The activities of cytokines are pleiotropic and interdependent. Plenary lecture, Eight European Immunology Meeting, Zagreb, Yugoslavia, September 1987

Joost J. Oppenheim, Kouji Matsushima, Teizo Yoshimura, Edward J. Leonard

Research output: Contribution to journalArticlepeer-review

16 Citations (Scopus)

Abstract

Many cytokines with multiple effects on the growth and functions of a wide variety of target cells have been discovered. Consequently, cytokines may exhibit considerable overlap in their biological effects on lymphoid, myeloid and connective tissue target cells. Even biologically distinct cytokines may have similar effects by initiating the production of a cascade of identical cytokines or of one another. The benefits of this apparent redundancy and interdependence of these activities remain to be established. Our information concerning cytokines is still far from complete, as illustrated by the recent characterization of a novel chemotactic cytokine and identification of a family of related mediators.

Original languageEnglish
Pages (from-to)179-183
Number of pages5
JournalImmunology Letters
Volume16
Issue number3-4
DOIs
Publication statusPublished - Dec 1987
Externally publishedYes

Keywords

  • Chemotactic factor
  • Cytokines
  • Interleukin 1
  • Lymphocyte
  • Meyloid cell

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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