Thallium-201 scintigraphy is an effective diagnostic modality to distinguish malignant from benign soft-tissue tumors

Naoaki Kawakami, Toshiyuki Kunisada, Shuhei Sato, Yuki Morimoto, Masato Tanaka, Tsuyoshi Sasaki, Shinsuke Sugihara, Hiroyuki Yanai, Susumu Kanazawa, Toshihumi Ozaki

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Background: The aim of this study is to evaluate whether thallium-201 (201-Tl) scintigraphy can differentiate malignant from benign soft-tissue tumors. Methods: Between April 1995 and December 2005, 192 patients with soft-tissue tumors (85 malignant and 107 benign) underwent 201-Tl scintigraphy before treatment. Isotope uptake was used as a proxy for tumor-to-background ratio (TBR). The accuracy of TBR on early and delayed imaging was evaluated using the Mann-Whitney U and χ 2 tests. Results: There was a statistically significant difference in mean TBR on early and delayed imaging of malignant and benign soft-tissue tumors (124% ± 109% vs. 22% ± 42%, and 82% ± 83% vs. 12% ± 25%, P <0.0001). A TBR cutoff of 20% indicated the probability of malignancy on early and delayed imaging (82% sensitivity and 77% specificity; 82% sensitivity and 84% specificity, P <0.0001). Well-differentiated liposarcomas showed low isotope accumulation, while pigmented villonodular synovitis and giant cell tumors of the tendon sheath showed high isotope accumulation. Conclusions: Thallium-201 scintigraphy can distinguish malignant from benign tumors with relatively high accuracy. With the exception of low grade liposarcomas and locally aggressive benign tumors, 201-Tl scintigraphy may be an effective diagnostic modality to differentiate malignant from benign soft-tissue tumors.

Original languageEnglish
Pages (from-to)982-986
Number of pages5
JournalClinical Nuclear Medicine
Volume36
Issue number11
DOIs
Publication statusPublished - Nov 2011

Fingerprint

Thallium
Radionuclide Imaging
Neoplasms
Isotopes
Liposarcoma
Pigmented Villonodular Synovitis
Sensitivity and Specificity
Proxy
Nonparametric Statistics

Keywords

  • sarcoma
  • scintigraphy
  • soft-tissue
  • thallium-201
  • tumor

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Cite this

Thallium-201 scintigraphy is an effective diagnostic modality to distinguish malignant from benign soft-tissue tumors. / Kawakami, Naoaki; Kunisada, Toshiyuki; Sato, Shuhei; Morimoto, Yuki; Tanaka, Masato; Sasaki, Tsuyoshi; Sugihara, Shinsuke; Yanai, Hiroyuki; Kanazawa, Susumu; Ozaki, Toshihumi.

In: Clinical Nuclear Medicine, Vol. 36, No. 11, 11.2011, p. 982-986.

Research output: Contribution to journalArticle

Kawakami, Naoaki ; Kunisada, Toshiyuki ; Sato, Shuhei ; Morimoto, Yuki ; Tanaka, Masato ; Sasaki, Tsuyoshi ; Sugihara, Shinsuke ; Yanai, Hiroyuki ; Kanazawa, Susumu ; Ozaki, Toshihumi. / Thallium-201 scintigraphy is an effective diagnostic modality to distinguish malignant from benign soft-tissue tumors. In: Clinical Nuclear Medicine. 2011 ; Vol. 36, No. 11. pp. 982-986.
@article{0754292fc02b4bc189296fa6e3a17820,
title = "Thallium-201 scintigraphy is an effective diagnostic modality to distinguish malignant from benign soft-tissue tumors",
abstract = "Background: The aim of this study is to evaluate whether thallium-201 (201-Tl) scintigraphy can differentiate malignant from benign soft-tissue tumors. Methods: Between April 1995 and December 2005, 192 patients with soft-tissue tumors (85 malignant and 107 benign) underwent 201-Tl scintigraphy before treatment. Isotope uptake was used as a proxy for tumor-to-background ratio (TBR). The accuracy of TBR on early and delayed imaging was evaluated using the Mann-Whitney U and χ 2 tests. Results: There was a statistically significant difference in mean TBR on early and delayed imaging of malignant and benign soft-tissue tumors (124{\%} ± 109{\%} vs. 22{\%} ± 42{\%}, and 82{\%} ± 83{\%} vs. 12{\%} ± 25{\%}, P <0.0001). A TBR cutoff of 20{\%} indicated the probability of malignancy on early and delayed imaging (82{\%} sensitivity and 77{\%} specificity; 82{\%} sensitivity and 84{\%} specificity, P <0.0001). Well-differentiated liposarcomas showed low isotope accumulation, while pigmented villonodular synovitis and giant cell tumors of the tendon sheath showed high isotope accumulation. Conclusions: Thallium-201 scintigraphy can distinguish malignant from benign tumors with relatively high accuracy. With the exception of low grade liposarcomas and locally aggressive benign tumors, 201-Tl scintigraphy may be an effective diagnostic modality to differentiate malignant from benign soft-tissue tumors.",
keywords = "sarcoma, scintigraphy, soft-tissue, thallium-201, tumor",
author = "Naoaki Kawakami and Toshiyuki Kunisada and Shuhei Sato and Yuki Morimoto and Masato Tanaka and Tsuyoshi Sasaki and Shinsuke Sugihara and Hiroyuki Yanai and Susumu Kanazawa and Toshihumi Ozaki",
year = "2011",
month = "11",
doi = "10.1097/RLU.0b013e3182177407",
language = "English",
volume = "36",
pages = "982--986",
journal = "Clinical Nuclear Medicine",
issn = "0363-9762",
publisher = "Lippincott Williams and Wilkins",
number = "11",

