The Classification of Glomerulonephritis in Systemic Lupus Erythematosus Revisited

Jan J. Weening, Vivette D. D'Agati, Melvin M. Schwartz, Surya V. Seshan, Charles E. Alpers, Gerald B. Appel, James E. Balow, Jan A. Bruijn, Terence Cook, Franco Ferrario, Agnes B. Fogo, Ellen M. Ginzler, Lee Hebert, Gary Hill, Prue Hill, J. Charles Jennette, Norella C. Kong, Philippe Lesavre, Michael Lockshin, Lai Meng LooiHirofumi Makino, Luiz A. Moura, Michio Nagata

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1232 Citations (Scopus)

Abstract

The currently used classification reflects our understanding of the pathogenesis of the various forms of lupus nephritis, but clinicopathologic studies have revealed the need for improved categorization and terminology. Based on the 1982 classification published under the auspices of the World Health Organization (WHO) and subsequent clinicopathologic data, we propose that class I and II be used for purely mesangial involvement (I, mesangial immune deposits without mesangial hypercellularity; II, mesangial immune deposits with mesangial hypercellularity); class III for focal glomerulonephritis (involving <50% of total number of glomeruli) with subdivisions for active and sclerotic lesions; class IV for diffuse glomerulonephritis (involving ≥50% of total number of glomeruli) either with segmental (class IV-S) or global (class IV-G) involvement, and also with subdivisions for active and sclerotic lesions; class V for membranous lupus nephritis; and class VI for advanced sclerosing lesions]. Combinations of membranous and proliferative glomerulonephritis (i.e., class III and V or class IV and V) should be reported individually in the diagnostic line. The diagnosis should also include entries for any concomitant vascular or tubulointerstitial lesions. One of the main advantages of the current revised classification is that it provides a clear and unequivocal description of the various lesions and classes of lupus nephritis, allowing a better standardization and lending a basis for further clinicopathologic studies. We hope that this revision, which evolved under the auspices of the Intemational Society of Nephrology and the Renal Pathology Society, will contribute to further advancement of the WHO classification.

Original languageEnglish
Pages (from-to)241-250
Number of pages10
JournalJournal of the American Society of Nephrology
Volume15
Issue number2
DOIs
Publication statusPublished - Feb 2004

ASJC Scopus subject areas

  • Nephrology

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    Weening, J. J., D'Agati, V. D., Schwartz, M. M., Seshan, S. V., Alpers, C. E., Appel, G. B., Balow, J. E., Bruijn, J. A., Cook, T., Ferrario, F., Fogo, A. B., Ginzler, E. M., Hebert, L., Hill, G., Hill, P., Jennette, J. C., Kong, N. C., Lesavre, P., Lockshin, M., ... Nagata, M. (2004). The Classification of Glomerulonephritis in Systemic Lupus Erythematosus Revisited. Journal of the American Society of Nephrology, 15(2), 241-250. https://doi.org/10.1097/01.ASN.0000108969.21691.5D