Thalidomide as a multitarget drug and its application as a template for drug design

Yuichi Hashimoto, Aya Tanatani, Kazuo Nagasawa, Hiroyuki Miyachi

Research output: Contribution to journalReview article

36 Citations (Scopus)

Abstract

Thalidomide is a hypnotic/sedative drug which was withdrawn from the market because of teratogenicity. However, it has been established to be useful for the treatment of various diseases, including Hansen's disease and various cancers. Thalidomide elicits a wide range of pharmacological effects, including anti-cachexia, antitumor-promoting, antiangiogenic, immunosuppressing, antiviral, hypoglycemic, cell differentiation-inducing and antimetastatic activities. It appears to be a multitarget drug, and hypothetical target events/molecules of thalidomide include TNF-α production, nuclear androgen receptor, cyclooxygenases, nuclear retinoic acid receptor, aminopeptidases and α-glucosidase. Specific and potent compounds acting on each of these target phenomena/molecules have been prepared by appropriate modification of the thalidomide structure and are expected to be superior lead compounds for novel immunomodulators, antiangiogenic agents and antitumor-promoting agents.

Original languageEnglish
Pages (from-to)383-391
Number of pages9
JournalDrugs of the Future
Volume29
Issue number4
DOIs
Publication statusPublished - Apr 1 2004

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)

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