The analysis of the usefulness of laparoscopic microwave coagulation therapy for hepatocellular carcinoma in patients with poor hepatic reserve by serial measurements of IL-6, cytokine antagonists, and C-reactive protein

H. Sadamori, T. Yagi, Y. Kanaoka, Y. Morimoto, M. Inagaki, T. Ishikawa, H. Matsukawa, H. Matsuda, H. Iwagaki, N. Tanaka

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Background: Little is known about the effectiveness of laparoscopic microwave coagulation therapy (L-MCT) for hepatocellular carcinoma (HCC) in patients with liver cirrhosis and poor hepatic reserve. Here, we analyzed the usefulness of laparoscopic MCT by comparing the serum levels of IL-6, cytokine antagonists, and creactive protein (CRP) following L-MCT with those following MCT with the open method (O-MCT). Methods: Sixteen patients with hepatocellular carcinoma (HCC) were separated into L-MCT and O-MCT groups according to ICGR15 (ICGR15 30% <:L-MCT, 30% >:O-MCT). Nine patients with poorer hepatic reserve received L-MCT, while seven patients with relatively good hepatic reserve received O-MCT. Serum levels of cytokine antagonists (interleukin-6, IL-6; interleukin-1 receptor antagonist, IL-1ra; soluble tumor necrosis factor receptor type I, sTNF-R55) and C-reactive protein (CRP) were simultaneously measured on serial postoperative days (POD) by immunoassay. Results: Postoperative serum levels of IL-6, IL-1ra, and CRP were significantly elevated on POD-1 and returned to the preoperative levels on POD-7 in both L-MCT and O-MCT groups. In contrast, no significant elevation of sTNF-R55 was found during the period in both groups. In addition, no statistical differences were found in the levels of IL-6, IL-1ra, sTNF-R, and CRP between the groups, except that the level of IL-6 on POD-1 in L-MCT group was significantly lower than that in the O-MCT group. Conclusion: These results suggested that the surgical stress by L-MCT in patients with poorer hepatic reserve were almost equal to that by O-MCT in patients with relatively good hepatic reserve, indicating the usefulness of L-MCT for HCC patients with poorer hepatic reserve. We recommend the laparoscopic approach for future patients with the criterion that ICGR15 is over 30%.

Original languageEnglish
Pages (from-to)510-514
Number of pages5
JournalSurgical Endoscopy and Other Interventional Techniques
Volume17
Issue number3
DOIs
Publication statusPublished - Mar 1 2003

Keywords

  • Hepatic reserve
  • Hepatocellular carcinoma
  • IL-1ra
  • IL-6
  • Laparoscopic microwave coagulation therapy
  • STNF-R

ASJC Scopus subject areas

  • Surgery

Fingerprint Dive into the research topics of 'The analysis of the usefulness of laparoscopic microwave coagulation therapy for hepatocellular carcinoma in patients with poor hepatic reserve by serial measurements of IL-6, cytokine antagonists, and C-reactive protein'. Together they form a unique fingerprint.

  • Cite this