The antigen 85 complex vaccine against experimental Mycobacterium leprae infection in mice

Mariko Naito; Masanori Matsuoka; Naoya Ohara; Hiroko Nomaguchi; Takeshi Yamada

doi:10.1016/S0264-410X(99)00327-8

The antigen 85 complex vaccine against experimental Mycobacterium leprae infection in mice

Mariko Naito, Masanori Matsuoka, Naoya Ohara, Hiroko Nomaguchi, Takeshi Yamada

Research output: Contribution to journal › Article

13 Citations (Scopus)

Abstract

The proteins in culture filtrate derived from Bacillus Calmette-Guerin (BCG) were examined for protection against infection by Mycobacterium leprae. Immunization with the major secreted proteins, antigen 85 complex (Ag 85) A, B and C, induced effective protective immunity against multiplication of M. leprae in the foot pads of mice. The most effective protection was observed when mice were immunized with Ag 85A. A single immunization with Ag 85 could induce antigen-specific interferon γ (IFNγ) synthesis and more effective protection than live BCG vaccine. This study demonstrates that Ag 85 is an important immunoprotective molecule against leprosy infection. Copyright (C) 1999 Elsevier Science Ltd.

Original language	English
Pages (from-to)	795-798
Number of pages	4
Journal	Vaccine
Volume	18
Issue number	9-10
DOIs	https://doi.org/10.1016/S0264-410X(99)00327-8
Publication status	Published - Dec 10 1999

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Keywords

Ag 85
Leprosy
Vaccine

ASJC Scopus subject areas

Molecular Medicine
Immunology and Microbiology(all)
veterinary(all)
Public Health, Environmental and Occupational Health
Infectious Diseases

Cite this

Naito, M., Matsuoka, M., Ohara, N., Nomaguchi, H., & Yamada, T. (1999). The antigen 85 complex vaccine against experimental Mycobacterium leprae infection in mice. Vaccine, 18(9-10), 795-798. https://doi.org/10.1016/S0264-410X(99)00327-8

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10.1016/S0264-410X(99)00327-8