Thalidomide as a nitric oxide synthase inhibitor and its structural development

Rumiko Shimazawa, Hiroko Sano, Aya Tanatani, Hiroyuki Miyachi, Yuichi Hashimoto

Research output: Contribution to journalArticle

37 Citations (Scopus)

Abstract

Thalidomide has been found to exhibit weak nitric oxide synthase (NOS)-inhibitory activity. Structural development studies of thalidomide showed that some N-2,6-dimethylphenylhomophthalimide analogs possess NOS-inhibiting activity.

Original languageEnglish
Pages (from-to)498-499
Number of pages2
JournalChemical and Pharmaceutical Bulletin
Volume52
Issue number4
DOIs
Publication statusPublished - Apr 1 2004

Keywords

  • Inhibitor
  • Nitric oxide synthase (NOS)
  • Structural development
  • Thalidomide

ASJC Scopus subject areas

  • Chemistry(all)
  • Drug Discovery

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