The CD38/NAD/SIRTUIN1/EZH2 Axis Mitigates Cytotoxic CD8 T Cell Function and Identifies Patients with SLE Prone to Infections

Eri Katsuyama, Abel Suarez-Fueyo, Sean J. Bradley, Masayuki Mizui, Ana V. Marin, Lama Mulki, Suzanne Krishfield, Fabio Malavasi, Joon Yoon, Shannan J.Ho Sui, Vasileios C. Kyttaris, George C. Tsokos

Research output: Contribution to journalArticlepeer-review

39 Citations (Scopus)

Abstract

Katsuyama et al. find that an expanded CD8CD38high T cell population in SLE patients is linked to infections. CD8CD38high T cells display decreased cytotoxic capacity by suppressing the expression of related molecules through an NAD+/Sirtuin1/EZH2 pathway. EZH2 inhibitors increase cytotoxicity offering a means to mitigate infection rates in SLE.

Original languageEnglish
Pages (from-to)112-123.e4
JournalCell Reports
Volume30
Issue number1
DOIs
Publication statusPublished - Jan 7 2020
Externally publishedYes

Keywords

  • CD38
  • CD8 T cell
  • cytotoxicity
  • EZH2
  • infection
  • nicotinamide adenine dinucleotide
  • patients
  • Sirtuin1
  • systemic lupus erythematosus

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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