The characteristics and outcomes of small bowel adenocarcinoma

A multicentre retrospective observational study

Hiroyuki Sakae, Hiromitsu Kanzaki, Junichiro Nasu, Yutaka Akimoto, Kazuhiro Matsueda, Masao Yoshioka, Masahiro Nakagawa, Shinichiro Hori, Masafumi Inoue, Tomoki Inaba, Atsushi Imagawa, Masahiro Takatani, Ryuta Takenaka, Seiyu Suzuki, Toshiyoshi Fujiwara, Hiroyuki Okada

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Background:Small bowel adenocarcinoma (SBA) is a rare malignancy that accounts for 1-2% of gastrointestinal tumours. We investigated the clinical characteristics, outcomes, and prognostic factors of primary SBA.Methods:We retrospectively analysed the characteristics and clinical courses of 205 SBA patients from 11 institutions in Japan between June 2002 and August 2013.Results:The primary tumour was in the duodenum and jejunum/ileum in 149 (72.7%) and 56 (27.3%) patients, respectively. Sixty-four patients (43.0%) with duodenal adenocarcinoma were asymptomatic and most cases were detected by oesophagogastroduodenoscopy (EGD), which was not specifically performed for the detection or surveillance of duodenal tumours. In contrast, 47 patients (83.9%) with jejunoileal carcinoma were symptomatic. The 3-year survival rate for stage 0/I, II, III, and IV cancers was 93.4%, 73.1%, 50.9%, and 15.1%, respectively. Multivariate analysis revealed performance status 3-4, high carcinoembryonic antigen, high lactate dehydrogenase (LDH), low albumin, symptomatic at diagnosis, and stage III/IV disease were independent factors for overall survival (OS). Ten patients (18.5%) with stage IV disease were treated with a combination of resection of primary tumour, local treatment of metastasis, and chemotherapy; this group had a median OS of 36.9 months.Conclusions:Although most SBA patients were diagnosed with symptomatic, advanced stage disease, some patients with duodenal carcinoma were detected in early stage by EGD. High LDH and symptomatic at diagnosis were identified as novel independent prognostic factors for OS. The prognosis of advanced SBA was poor, but combined modality therapy with local treatment of metastasis might prolong patient survival.

Original languageEnglish
Pages (from-to)1607-1613
Number of pages7
JournalBritish Journal of Cancer
Volume117
Issue number11
DOIs
Publication statusPublished - Nov 21 2017

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Observational Studies
Adenocarcinoma
Retrospective Studies
Neoplasms
Survival
L-Lactate Dehydrogenase
Neoplasm Metastasis
Digestive System Endoscopy
Carcinoma
Combined Modality Therapy
Carcinoembryonic Antigen
Jejunum
Ileum
Duodenum
Albumins
Japan
Multivariate Analysis
Survival Rate
Drug Therapy
Therapeutics

Keywords

  • adenocarcinoma
  • small bowel
  • small intestine

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

The characteristics and outcomes of small bowel adenocarcinoma : A multicentre retrospective observational study. / Sakae, Hiroyuki; Kanzaki, Hiromitsu; Nasu, Junichiro; Akimoto, Yutaka; Matsueda, Kazuhiro; Yoshioka, Masao; Nakagawa, Masahiro; Hori, Shinichiro; Inoue, Masafumi; Inaba, Tomoki; Imagawa, Atsushi; Takatani, Masahiro; Takenaka, Ryuta; Suzuki, Seiyu; Fujiwara, Toshiyoshi; Okada, Hiroyuki.

In: British Journal of Cancer, Vol. 117, No. 11, 21.11.2017, p. 1607-1613.

Research output: Contribution to journalArticle

Sakae, H, Kanzaki, H, Nasu, J, Akimoto, Y, Matsueda, K, Yoshioka, M, Nakagawa, M, Hori, S, Inoue, M, Inaba, T, Imagawa, A, Takatani, M, Takenaka, R, Suzuki, S, Fujiwara, T & Okada, H 2017, 'The characteristics and outcomes of small bowel adenocarcinoma: A multicentre retrospective observational study', British Journal of Cancer, vol. 117, no. 11, pp. 1607-1613. https://doi.org/10.1038/bjc.2017.338
Sakae, Hiroyuki ; Kanzaki, Hiromitsu ; Nasu, Junichiro ; Akimoto, Yutaka ; Matsueda, Kazuhiro ; Yoshioka, Masao ; Nakagawa, Masahiro ; Hori, Shinichiro ; Inoue, Masafumi ; Inaba, Tomoki ; Imagawa, Atsushi ; Takatani, Masahiro ; Takenaka, Ryuta ; Suzuki, Seiyu ; Fujiwara, Toshiyoshi ; Okada, Hiroyuki. / The characteristics and outcomes of small bowel adenocarcinoma : A multicentre retrospective observational study. In: British Journal of Cancer. 2017 ; Vol. 117, No. 11. pp. 1607-1613.
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abstract = "Background:Small bowel adenocarcinoma (SBA) is a rare malignancy that accounts for 1-2{\%} of gastrointestinal tumours. We investigated the clinical characteristics, outcomes, and prognostic factors of primary SBA.Methods:We retrospectively analysed the characteristics and clinical courses of 205 SBA patients from 11 institutions in Japan between June 2002 and August 2013.Results:The primary tumour was in the duodenum and jejunum/ileum in 149 (72.7{\%}) and 56 (27.3{\%}) patients, respectively. Sixty-four patients (43.0{\%}) with duodenal adenocarcinoma were asymptomatic and most cases were detected by oesophagogastroduodenoscopy (EGD), which was not specifically performed for the detection or surveillance of duodenal tumours. In contrast, 47 patients (83.9{\%}) with jejunoileal carcinoma were symptomatic. The 3-year survival rate for stage 0/I, II, III, and IV cancers was 93.4{\%}, 73.1{\%}, 50.9{\%}, and 15.1{\%}, respectively. Multivariate analysis revealed performance status 3-4, high carcinoembryonic antigen, high lactate dehydrogenase (LDH), low albumin, symptomatic at diagnosis, and stage III/IV disease were independent factors for overall survival (OS). Ten patients (18.5{\%}) with stage IV disease were treated with a combination of resection of primary tumour, local treatment of metastasis, and chemotherapy; this group had a median OS of 36.9 months.Conclusions:Although most SBA patients were diagnosed with symptomatic, advanced stage disease, some patients with duodenal carcinoma were detected in early stage by EGD. High LDH and symptomatic at diagnosis were identified as novel independent prognostic factors for OS. The prognosis of advanced SBA was poor, but combined modality therapy with local treatment of metastasis might prolong patient survival.",
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T1 - The characteristics and outcomes of small bowel adenocarcinoma

