Abstract
(Purpose) Some reports suggest that the high level expression of thymidine phosphorylase (TP), which is known as one of angiogenic factors, is related to high malignancy and also poor prognosis in the field of gastrointestinal cancer. So the authors investigated the expression of TP in bladder cancer. (Materials and methods) The expression of TP in cancer tissues and normal tissues, which were obtained during transurethral resection of the tumor of 66 patients with initial primary bladder cancer, was examined by enzyme-linked immunosorbent assay (ELISA). And relationship of the TP expression and clinicopathologic factors was investigated. (Results) The level of TP expression was significantly high in cancer tissues compared with normal tissues (P<0.0001). About the level of TP expression of cancer tissues, there was a significant difference between G1 and G3 in grade (P = 0.0099), Ta and T2 or greater (P = 0.0059), Ta, T1 and T2 or greater (P = 0.0157) in T stage, papillary and non-papillary in surface form (P = 0.0056), pedunculated and sessile in tumor shape (P = 0.0458), and 1 cm or under and 3 cm or greater in size (P = 0.0267). The level was higher in latter, respectively. About the level of TP expression of normal tissues, the level was significantly higher in the cases with sessile tumor than the cases with pedunculated tumor (P = 0.0078). (Conclusion) There is correlation between the level of TP expression of cancer tissues and their grade of malignancy, so we can expect that the level of TP expression of cancer tissues will be a prognostic factor. And what does it mean in the fact that the level of TP expression of normal tissues in patients with sessile tumor is higher? It should be clear after accumulation of the cases and collecting the episodes in the follow-up period.
| Original language | English |
|---|---|
| Pages (from-to) | 743-749 |
| Number of pages | 7 |
| Journal | Japanese Journal of Urology |
| Volume | 93 |
| Issue number | 7 |
| Publication status | Published - Nov 2002 |
| Externally published | Yes |
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Keywords
- Bladder cancer
- Thymidine phosphorylase
ASJC Scopus subject areas
- Urology
Cite this
The analysis of thymidine phosphorylase examined by ELISA in bladder cancer. / Saegusa, Michihisa; Takao, Akira; Manabe, Daisuke; Ichikawa, Takaharu; Aramaki, Kenji; Nakayama, Yasuki; Yamada, Daisuke.
In: Japanese Journal of Urology, Vol. 93, No. 7, 11.2002, p. 743-749.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - The analysis of thymidine phosphorylase examined by ELISA in bladder cancer
AU - Saegusa, Michihisa
AU - Takao, Akira
AU - Manabe, Daisuke
AU - Ichikawa, Takaharu
AU - Aramaki, Kenji
AU - Nakayama, Yasuki
AU - Yamada, Daisuke
PY - 2002/11
Y1 - 2002/11
N2 - (Purpose) Some reports suggest that the high level expression of thymidine phosphorylase (TP), which is known as one of angiogenic factors, is related to high malignancy and also poor prognosis in the field of gastrointestinal cancer. So the authors investigated the expression of TP in bladder cancer. (Materials and methods) The expression of TP in cancer tissues and normal tissues, which were obtained during transurethral resection of the tumor of 66 patients with initial primary bladder cancer, was examined by enzyme-linked immunosorbent assay (ELISA). And relationship of the TP expression and clinicopathologic factors was investigated. (Results) The level of TP expression was significantly high in cancer tissues compared with normal tissues (P<0.0001). About the level of TP expression of cancer tissues, there was a significant difference between G1 and G3 in grade (P = 0.0099), Ta and T2 or greater (P = 0.0059), Ta, T1 and T2 or greater (P = 0.0157) in T stage, papillary and non-papillary in surface form (P = 0.0056), pedunculated and sessile in tumor shape (P = 0.0458), and 1 cm or under and 3 cm or greater in size (P = 0.0267). The level was higher in latter, respectively. About the level of TP expression of normal tissues, the level was significantly higher in the cases with sessile tumor than the cases with pedunculated tumor (P = 0.0078). (Conclusion) There is correlation between the level of TP expression of cancer tissues and their grade of malignancy, so we can expect that the level of TP expression of cancer tissues will be a prognostic factor. And what does it mean in the fact that the level of TP expression of normal tissues in patients with sessile tumor is higher? It should be clear after accumulation of the cases and collecting the episodes in the follow-up period.
AB - (Purpose) Some reports suggest that the high level expression of thymidine phosphorylase (TP), which is known as one of angiogenic factors, is related to high malignancy and also poor prognosis in the field of gastrointestinal cancer. So the authors investigated the expression of TP in bladder cancer. (Materials and methods) The expression of TP in cancer tissues and normal tissues, which were obtained during transurethral resection of the tumor of 66 patients with initial primary bladder cancer, was examined by enzyme-linked immunosorbent assay (ELISA). And relationship of the TP expression and clinicopathologic factors was investigated. (Results) The level of TP expression was significantly high in cancer tissues compared with normal tissues (P<0.0001). About the level of TP expression of cancer tissues, there was a significant difference between G1 and G3 in grade (P = 0.0099), Ta and T2 or greater (P = 0.0059), Ta, T1 and T2 or greater (P = 0.0157) in T stage, papillary and non-papillary in surface form (P = 0.0056), pedunculated and sessile in tumor shape (P = 0.0458), and 1 cm or under and 3 cm or greater in size (P = 0.0267). The level was higher in latter, respectively. About the level of TP expression of normal tissues, the level was significantly higher in the cases with sessile tumor than the cases with pedunculated tumor (P = 0.0078). (Conclusion) There is correlation between the level of TP expression of cancer tissues and their grade of malignancy, so we can expect that the level of TP expression of cancer tissues will be a prognostic factor. And what does it mean in the fact that the level of TP expression of normal tissues in patients with sessile tumor is higher? It should be clear after accumulation of the cases and collecting the episodes in the follow-up period.
KW - Bladder cancer
KW - Thymidine phosphorylase
UR - http://www.scopus.com/inward/record.url?scp=0036857026&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0036857026&partnerID=8YFLogxK
M3 - Article
C2 - 12494519
AN - SCOPUS:0036857026
VL - 93
SP - 743
EP - 749
JO - Japanese Journal of Urology
JF - Japanese Journal of Urology
SN - 0021-5287
IS - 7
ER -