The activities of cytokines are pleiotropic and interdependent. Plenary lecture, Eight European Immunology Meeting, Zagreb, Yugoslavia, September 1987

Joost J. Oppenheim; Kouji Matsushima; Teizo Yoshimura; Edward J. Leonard

doi:10.1016/0165-2478(87)90145-3

The activities of cytokines are pleiotropic and interdependent. Plenary lecture, Eight European Immunology Meeting, Zagreb, Yugoslavia, September 1987

Joost J. Oppenheim, Kouji Matsushima, Teizo Yoshimura, Edward J. Leonard

Research output: Contribution to journal › Article › peer-review

16 Citations (Scopus)

Abstract

Many cytokines with multiple effects on the growth and functions of a wide variety of target cells have been discovered. Consequently, cytokines may exhibit considerable overlap in their biological effects on lymphoid, myeloid and connective tissue target cells. Even biologically distinct cytokines may have similar effects by initiating the production of a cascade of identical cytokines or of one another. The benefits of this apparent redundancy and interdependence of these activities remain to be established. Our information concerning cytokines is still far from complete, as illustrated by the recent characterization of a novel chemotactic cytokine and identification of a family of related mediators.

Original language	English
Pages (from-to)	179-183
Number of pages	5
Journal	Immunology Letters
Volume	16
Issue number	3-4
DOIs	https://doi.org/10.1016/0165-2478(87)90145-3
Publication status	Published - Dec 1987
Externally published	Yes

Keywords

Chemotactic factor
Cytokines
Interleukin 1
Lymphocyte
Meyloid cell

ASJC Scopus subject areas

Immunology and Allergy
Immunology

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abstract = "Many cytokines with multiple effects on the growth and functions of a wide variety of target cells have been discovered. Consequently, cytokines may exhibit considerable overlap in their biological effects on lymphoid, myeloid and connective tissue target cells. Even biologically distinct cytokines may have similar effects by initiating the production of a cascade of identical cytokines or of one another. The benefits of this apparent redundancy and interdependence of these activities remain to be established. Our information concerning cytokines is still far from complete, as illustrated by the recent characterization of a novel chemotactic cytokine and identification of a family of related mediators.",

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AU - Matsushima, Kouji

AU - Yoshimura, Teizo

AU - Leonard, Edward J.

PY - 1987/12

Y1 - 1987/12

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AB - Many cytokines with multiple effects on the growth and functions of a wide variety of target cells have been discovered. Consequently, cytokines may exhibit considerable overlap in their biological effects on lymphoid, myeloid and connective tissue target cells. Even biologically distinct cytokines may have similar effects by initiating the production of a cascade of identical cytokines or of one another. The benefits of this apparent redundancy and interdependence of these activities remain to be established. Our information concerning cytokines is still far from complete, as illustrated by the recent characterization of a novel chemotactic cytokine and identification of a family of related mediators.

KW - Chemotactic factor

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KW - Interleukin 1

KW - Lymphocyte

KW - Meyloid cell

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The activities of cytokines are pleiotropic and interdependent. Plenary lecture, Eight European Immunology Meeting, Zagreb, Yugoslavia, September 1987

Abstract

Keywords

ASJC Scopus subject areas

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