The association of antibodies against human T cell lymphotropic virus type I (HTLV-I) pX gene mutant products with HTLV-I-associated myelopathy/tropical spastic paraparesis

Jun Suzuki, Jun Ichi Kira, Eishi Baba, Minoru Nakamura, Yoshio Koyanagi, Tatsufumi Nakamura, Yuji Kawano, Kenji Yamasaki, Susumu Shirabe, Naoya Hatano, Kenshi Hayashi, Naoki Yamamoto, Takuro Kobayashi

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Antibodies specific for the products of the human T cell lymphotropic virus type 1 (HTLV-I) pX frame-shift mutants were studied by ELISA. The serum IgG antibodies to the synthetic peptide corresponding to one nucleotide insertion at position 7784 were significantly more common in patients with HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) patients than in HTLV-I carriers who had neither HAM/TSP nor adult T cell leukemia (39% vs. 5%). The seropositivities to the other synthetic peptides, which corresponded to the one nucleotide deletion at position 7475 and the internal deletion of nt 7754-7819 and nt 7853-7936, were rare. A genetic study confirmed the presence of the responsible mutation of the pX gene in peripheral blood mononuclear cells and central nervous system tissue from HTLV-I-infected subjects with and without HAM/TSP. These results suggest that HTLV-I pX frame-shift mutants are expressed in vivo in HTLV-I carriers; they also induce antibodies, especially in those with HAM/TSP.

Original languageEnglish
Pages (from-to)1115-1122
Number of pages8
JournalJournal of Infectious Diseases
Volume173
Issue number5
DOIs
Publication statusPublished - Jan 1 1996
Externally publishedYes

Fingerprint

pX Genes
Tropical Spastic Paraparesis
Human T-lymphotropic virus 1
Spinal Cord Diseases
Viruses
T-Lymphocytes
Antibodies
Nucleotides
Nerve Tissue
Adult T Cell Leukemia Lymphoma
Peptides
Blood Cells
Central Nervous System
Immunoglobulin G
Enzyme-Linked Immunosorbent Assay
Mutation
Serum

ASJC Scopus subject areas

  • Immunology and Allergy
  • Infectious Diseases

Cite this

The association of antibodies against human T cell lymphotropic virus type I (HTLV-I) pX gene mutant products with HTLV-I-associated myelopathy/tropical spastic paraparesis. / Suzuki, Jun; Kira, Jun Ichi; Baba, Eishi; Nakamura, Minoru; Koyanagi, Yoshio; Nakamura, Tatsufumi; Kawano, Yuji; Yamasaki, Kenji; Shirabe, Susumu; Hatano, Naoya; Hayashi, Kenshi; Yamamoto, Naoki; Kobayashi, Takuro.

In: Journal of Infectious Diseases, Vol. 173, No. 5, 01.01.1996, p. 1115-1122.

Research output: Contribution to journalArticle

Suzuki, J, Kira, JI, Baba, E, Nakamura, M, Koyanagi, Y, Nakamura, T, Kawano, Y, Yamasaki, K, Shirabe, S, Hatano, N, Hayashi, K, Yamamoto, N & Kobayashi, T 1996, 'The association of antibodies against human T cell lymphotropic virus type I (HTLV-I) pX gene mutant products with HTLV-I-associated myelopathy/tropical spastic paraparesis', Journal of Infectious Diseases, vol. 173, no. 5, pp. 1115-1122. https://doi.org/10.1093/infdis/173.5.1115
Suzuki, Jun ; Kira, Jun Ichi ; Baba, Eishi ; Nakamura, Minoru ; Koyanagi, Yoshio ; Nakamura, Tatsufumi ; Kawano, Yuji ; Yamasaki, Kenji ; Shirabe, Susumu ; Hatano, Naoya ; Hayashi, Kenshi ; Yamamoto, Naoki ; Kobayashi, Takuro. / The association of antibodies against human T cell lymphotropic virus type I (HTLV-I) pX gene mutant products with HTLV-I-associated myelopathy/tropical spastic paraparesis. In: Journal of Infectious Diseases. 1996 ; Vol. 173, No. 5. pp. 1115-1122.
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