The catalytic activity of glass beads, silica gels and anion-exchange resins modified with metal-porphines in the oxidative reaction of NADH

Akimasa Iwado; Masaki Mifune; Rumiko Harada; Junko Oda; Noriko Motohashi; Yutaka Saito

doi:10.1248/cpb.47.1301

The catalytic activity of glass beads, silica gels and anion-exchange resins modified with metal-porphines in the oxidative reaction of NADH

Akimasa Iwado, Masaki Mifune, Rumiko Harada, Junko Oda, Noriko Motohashi, Yutaka Saito

Research output: Contribution to journal › Article › peer-review

5 Citations (Scopus)

Abstract

Silica gel and glass beads were modified using the acid chloride of metal-tetrakis(4-carboxyphenyl)porphine (M-TCPP) through a peptide bond, and an anion-exchange resin was modified with M-TCPP by electrostatic interaction and physical adsorption. The carriers modified with Co³⁺-TCPP proved to accelerate the following redox reaction: NADH ⁺ O₂ carriers modified with Co-TCPP NADH⁺H₂O₂. The formation of hydrogen peroxide was confirmed by means of a colored reaction. The glass heads modified with Co³⁺-TCPP exhibited the strongest activity among the tested carriers, and were expected to be useful practically as a solid catalyst for the formation of hydrogen peroxide from NADH.

Original language	English
Pages (from-to)	1301-1304
Number of pages	4
Journal	Chemical and Pharmaceutical Bulletin
Volume	47
Issue number	9
DOIs	https://doi.org/10.1248/cpb.47.1301
Publication status	Published - Sep 1999

Keywords

Determination
Hydrogen peroxide
Metal-porphine
Modified carrier
NADH
Oxidative catalysis

ASJC Scopus subject areas

Chemistry(all)
Drug Discovery

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10.1248/cpb.47.1301

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title = "The catalytic activity of glass beads, silica gels and anion-exchange resins modified with metal-porphines in the oxidative reaction of NADH",

abstract = "Silica gel and glass beads were modified using the acid chloride of metal-tetrakis(4-carboxyphenyl)porphine (M-TCPP) through a peptide bond, and an anion-exchange resin was modified with M-TCPP by electrostatic interaction and physical adsorption. The carriers modified with Co3+-TCPP proved to accelerate the following redox reaction: NADH + O2 carriers modified with Co-TCPP NADH+H2O2. The formation of hydrogen peroxide was confirmed by means of a colored reaction. The glass heads modified with Co3+-TCPP exhibited the strongest activity among the tested carriers, and were expected to be useful practically as a solid catalyst for the formation of hydrogen peroxide from NADH.",

keywords = "Determination, Hydrogen peroxide, Metal-porphine, Modified carrier, NADH, Oxidative catalysis",

author = "Akimasa Iwado and Masaki Mifune and Rumiko Harada and Junko Oda and Noriko Motohashi and Yutaka Saito",

year = "1999",

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TY - JOUR

T1 - The catalytic activity of glass beads, silica gels and anion-exchange resins modified with metal-porphines in the oxidative reaction of NADH

AU - Iwado, Akimasa

AU - Mifune, Masaki

AU - Harada, Rumiko

AU - Oda, Junko

AU - Motohashi, Noriko

AU - Saito, Yutaka

PY - 1999/9

Y1 - 1999/9

N2 - Silica gel and glass beads were modified using the acid chloride of metal-tetrakis(4-carboxyphenyl)porphine (M-TCPP) through a peptide bond, and an anion-exchange resin was modified with M-TCPP by electrostatic interaction and physical adsorption. The carriers modified with Co3+-TCPP proved to accelerate the following redox reaction: NADH + O2 carriers modified with Co-TCPP NADH+H2O2. The formation of hydrogen peroxide was confirmed by means of a colored reaction. The glass heads modified with Co3+-TCPP exhibited the strongest activity among the tested carriers, and were expected to be useful practically as a solid catalyst for the formation of hydrogen peroxide from NADH.

AB - Silica gel and glass beads were modified using the acid chloride of metal-tetrakis(4-carboxyphenyl)porphine (M-TCPP) through a peptide bond, and an anion-exchange resin was modified with M-TCPP by electrostatic interaction and physical adsorption. The carriers modified with Co3+-TCPP proved to accelerate the following redox reaction: NADH + O2 carriers modified with Co-TCPP NADH+H2O2. The formation of hydrogen peroxide was confirmed by means of a colored reaction. The glass heads modified with Co3+-TCPP exhibited the strongest activity among the tested carriers, and were expected to be useful practically as a solid catalyst for the formation of hydrogen peroxide from NADH.

KW - Determination

KW - Hydrogen peroxide

KW - Metal-porphine

KW - Modified carrier

KW - NADH

KW - Oxidative catalysis

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DO - 10.1248/cpb.47.1301

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VL - 47

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EP - 1304

JO - Chemical and Pharmaceutical Bulletin

JF - Chemical and Pharmaceutical Bulletin

SN - 0009-2363

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The catalytic activity of glass beads, silica gels and anion-exchange resins modified with metal-porphines in the oxidative reaction of NADH

Abstract

Keywords

ASJC Scopus subject areas

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