The activity of dihydropyrimidine dehydrogenase from rat liver was not affected by any of five 5-hydroxytryptamine antagonists

Tomonori Tateishi, Hironori Nakura, Minoru Watanabe, Masami Tanaka, Toshio Kumai, Shinichi Kobayashi

Research output: Contribution to journalArticle

Abstract

We estimate the influence of five 5-hydroxytryptamine receptor (5-HT3) antagonists on the activity of dihydropyrimidine dehydrogenase (DPDase), the rate-limiting enzyme in 5-fluorouracil (5FU) metabolism. The activity of DPDase from the rat liver was compared in the cytosol mixture of 5FU incubated with or without each of five 5-HT3 antagonists. DPDase activity was not altered in the presence of any 5-HT3 antagonist studied here. It may be inferred from these results that the any 5-HT3 receptor antagonist examined in this study has little or no effect on fluorouracil catabolism.

Original languageEnglish
Pages (from-to)1-5
Number of pages5
JournalCancer Letters
Volume108
Issue number1
DOIs
Publication statusPublished - Nov 12 1996
Externally publishedYes

Fingerprint

Dihydrouracil Dehydrogenase (NADP)
Serotonin 5-HT3 Receptor Antagonists
Serotonin Antagonists
Fluorouracil
Liver
Receptors, Serotonin, 5-HT3
Cytosol
Enzymes

Keywords

  • 5-fluorouracil
  • 5-hyroxytrypamine antagonists
  • Dihydropyrimide dehydrogenase
  • Rat liver cytosol

ASJC Scopus subject areas

  • Cancer Research
  • Molecular Biology
  • Oncology

Cite this

The activity of dihydropyrimidine dehydrogenase from rat liver was not affected by any of five 5-hydroxytryptamine antagonists. / Tateishi, Tomonori; Nakura, Hironori; Watanabe, Minoru; Tanaka, Masami; Kumai, Toshio; Kobayashi, Shinichi.

In: Cancer Letters, Vol. 108, No. 1, 12.11.1996, p. 1-5.

Research output: Contribution to journalArticle

Tateishi, Tomonori ; Nakura, Hironori ; Watanabe, Minoru ; Tanaka, Masami ; Kumai, Toshio ; Kobayashi, Shinichi. / The activity of dihydropyrimidine dehydrogenase from rat liver was not affected by any of five 5-hydroxytryptamine antagonists. In: Cancer Letters. 1996 ; Vol. 108, No. 1. pp. 1-5.
@article{e1745c67c2ef4674b740173ad80a0f80,
title = "The activity of dihydropyrimidine dehydrogenase from rat liver was not affected by any of five 5-hydroxytryptamine antagonists",
abstract = "We estimate the influence of five 5-hydroxytryptamine receptor (5-HT3) antagonists on the activity of dihydropyrimidine dehydrogenase (DPDase), the rate-limiting enzyme in 5-fluorouracil (5FU) metabolism. The activity of DPDase from the rat liver was compared in the cytosol mixture of 5FU incubated with or without each of five 5-HT3 antagonists. DPDase activity was not altered in the presence of any 5-HT3 antagonist studied here. It may be inferred from these results that the any 5-HT3 receptor antagonist examined in this study has little or no effect on fluorouracil catabolism.",
keywords = "5-fluorouracil, 5-hyroxytrypamine antagonists, Dihydropyrimide dehydrogenase, Rat liver cytosol",
author = "Tomonori Tateishi and Hironori Nakura and Minoru Watanabe and Masami Tanaka and Toshio Kumai and Shinichi Kobayashi",
year = "1996",
month = "11",
day = "12",
doi = "10.1016/S0304-3835(96)04361-3",
language = "English",
volume = "108",
pages = "1--5",
journal = "Cancer Letters",
issn = "0304-3835",
publisher = "Elsevier Ireland Ltd",
number = "1",

}

TY - JOUR

T1 - The activity of dihydropyrimidine dehydrogenase from rat liver was not affected by any of five 5-hydroxytryptamine antagonists

AU - Tateishi, Tomonori

AU - Nakura, Hironori

AU - Watanabe, Minoru

AU - Tanaka, Masami

AU - Kumai, Toshio

AU - Kobayashi, Shinichi

PY - 1996/11/12

Y1 - 1996/11/12

N2 - We estimate the influence of five 5-hydroxytryptamine receptor (5-HT3) antagonists on the activity of dihydropyrimidine dehydrogenase (DPDase), the rate-limiting enzyme in 5-fluorouracil (5FU) metabolism. The activity of DPDase from the rat liver was compared in the cytosol mixture of 5FU incubated with or without each of five 5-HT3 antagonists. DPDase activity was not altered in the presence of any 5-HT3 antagonist studied here. It may be inferred from these results that the any 5-HT3 receptor antagonist examined in this study has little or no effect on fluorouracil catabolism.

AB - We estimate the influence of five 5-hydroxytryptamine receptor (5-HT3) antagonists on the activity of dihydropyrimidine dehydrogenase (DPDase), the rate-limiting enzyme in 5-fluorouracil (5FU) metabolism. The activity of DPDase from the rat liver was compared in the cytosol mixture of 5FU incubated with or without each of five 5-HT3 antagonists. DPDase activity was not altered in the presence of any 5-HT3 antagonist studied here. It may be inferred from these results that the any 5-HT3 receptor antagonist examined in this study has little or no effect on fluorouracil catabolism.

KW - 5-fluorouracil

KW - 5-hyroxytrypamine antagonists

KW - Dihydropyrimide dehydrogenase

KW - Rat liver cytosol

UR - http://www.scopus.com/inward/record.url?scp=0030581619&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0030581619&partnerID=8YFLogxK

U2 - 10.1016/S0304-3835(96)04361-3

DO - 10.1016/S0304-3835(96)04361-3

M3 - Article

C2 - 8950202

AN - SCOPUS:0030581619

VL - 108

SP - 1

EP - 5

JO - Cancer Letters

JF - Cancer Letters

SN - 0304-3835

IS - 1

ER -