T2 - A multicentre retrospective observational study

AU - Sakae, Hiroyuki

AU - Kanzaki, Hiromitsu

AU - Nasu, Junichiro

AU - Akimoto, Yutaka

AU - Matsueda, Kazuhiro

AU - Yoshioka, Masao

AU - Nakagawa, Masahiro

AU - Hori, Shinichiro

AU - Inoue, Masafumi

AU - Inaba, Tomoki

AU - Imagawa, Atsushi

AU - Takatani, Masahiro

AU - Takenaka, Ryuta

AU - Suzuki, Seiyu

AU - Fujiwara, Toshiyoshi

AU - Okada, Hiroyuki

PY - 2017/11/21

Y1 - 2017/11/21

N2 - Background:Small bowel adenocarcinoma (SBA) is a rare malignancy that accounts for 1-2% of gastrointestinal tumours. We investigated the clinical characteristics, outcomes, and prognostic factors of primary SBA.Methods:We retrospectively analysed the characteristics and clinical courses of 205 SBA patients from 11 institutions in Japan between June 2002 and August 2013.Results:The primary tumour was in the duodenum and jejunum/ileum in 149 (72.7%) and 56 (27.3%) patients, respectively. Sixty-four patients (43.0%) with duodenal adenocarcinoma were asymptomatic and most cases were detected by oesophagogastroduodenoscopy (EGD), which was not specifically performed for the detection or surveillance of duodenal tumours. In contrast, 47 patients (83.9%) with jejunoileal carcinoma were symptomatic. The 3-year survival rate for stage 0/I, II, III, and IV cancers was 93.4%, 73.1%, 50.9%, and 15.1%, respectively. Multivariate analysis revealed performance status 3-4, high carcinoembryonic antigen, high lactate dehydrogenase (LDH), low albumin, symptomatic at diagnosis, and stage III/IV disease were independent factors for overall survival (OS). Ten patients (18.5%) with stage IV disease were treated with a combination of resection of primary tumour, local treatment of metastasis, and chemotherapy; this group had a median OS of 36.9 months.Conclusions:Although most SBA patients were diagnosed with symptomatic, advanced stage disease, some patients with duodenal carcinoma were detected in early stage by EGD. High LDH and symptomatic at diagnosis were identified as novel independent prognostic factors for OS. The prognosis of advanced SBA was poor, but combined modality therapy with local treatment of metastasis might prolong patient survival.

AB - Background:Small bowel adenocarcinoma (SBA) is a rare malignancy that accounts for 1-2% of gastrointestinal tumours. We investigated the clinical characteristics, outcomes, and prognostic factors of primary SBA.Methods:We retrospectively analysed the characteristics and clinical courses of 205 SBA patients from 11 institutions in Japan between June 2002 and August 2013.Results:The primary tumour was in the duodenum and jejunum/ileum in 149 (72.7%) and 56 (27.3%) patients, respectively. Sixty-four patients (43.0%) with duodenal adenocarcinoma were asymptomatic and most cases were detected by oesophagogastroduodenoscopy (EGD), which was not specifically performed for the detection or surveillance of duodenal tumours. In contrast, 47 patients (83.9%) with jejunoileal carcinoma were symptomatic. The 3-year survival rate for stage 0/I, II, III, and IV cancers was 93.4%, 73.1%, 50.9%, and 15.1%, respectively. Multivariate analysis revealed performance status 3-4, high carcinoembryonic antigen, high lactate dehydrogenase (LDH), low albumin, symptomatic at diagnosis, and stage III/IV disease were independent factors for overall survival (OS). Ten patients (18.5%) with stage IV disease were treated with a combination of resection of primary tumour, local treatment of metastasis, and chemotherapy; this group had a median OS of 36.9 months.Conclusions:Although most SBA patients were diagnosed with symptomatic, advanced stage disease, some patients with duodenal carcinoma were detected in early stage by EGD. High LDH and symptomatic at diagnosis were identified as novel independent prognostic factors for OS. The prognosis of advanced SBA was poor, but combined modality therapy with local treatment of metastasis might prolong patient survival.

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