Thalidomide as a nitric oxide synthase inhibitor and its structural development

Rumiko Shimazawa, Hiroko Sano, Aya Tanatani, Hiroyuki Miyachi, Yuichi Hashimoto

Research output: Contribution to journalArticle

36 Citations (Scopus)

Abstract

Thalidomide has been found to exhibit weak nitric oxide synthase (NOS)-inhibitory activity. Structural development studies of thalidomide showed that some N-2,6-dimethylphenylhomophthalimide analogs possess NOS-inhibiting activity.

Original languageEnglish
Pages (from-to)498-499
Number of pages2
JournalChemical and Pharmaceutical Bulletin
Volume52
Issue number4
DOIs
Publication statusPublished - Apr 2004
Externally publishedYes

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Thalidomide
Nitric Oxide Synthase

Keywords

  • Inhibitor
  • Nitric oxide synthase (NOS)
  • Structural development
  • Thalidomide

ASJC Scopus subject areas

  • Drug Discovery
  • Organic Chemistry
  • Chemistry(all)
  • Pharmacology

Cite this

Thalidomide as a nitric oxide synthase inhibitor and its structural development. / Shimazawa, Rumiko; Sano, Hiroko; Tanatani, Aya; Miyachi, Hiroyuki; Hashimoto, Yuichi.

In: Chemical and Pharmaceutical Bulletin, Vol. 52, No. 4, 04.2004, p. 498-499.

Research output: Contribution to journalArticle

Shimazawa, R, Sano, H, Tanatani, A, Miyachi, H & Hashimoto, Y 2004, 'Thalidomide as a nitric oxide synthase inhibitor and its structural development', Chemical and Pharmaceutical Bulletin, vol. 52, no. 4, pp. 498-499. https://doi.org/10.1248/cpb.52.498
Shimazawa, Rumiko ; Sano, Hiroko ; Tanatani, Aya ; Miyachi, Hiroyuki ; Hashimoto, Yuichi. / Thalidomide as a nitric oxide synthase inhibitor and its structural development. In: Chemical and Pharmaceutical Bulletin. 2004 ; Vol. 52, No. 4. pp. 498-499.
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