuki, Seiyu

AU - Tomoda, Jun

AU - Yagi, Takahito

AU - Fujiwara, Toshiyoshi

AU - Tanaka, Takehiro

AU - Okada, Hiroyuki

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N2 - Background and Aim: Although sporadic non-ampullary duodenal adenoma is speculated to be precancerous lesion, the relationship between adenoma and carcinoma remains unclear due to their rarity. Previous studies on sporadic non-ampullary duodenal epithelial neoplasm (SNADEN) have mainly targeted superficial tumors, like adenoma and early carcinoma. The clinicopathological features, including those of advanced carcinoma, remain poorly investigated. We assessed the clinicopathological features of SNADEN, including advanced carcinoma, focusing on tumor location. Methods: We retrospectively collected the data of 410 patients who had been clinically and pathologically diagnosed with SNADEN at 11 institutions in Japan between June 2002 and March 2014. Results: The SNADEN was mucosal neoplasia and invasive carcinoma in 321 (78.3%) and 89 (21.7%) patients, respectively. The proportion of invasive carcinomas in SNADEN was significantly higher on the oral side of the papilla of Vater (oral-Vater) than on the anal side (anal-Vater) (27.9% vs 14.4%, P < 0.001). Undifferentiated-type carcinoma was significantly more frequent with oral-Vater than anal-Vater (38.7% vs 14.8%, P = 0.026). The recurrence rate of surgically R0 resected locally advanced carcinomas was significantly higher with oral-Vater than anal-Vater (46.4% vs 8.3%, P = 0.021). Furthermore, the relapse-free survival with oral-Vater was significantly shorter than with anal-Vater (hazard ratio: 2.35; 95% confidence interval: 1.09–5.50; P = 0.028). Conclusions: The clinicopathological features of SNADEN on oral-Vater were different from those on anal-Vater. SNADEN on oral-Vater was more likely to be invasive carcinomas and might behave more aggressively due to biologically higher malignancy than that on anal-Vater.

AB - Background and Aim: Although sporadic non-ampullary duodenal adenoma is speculated to be precancerous lesion, the relationship between adenoma and carcinoma remains unclear due to their rarity. Previous studies on sporadic non-ampullary duodenal epithelial neoplasm (SNADEN) have mainly targeted superficial tumors, like adenoma and early carcinoma. The clinicopathological features, including those of advanced carcinoma, remain poorly investigated. We assessed the clinicopathological features of SNADEN, including advanced carcinoma, focusing on tumor location. Methods: We retrospectively collected the data of 410 patients who had been clinically and pathologically diagnosed with SNADEN at 11 institutions in Japan between June 2002 and March 2014. Results: The SNADEN was mucosal neoplasia and invasive carcinoma in 321 (78.3%) and 89 (21.7%) patients, respectively. The proportion of invasive carcinomas in SNADEN was significantly higher on the oral side of the papilla of Vater (oral-Vater) than on the anal side (anal-Vater) (27.9% vs 14.4%, P < 0.001). Undifferentiated-type carcinoma was significantly more frequent with oral-Vater than anal-Vater (38.7% vs 14.8%, P = 0.026). The recurrence rate of surgically R0 resected locally advanced carcinomas was significantly higher with oral-Vater than anal-Vater (46.4% vs 8.3%, P = 0.021). Furthermore, the relapse-free survival with oral-Vater was significantly shorter than with anal-Vater (hazard ratio: 2.35; 95% confidence interval: 1.09–5.50; P = 0.028). Conclusions: The clinicopathological features of SNADEN on oral-Vater were different from those on anal-Vater. SNADEN on oral-Vater was more likely to be invasive carcinomas and might behave more aggressively due to biologically higher malignancy than that on anal-Vater.

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