TY - JOUR
T1 - The 5-HT1A receptor full agonist, 8-OH-DPAT inhibits ACTH-induced 5-HT2A receptor hyperfunction in rats
T2 - Involvement of 5-HT1A receptors in the DOI-induced wet-dog shakes in ACTH-treated rats
AU - Kitamura, Yoshihisa
AU - Kitagawa, Kouhei
AU - Fujitani, Yoshika
AU - Shibata, Kazuhiko
AU - Araki, Hiroaki
AU - Sendou, Toshiaki
AU - Gomita, Yutaka
PY - 2007
Y1 - 2007
N2 - We examined the influence of 8-hydroxy-2-di-n-propylamino tetralin (8-OH-DPAT), a serotonin 1A (5-HT1A) receptor full agonist, on the wet-dog shake response induced by the (±)-1-(2,5-dimethoxy-4-iodophenyl)- 2-aminopropane (DOI), a 5-HT2A receptor agonist, in adrenocorticotropic hormone (ACTH)-treated rats. Chronic ACTH (100 μg/rat, s.c.) treatment for 14 d increased the wet-dog shake response induced DOI. The 8-OH-DPAT inhibited the wet-dog shake response induced by DOI in rats with ACTH for 14 d. On the other hand, the 8-OH-DPAT-induced hypothermia and flat body posture were inhibited when ACTH was administered for 14 d. These findings suggest that chronic treatment with ACTH decreased the sensitivity of the 5-HT1A receptor system; however, the inhibitory effects from the 5-HT1A receptors to the 5-HT2A receptor system is not inhibited in ACTH-treated rats.
AB - We examined the influence of 8-hydroxy-2-di-n-propylamino tetralin (8-OH-DPAT), a serotonin 1A (5-HT1A) receptor full agonist, on the wet-dog shake response induced by the (±)-1-(2,5-dimethoxy-4-iodophenyl)- 2-aminopropane (DOI), a 5-HT2A receptor agonist, in adrenocorticotropic hormone (ACTH)-treated rats. Chronic ACTH (100 μg/rat, s.c.) treatment for 14 d increased the wet-dog shake response induced DOI. The 8-OH-DPAT inhibited the wet-dog shake response induced by DOI in rats with ACTH for 14 d. On the other hand, the 8-OH-DPAT-induced hypothermia and flat body posture were inhibited when ACTH was administered for 14 d. These findings suggest that chronic treatment with ACTH decreased the sensitivity of the 5-HT1A receptor system; however, the inhibitory effects from the 5-HT1A receptors to the 5-HT2A receptor system is not inhibited in ACTH-treated rats.
KW - (±)-1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (DOI)
KW - 5-HTreceptor
KW - 5-HTreceptor
KW - 8-hydroxy-2-di-n-propylamino tetralin (8-OH-DPAT)
KW - Wet-dog shake
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UR - http://www.scopus.com/inward/citedby.url?scp=33846119311&partnerID=8YFLogxK
U2 - 10.1248/bpb.30.117
DO - 10.1248/bpb.30.117
M3 - Article
C2 - 17202670
AN - SCOPUS:33846119311
VL - 30
SP - 117
EP - 120
JO - Biological and Pharmaceutical Bulletin
JF - Biological and Pharmaceutical Bulletin
SN - 0918-6158
IS - 1
ER -