The association of antibodies against human T cell lymphotropic virus type I (HTLV-I) pX gene mutant products with HTLV-I-associated myelopathy/tropical spastic paraparesis

Jun Suzuki, Jun Ichi Kira, Eishi Baba, Minoru Nakamura, Yoshio Koyanagi, Tatsufumi Nakamura, Yuji Kawano, Kenji Yamasaki, Susumu Shirabe, Naoya Hatano, Kenshi Hayashi, Naoki Yamamoto, Takuro Kobayashi

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3 Citations (Scopus)

Abstract

Antibodies specific for the products of the human T cell lymphotropic virus type 1 (HTLV-I) pX frame-shift mutants were studied by ELISA. The serum IgG antibodies to the synthetic peptide corresponding to one nucleotide insertion at position 7784 were significantly more common in patients with HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) patients than in HTLV-I carriers who had neither HAM/TSP nor adult T cell leukemia (39% vs. 5%). The seropositivities to the other synthetic peptides, which corresponded to the one nucleotide deletion at position 7475 and the internal deletion of nt 7754-7819 and nt 7853-7936, were rare. A genetic study confirmed the presence of the responsible mutation of the pX gene in peripheral blood mononuclear cells and central nervous system tissue from HTLV-I-infected subjects with and without HAM/TSP. These results suggest that HTLV-I pX frame-shift mutants are expressed in vivo in HTLV-I carriers; they also induce antibodies, especially in those with HAM/TSP.

Original languageEnglish
Pages (from-to)1115-1122
Number of pages8
JournalJournal of Infectious Diseases
Volume173
Issue number5
DOIs
Publication statusPublished - Jan 1 1996
Externally publishedYes

ASJC Scopus subject areas

  • Immunology and Allergy
  • Infectious Diseases

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    Suzuki, J., Kira, J. I., Baba, E., Nakamura, M., Koyanagi, Y., Nakamura, T., Kawano, Y., Yamasaki, K., Shirabe, S., Hatano, N., Hayashi, K., Yamamoto, N., & Kobayashi, T. (1996). The association of antibodies against human T cell lymphotropic virus type I (HTLV-I) pX gene mutant products with HTLV-I-associated myelopathy/tropical spastic paraparesis. Journal of Infectious Diseases, 173(5), 1115-1122. https://doi.org/10.1093/infdis/173.5.1115