}

TY - JOUR

T1 - Thallium-201 scintigraphy is an effective diagnostic modality to distinguish malignant from benign soft-tissue tumors

AU - Kawakami, Naoaki

AU - Kunisada, Toshiyuki

AU - Sato, Shuhei

AU - Morimoto, Yuki

AU - Tanaka, Masato

AU - Sasaki, Tsuyoshi

AU - Sugihara, Shinsuke

AU - Yanai, Hiroyuki

AU - Kanazawa, Susumu

AU - Ozaki, Toshihumi

PY - 2011/11

Y1 - 2011/11

N2 - Background: The aim of this study is to evaluate whether thallium-201 (201-Tl) scintigraphy can differentiate malignant from benign soft-tissue tumors. Methods: Between April 1995 and December 2005, 192 patients with soft-tissue tumors (85 malignant and 107 benign) underwent 201-Tl scintigraphy before treatment. Isotope uptake was used as a proxy for tumor-to-background ratio (TBR). The accuracy of TBR on early and delayed imaging was evaluated using the Mann-Whitney U and χ 2 tests. Results: There was a statistically significant difference in mean TBR on early and delayed imaging of malignant and benign soft-tissue tumors (124% ± 109% vs. 22% ± 42%, and 82% ± 83% vs. 12% ± 25%, P <0.0001). A TBR cutoff of 20% indicated the probability of malignancy on early and delayed imaging (82% sensitivity and 77% specificity; 82% sensitivity and 84% specificity, P <0.0001). Well-differentiated liposarcomas showed low isotope accumulation, while pigmented villonodular synovitis and giant cell tumors of the tendon sheath showed high isotope accumulation. Conclusions: Thallium-201 scintigraphy can distinguish malignant from benign tumors with relatively high accuracy. With the exception of low grade liposarcomas and locally aggressive benign tumors, 201-Tl scintigraphy may be an effective diagnostic modality to differentiate malignant from benign soft-tissue tumors.

AB - Background: The aim of this study is to evaluate whether thallium-201 (201-Tl) scintigraphy can differentiate malignant from benign soft-tissue tumors. Methods: Between April 1995 and December 2005, 192 patients with soft-tissue tumors (85 malignant and 107 benign) underwent 201-Tl scintigraphy before treatment. Isotope uptake was used as a proxy for tumor-to-background ratio (TBR). The accuracy of TBR on early and delayed imaging was evaluated using the Mann-Whitney U and χ 2 tests. Results: There was a statistically significant difference in mean TBR on early and delayed imaging of malignant and benign soft-tissue tumors (124% ± 109% vs. 22% ± 42%, and 82% ± 83% vs. 12% ± 25%, P <0.0001). A TBR cutoff of 20% indicated the probability of malignancy on early and delayed imaging (82% sensitivity and 77% specificity; 82% sensitivity and 84% specificity, P <0.0001). Well-differentiated liposarcomas showed low isotope accumulation, while pigmented villonodular synovitis and giant cell tumors of the tendon sheath showed high isotope accumulation. Conclusions: Thallium-201 scintigraphy can distinguish malignant from benign tumors with relatively high accuracy. With the exception of low grade liposarcomas and locally aggressive benign tumors, 201-Tl scintigraphy may be an effective diagnostic modality to differentiate malignant from benign soft-tissue tumors.

KW - sarcoma

KW - scintigraphy

KW - soft-tissue

KW - thallium-201

KW - tumor

UR - http://www.scopus.com/inward/record.url?scp=80053964160&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=80053964160&partnerID=8YFLogxK

U2 - 10.1097/RLU.0b013e3182177407

DO - 10.1097/RLU.0b013e3182177407

M3 - Article

VL - 36

SP - 982

EP - 986

JO - Clinical Nuclear Medicine

JF - Clinical Nuclear Medicine

SN - 0363-9762

IS - 11

ER -