The activity of dihydropyrimidine dehydrogenase from rat liver was not affected by any of five 5-hydroxytryptamine antagonists

Tomonori Tateishi, Hironori Nakura, Minoru Watanabe, Masami Tanaka, Toshio Kumai, Shinichi Kobayashi

Research output: Contribution to journalArticle

Abstract

We estimate the influence of five 5-hydroxytryptamine receptor (5-HT3) antagonists on the activity of dihydropyrimidine dehydrogenase (DPDase), the rate-limiting enzyme in 5-fluorouracil (5FU) metabolism. The activity of DPDase from the rat liver was compared in the cytosol mixture of 5FU incubated with or without each of five 5-HT3 antagonists. DPDase activity was not altered in the presence of any 5-HT3 antagonist studied here. It may be inferred from these results that the any 5-HT3 receptor antagonist examined in this study has little or no effect on fluorouracil catabolism.

Original languageEnglish
Pages (from-to)1-5
Number of pages5
JournalCancer Letters
Volume108
Issue number1
DOIs
Publication statusPublished - Nov 12 1996
Externally publishedYes

Keywords

  • 5-fluorouracil
  • 5-hyroxytrypamine antagonists
  • Dihydropyrimide dehydrogenase
  • Rat liver cytosol

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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