The antigen 85 complex vaccine against experimental Mycobacterium leprae infection in mice

Mariko Naito, Masanori Matsuoka, Naoya Ohara, Hiroko Nomaguchi, Takeshi Yamada

Research output: Contribution to journal › Article › peer-review

13 Citations (Scopus)

Abstract

The proteins in culture filtrate derived from Bacillus Calmette-Guerin (BCG) were examined for protection against infection by Mycobacterium leprae. Immunization with the major secreted proteins, antigen 85 complex (Ag 85) A, B and C, induced effective protective immunity against multiplication of M. leprae in the foot pads of mice. The most effective protection was observed when mice were immunized with Ag 85A. A single immunization with Ag 85 could induce antigen-specific interferon γ (IFNγ) synthesis and more effective protection than live BCG vaccine. This study demonstrates that Ag 85 is an important immunoprotective molecule against leprosy infection. Copyright (C) 1999 Elsevier Science Ltd.

Original languageEnglish
Pages (from-to)795-798
Number of pages4
JournalVaccine
Volume18
Issue number9-10
DOIs
Publication statusPublished - Dec 10 1999
Externally publishedYes

Keywords

  • Ag 85
  • Leprosy
  • Vaccine

ASJC Scopus subject areas

  • Molecular Medicine
  • Immunology and Microbiology(all)
  • veterinary(all)
  • Public Health, Environmental and Occupational Health
  • Infectious Diseases

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