The 5-HT1A receptor full agonist, 8-OH-DPAT inhibits ACTH-induced 5-HT2A receptor hyperfunction in rats: Involvement of 5-HT1A receptors in the DOI-induced wet-dog shakes in ACTH-treated rats

Yoshihisa Kitamura, Kouhei Kitagawa, Yoshika Fujitani, Kazuhiko Shibata, Hiroaki Araki, Toshiaki Sendou, Yutaka Gomita

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

We examined the influence of 8-hydroxy-2-di-n-propylamino tetralin (8-OH-DPAT), a serotonin 1A (5-HT1A) receptor full agonist, on the wet-dog shake response induced by the (±)-1-(2,5-dimethoxy-4-iodophenyl)- 2-aminopropane (DOI), a 5-HT2A receptor agonist, in adrenocorticotropic hormone (ACTH)-treated rats. Chronic ACTH (100 μg/rat, s.c.) treatment for 14 d increased the wet-dog shake response induced DOI. The 8-OH-DPAT inhibited the wet-dog shake response induced by DOI in rats with ACTH for 14 d. On the other hand, the 8-OH-DPAT-induced hypothermia and flat body posture were inhibited when ACTH was administered for 14 d. These findings suggest that chronic treatment with ACTH decreased the sensitivity of the 5-HT1A receptor system; however, the inhibitory effects from the 5-HT1A receptors to the 5-HT2A receptor system is not inhibited in ACTH-treated rats.

Original languageEnglish
Pages (from-to)117-120
Number of pages4
JournalBiological and Pharmaceutical Bulletin
Volume30
Issue number1
DOIs
Publication statusPublished - Jan 15 2007

Keywords

  • (±)-1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (DOI)
  • 5-HTreceptor
  • 5-HTreceptor
  • 8-hydroxy-2-di-n-propylamino tetralin (8-OH-DPAT)
  • Wet-dog shake

ASJC Scopus subject areas

  • Pharmacology
  • Pharmaceutical Science

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