The ability of transplanted bone marrow-derived cells to differentiate into parenchymal cells of salivary glands

Yao Wei Yuan, Ryo Tamamura, Lei Lei, Naoki Katase, Gulsan Ara Sathi, Satoshi Ito, Hidetsugu Tsujigiwa, Hitoshi Nagatsuka

Research output: Contribution to journalArticle

3 Citations (Scopus)


Salivary glands are important exocrine glands for oral health and initial digestion. Salivary gland dysfunction resulting from irreversible glandular damage usually leads to poor life quality in patients. Recent investigations showed that bone marrow-derived cells (BMDCs) could be grafted into non-hematopoietic cells in multiple tissues. In this study, BMDCs from green fluorescent protein (GFP) mice were transplanted into irradiated C57BL/6 mice to assess the ability of BMDCs to differentiate into parenchymal cells of salivary glands by immunohistochemistry and double fluorescent staining. The data revealed that a population of GFP positive cells showed the characteristics of acinar cells, ductal cells and myoepithelial cells in parotid and submandibular glands, and that some of BMDCs presented amylase expression. These results showed that BMDCs have the ability to differentiate into parenchymal cells of salivary glands with certain glandular cell functions. Such plasticity of BMDCs can be the first step for salivary gland regeneration by stem cells and tissue engineering therapy.

Original languageEnglish
Pages (from-to)433-438
Number of pages6
JournalJournal of Hard Tissue Biology
Issue number4
Publication statusPublished - 2013



  • Bone marrow-derived cells
  • Differentiation
  • Green fluorescent protein
  • Parenchymal cells
  • Salivary gland

ASJC Scopus subject areas

  • Biochemistry
  • Cell Biology
  • Biomaterials
  • Medicine (miscellaneous)
  • Orthopedics and Sports Medicine
  • Dentistry(all)

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