The Changes of Hepatic Metallothionein Synthesis and the Hepatic Damage Induced by Starvation in Mice

N. Sogawa, C. A. Sogawa, H. Fukuoka, Y. Mukubo, T. Yoneyama, Y. Okano, H. Furuta, Kenji Onodera

Research output: Contribution to journalArticlepeer-review

10 Citations (Scopus)

Abstract

Metallothionein (MT) is induced in the liver not only by heavy metals, but also by stress such as starvation. However the meaning of the induced MT during starvation has never been clear. In this study, we investigated the relationship between changes in hepatic MT synthesis and the hepatic damage that occurs during starvation. MT synthesis was assessed by measuring MT contents and the expression of the MT gene in the liver. The hepatic damage was assessed by measuring glutamic pyruvic transaminase (GPT) and glutamic oxaloacetic transaminase (GOT) activities in the serum. MT synthesis in the liver increased over the normal level by starvation, but decreased under the normal level by refeeding after starvation. Both GPT and GOT activities of the refeeding group were higher than those of the control group. However, MT synthesis increased by a subcutaneous injection with CdCl2 (1 mg Cd/kg) at the same time as refeeding after starvation. At this point, GOT activity decreased until it reached the normal level. MT synthesis decreased by refeeding after starvation, and from the results found in this study, we proposed the hypothesis that the liver damage caused by refeeding after starvation might be due to the decrease in the synthesis of a sufficient amount of MT induced by metals.

Original languageEnglish
Pages (from-to)601-606
Number of pages6
JournalMethods and Findings in Experimental and Clinical Pharmacology
Volume25
Issue number8
DOIs
Publication statusPublished - Oct 2003

Keywords

  • Hepatic damage
  • Metallothionein
  • Starvation

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)

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