The 5-HT1A receptor full agonist, 8-OH-DPAT inhibits ACTH-induced 5-HT2A receptor hyperfunction in rats: Involvement of 5-HT1A receptors in the DOI-induced wet-dog shakes in ACTH-treated rats

Yoshihisa Kitamura; Kouhei Kitagawa; Yoshika Fujitani; Kazuhiko Shibata; Hiroaki Araki; Toshiaki Sendou; Yutaka Gomita

doi:10.1248/bpb.30.117

The 5-HT_1A receptor full agonist, 8-OH-DPAT inhibits ACTH-induced 5-HT_2A receptor hyperfunction in rats: Involvement of 5-HT_1A receptors in the DOI-induced wet-dog shakes in ACTH-treated rats

Yoshihisa Kitamura, Kouhei Kitagawa, Yoshika Fujitani, Kazuhiko Shibata, Hiroaki Araki, Toshiaki Sendou, Yutaka Gomita

University Hospital

Research output: Contribution to journal › Article › peer-review

12 Citations (Scopus)

Abstract

We examined the influence of 8-hydroxy-2-di-n-propylamino tetralin (8-OH-DPAT), a serotonin 1A (5-HT_1A) receptor full agonist, on the wet-dog shake response induced by the (±)-1-(2,5-dimethoxy-4-iodophenyl)- 2-aminopropane (DOI), a 5-HT_2A receptor agonist, in adrenocorticotropic hormone (ACTH)-treated rats. Chronic ACTH (100 μg/rat, s.c.) treatment for 14 d increased the wet-dog shake response induced DOI. The 8-OH-DPAT inhibited the wet-dog shake response induced by DOI in rats with ACTH for 14 d. On the other hand, the 8-OH-DPAT-induced hypothermia and flat body posture were inhibited when ACTH was administered for 14 d. These findings suggest that chronic treatment with ACTH decreased the sensitivity of the 5-HT_1A receptor system; however, the inhibitory effects from the 5-HT_1A receptors to the 5-HT_2A receptor system is not inhibited in ACTH-treated rats.

Original language	English
Pages (from-to)	117-120
Number of pages	4
Journal	Biological and Pharmaceutical Bulletin
Volume	30
Issue number	1
DOIs	https://doi.org/10.1248/bpb.30.117
Publication status	Published - 2007

Keywords

(±)-1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (DOI)
5-HTreceptor
5-HTreceptor
8-hydroxy-2-di-n-propylamino tetralin (8-OH-DPAT)
Wet-dog shake

ASJC Scopus subject areas

Pharmacology
Pharmaceutical Science

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Kitamura, Y., Kitagawa, K., Fujitani, Y., Shibata, K., Araki, H., Sendou, T., & Gomita, Y. (2007). The 5-HT_1A receptor full agonist, 8-OH-DPAT inhibits ACTH-induced 5-HT_2A receptor hyperfunction in rats: Involvement of 5-HT_1A receptors in the DOI-induced wet-dog shakes in ACTH-treated rats. Biological and Pharmaceutical Bulletin, 30(1), 117-120. https://doi.org/10.1248/bpb.30.117

The 5-HT_1A receptor full agonist, 8-OH-DPAT inhibits ACTH-induced 5-HT_2A receptor hyperfunction in rats : Involvement of 5-HT_1A receptors in the DOI-induced wet-dog shakes in ACTH-treated rats. / Kitamura, Yoshihisa; Kitagawa, Kouhei; Fujitani, Yoshika; Shibata, Kazuhiko; Araki, Hiroaki; Sendou, Toshiaki; Gomita, Yutaka.

In: Biological and Pharmaceutical Bulletin, Vol. 30, No. 1, 2007, p. 117-120.

Research output: Contribution to journal › Article › peer-review

Kitamura, Y, Kitagawa, K, Fujitani, Y, Shibata, K, Araki, H, Sendou, T & Gomita, Y 2007, 'The 5-HT_1A receptor full agonist, 8-OH-DPAT inhibits ACTH-induced 5-HT_2A receptor hyperfunction in rats: Involvement of 5-HT_1A receptors in the DOI-induced wet-dog shakes in ACTH-treated rats', Biological and Pharmaceutical Bulletin, vol. 30, no. 1, pp. 117-120. https://doi.org/10.1248/bpb.30.117

Kitamura, Yoshihisa ; Kitagawa, Kouhei ; Fujitani, Yoshika ; Shibata, Kazuhiko ; Araki, Hiroaki ; Sendou, Toshiaki ; Gomita, Yutaka. / The 5-HT_1A receptor full agonist, 8-OH-DPAT inhibits ACTH-induced 5-HT_2A receptor hyperfunction in rats : Involvement of 5-HT_1A receptors in the DOI-induced wet-dog shakes in ACTH-treated rats. In: Biological and Pharmaceutical Bulletin. 2007 ; Vol. 30, No. 1. pp. 117-120.

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abstract = "We examined the influence of 8-hydroxy-2-di-n-propylamino tetralin (8-OH-DPAT), a serotonin 1A (5-HT1A) receptor full agonist, on the wet-dog shake response induced by the (±)-1-(2,5-dimethoxy-4-iodophenyl)- 2-aminopropane (DOI), a 5-HT2A receptor agonist, in adrenocorticotropic hormone (ACTH)-treated rats. Chronic ACTH (100 μg/rat, s.c.) treatment for 14 d increased the wet-dog shake response induced DOI. The 8-OH-DPAT inhibited the wet-dog shake response induced by DOI in rats with ACTH for 14 d. On the other hand, the 8-OH-DPAT-induced hypothermia and flat body posture were inhibited when ACTH was administered for 14 d. These findings suggest that chronic treatment with ACTH decreased the sensitivity of the 5-HT1A receptor system; however, the inhibitory effects from the 5-HT1A receptors to the 5-HT2A receptor system is not inhibited in ACTH-treated rats.",

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