The association of coffee consumption and oxygen desaturation index during sleep among Japanese male workers

Asuka Takabayashi, Koutatsu Maruyama, Yasuhiko Tanno, Susumu Sakurai, Eri Eguchi, Hiroo Wada, Ryutaro Shirahama, Isao Saito, Takeshi Tanigawa

Research output: Contribution to journalArticlepeer-review

4 Citations (Scopus)


Background and objective: Coffee is a major caffeine-containing food source that can be used for treatment of apnea in prematurity. However, few studies have examined the association between coffee consumption and sleep-disordered breathing (SDB). We investigated whether coffee consumption is associated with the oxygen desaturation index (ODI) as a marker of SDB among middle-aged Japanese male workers. Methods: The subjects were 1126 male local government workers aged 22–59 who participated in SDB screening in 2011–2012. Daily coffee consumption was assessed by a self-administered questionnaire. We measured 3% oxygen desaturation (3%ODI) during a night’s sleep using a pulse oximeter. A general linear model was used to calculate the multivariate-adjusted means of 3%ODI per quartile of coffee consumption. We further analyzed the data after stratifying by overweight and current smoking status. Results: A inverse association between coffee consumption and 3%ODI was found. The multivariate-adjusted mean of 3%ODI for the lowest and highest coffee consumption groups were 11.9 times/h and 10.6 times/h (p for trend = 0.06), respectively; 14.6 and 11.5 times/h (p for trend = 0.01) in overweight participants; and 12.7 and 11.0 times/h (p for trend = 0.06) in non-smokers. No associations were found in non-overweight and smoking workers. Conclusions: Our results suggest that higher coffee consumption was associated with lower 3% ODI as a marker of SDB in overweight and non-smoking workers.

Original languageEnglish
Pages (from-to)1027-1031
Number of pages5
JournalSleep and Breathing
Issue number4
Publication statusPublished - Dec 1 2019


  • 3%ODI
  • Coffee
  • Cross-sectional study
  • Japanese male worker
  • SDB

ASJC Scopus subject areas

  • Otorhinolaryngology
  • Clinical Neurology


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