Abstract
The proteins in culture filtrate derived from Bacillus Calmette-Guerin (BCG) were examined for protection against infection by Mycobacterium leprae. Immunization with the major secreted proteins, antigen 85 complex (Ag 85) A, B and C, induced effective protective immunity against multiplication of M. leprae in the foot pads of mice. The most effective protection was observed when mice were immunized with Ag 85A. A single immunization with Ag 85 could induce antigen-specific interferon γ (IFNγ) synthesis and more effective protection than live BCG vaccine. This study demonstrates that Ag 85 is an important immunoprotective molecule against leprosy infection. Copyright (C) 1999 Elsevier Science Ltd.
| Original language | English |
|---|---|
| Pages (from-to) | 795-798 |
| Number of pages | 4 |
| Journal | Vaccine |
| Volume | 18 |
| Issue number | 9-10 |
| DOIs | |
| Publication status | Published - Dec 10 1999 |
| Externally published | Yes |
Keywords
- Ag 85
- Leprosy
- Vaccine
ASJC Scopus subject areas
- Molecular Medicine
- Immunology and Microbiology(all)
- veterinary(all)
- Public Health, Environmental and Occupational Health
- Infectious Diseases
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Cite this
Naito, M., Matsuoka, M., Ohara, N., Nomaguchi, H., & Yamada, T. (1999). The antigen 85 complex vaccine against experimental Mycobacterium leprae infection in mice. Vaccine, 18(9-10), 795-798. https://doi.org/10.1016/S0264-410X(99)00327-8