Thalidomide as a nitric oxide synthase inhibitor and its structural development

Rumiko Shimazawa; Hiroko Sano; Aya Tanatani; Hiroyuki Miyachi; Yuichi Hashimoto

doi:10.1248/cpb.52.498

Thalidomide as a nitric oxide synthase inhibitor and its structural development

Rumiko Shimazawa, Hiroko Sano, Aya Tanatani, Hiroyuki Miyachi, Yuichi Hashimoto

Faculty of Pharmaceutical Sciences

Research output: Contribution to journal › Article › peer-review

39 Citations (Scopus)

Abstract

Thalidomide has been found to exhibit weak nitric oxide synthase (NOS)-inhibitory activity. Structural development studies of thalidomide showed that some N-2,6-dimethylphenylhomophthalimide analogs possess NOS-inhibiting activity.

Original language	English
Pages (from-to)	498-499
Number of pages	2
Journal	Chemical and Pharmaceutical Bulletin
Volume	52
Issue number	4
DOIs	https://doi.org/10.1248/cpb.52.498
Publication status	Published - Apr 2004

Keywords

Inhibitor
Nitric oxide synthase (NOS)
Structural development
Thalidomide

ASJC Scopus subject areas

Chemistry(all)
Drug Discovery

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10.1248/cpb.52.498

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abstract = "Thalidomide has been found to exhibit weak nitric oxide synthase (NOS)-inhibitory activity. Structural development studies of thalidomide showed that some N-2,6-dimethylphenylhomophthalimide analogs possess NOS-inhibiting activity.",

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author = "Rumiko Shimazawa and Hiroko Sano and Aya Tanatani and Hiroyuki Miyachi and Yuichi Hashimoto",

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AU - Sano, Hiroko

AU - Tanatani, Aya

AU - Miyachi, Hiroyuki

AU - Hashimoto, Yuichi

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KW - Structural development

KW - Thalidomide

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Thalidomide as a nitric oxide synthase inhibitor and its structural development

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

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