The 1999 domestic state of development of anti-asthma

K. Onodera, N. Sogawa, C. Sogawa, H. Furuta

Research output: Contribution to journalArticle

Abstract

According to the "Guideline for Diagnosis and Treatment of Asthma" established by the Japanese Society of Allergy in 1998, inhaled adrenergic β2 agonists and inhaled corticosteroids are recommended for treatment of asthma. Thereafter, the development of new drugs for the treatment of asthma has begun changing. The concepts upon which the development of investigational drugs for asthma are based include improvements of drug delivery systems (ease of use, long-acting preparations, fewer side-effects), device design and appropriate auxiliary instrumentation. Moreover, chronic asthma has come to be recognized as an inflammatory disease of airway mucosa. At present, various antiallergic compounds such as tachykinin, leucotrien, PAF antagonists and others are under investigation thanks to the identification of new chemical mediators of airway inflammation and studies have progressed to the synthesis and manufacturing of new pharmaceuticals with antagonistic action. Thus, this review classified and introduced various new investigational anti-asthma and further describes the structure-activity relationships of β2 agonists and inhaled corticosteroids.

Original languageEnglish
Pages (from-to)385-394
Number of pages10
JournalFolia Pharmacologica Japonica
Volume116
Issue number6
Publication statusPublished - Dec 1 2000

Keywords

  • Anti-asthma
  • Asthma
  • Inhaled adrenergic β agonists
  • Inhaled corticosteroids
  • Investigational drugs for asthma

ASJC Scopus subject areas

  • Pharmacology

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    Onodera, K., Sogawa, N., Sogawa, C., & Furuta, H. (2000). The 1999 domestic state of development of anti-asthma. Folia Pharmacologica Japonica, 116(6), 385-394.