Testosterone modulates serum leptin concentrations in a male patient with hypothalamic hypogonadism

T. Ogura; K. Tobe; Y. Mimura; F. Otsuka; T. Yamauchi; A. Imai; C. Tsukamoto; Y. Iwasaki; K. Matsuura

doi:10.1007/BF03343716

Testosterone modulates serum leptin concentrations in a male patient with hypothalamic hypogonadism

T. Ogura, K. Tobe, Y. Mimura, F. Otsuka, T. Yamauchi, A. Imai, C. Tsukamoto, Y. Iwasaki, K. Matsuura

Research output: Contribution to journal › Article › peer-review

5 Citations (Scopus)

Abstract

Serial measurements of body mass index (BMI), serum concentrations of testosterone (T), estradiol (E) and leptin (L) were performed before and after gonadotropin (Gn) therapy in an 18-year-old male subject (BMI 25.4 kg/m²) with idiopathic hypothalamic hypogonadism (IHH). We also measured the BMI and serum concentrations of L in 99 age-matched healthy subjects. Serum L correlated significantly with BMI in control subjects (r=0.84, p<0.0001). Baseline serum concentrations of L in our case were markedly high and both T and E were very low, but Gn therapy resulted in a gradual decrease in L and improvement in T and E, finally reaching the control levels of BMI-matched subjects. Our results demonstrate that T is a powerful negative modulator of serum L independent of BMI in conditions associated with low T levels, such as IHH. (C)2000, Editrice Kurtis.

Original language	English
Pages (from-to)	246-250
Number of pages	5
Journal	Journal of endocrinological investigation
Volume	23
Issue number	4
DOIs	https://doi.org/10.1007/BF03343716
Publication status	Published - 2000

Keywords

Estradiol
Hypogonadotropic hypogonadism
Leptin
Male adolescent
Obesity
Testosterone

ASJC Scopus subject areas

Endocrinology, Diabetes and Metabolism
Endocrinology

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10.1007/BF03343716

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title = "Testosterone modulates serum leptin concentrations in a male patient with hypothalamic hypogonadism",

abstract = "Serial measurements of body mass index (BMI), serum concentrations of testosterone (T), estradiol (E) and leptin (L) were performed before and after gonadotropin (Gn) therapy in an 18-year-old male subject (BMI 25.4 kg/m2) with idiopathic hypothalamic hypogonadism (IHH). We also measured the BMI and serum concentrations of L in 99 age-matched healthy subjects. Serum L correlated significantly with BMI in control subjects (r=0.84, p<0.0001). Baseline serum concentrations of L in our case were markedly high and both T and E were very low, but Gn therapy resulted in a gradual decrease in L and improvement in T and E, finally reaching the control levels of BMI-matched subjects. Our results demonstrate that T is a powerful negative modulator of serum L independent of BMI in conditions associated with low T levels, such as IHH. (C)2000, Editrice Kurtis.",

keywords = "Estradiol, Hypogonadotropic hypogonadism, Leptin, Male adolescent, Obesity, Testosterone",

author = "T. Ogura and K. Tobe and Y. Mimura and F. Otsuka and T. Yamauchi and A. Imai and C. Tsukamoto and Y. Iwasaki and K. Matsuura",

year = "2000",

doi = "10.1007/BF03343716",

language = "English",

volume = "23",

pages = "246--250",

journal = "Journal of Endocrinological Investigation",

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T1 - Testosterone modulates serum leptin concentrations in a male patient with hypothalamic hypogonadism

AU - Ogura, T.

AU - Tobe, K.

AU - Mimura, Y.

AU - Otsuka, F.

AU - Yamauchi, T.

AU - Imai, A.

AU - Tsukamoto, C.

AU - Iwasaki, Y.

AU - Matsuura, K.

PY - 2000

Y1 - 2000

N2 - Serial measurements of body mass index (BMI), serum concentrations of testosterone (T), estradiol (E) and leptin (L) were performed before and after gonadotropin (Gn) therapy in an 18-year-old male subject (BMI 25.4 kg/m2) with idiopathic hypothalamic hypogonadism (IHH). We also measured the BMI and serum concentrations of L in 99 age-matched healthy subjects. Serum L correlated significantly with BMI in control subjects (r=0.84, p<0.0001). Baseline serum concentrations of L in our case were markedly high and both T and E were very low, but Gn therapy resulted in a gradual decrease in L and improvement in T and E, finally reaching the control levels of BMI-matched subjects. Our results demonstrate that T is a powerful negative modulator of serum L independent of BMI in conditions associated with low T levels, such as IHH. (C)2000, Editrice Kurtis.

AB - Serial measurements of body mass index (BMI), serum concentrations of testosterone (T), estradiol (E) and leptin (L) were performed before and after gonadotropin (Gn) therapy in an 18-year-old male subject (BMI 25.4 kg/m2) with idiopathic hypothalamic hypogonadism (IHH). We also measured the BMI and serum concentrations of L in 99 age-matched healthy subjects. Serum L correlated significantly with BMI in control subjects (r=0.84, p<0.0001). Baseline serum concentrations of L in our case were markedly high and both T and E were very low, but Gn therapy resulted in a gradual decrease in L and improvement in T and E, finally reaching the control levels of BMI-matched subjects. Our results demonstrate that T is a powerful negative modulator of serum L independent of BMI in conditions associated with low T levels, such as IHH. (C)2000, Editrice Kurtis.

KW - Estradiol

KW - Hypogonadotropic hypogonadism

KW - Leptin

KW - Male adolescent

KW - Obesity

KW - Testosterone

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