Testosterone modulates serum leptin concentrations in a male patient with hypothalamic hypogonadism

T. Ogura, K. Tobe, Y. Mimura, F. Otsuka, T. Yamauchi, A. Imai, C. Tsukamoto, Y. Iwasaki, K. Matsuura

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Serial measurements of body mass index (BMI), serum concentrations of testosterone (T), estradiol (E) and leptin (L) were performed before and after gonadotropin (Gn) therapy in an 18-year-old male subject (BMI 25.4 kg/m2) with idiopathic hypothalamic hypogonadism (IHH). We also measured the BMI and serum concentrations of L in 99 age-matched healthy subjects. Serum L correlated significantly with BMI in control subjects (r=0.84, p<0.0001). Baseline serum concentrations of L in our case were markedly high and both T and E were very low, but Gn therapy resulted in a gradual decrease in L and improvement in T and E, finally reaching the control levels of BMI-matched subjects. Our results demonstrate that T is a powerful negative modulator of serum L independent of BMI in conditions associated with low T levels, such as IHH. (C)2000, Editrice Kurtis.

Original languageEnglish
Pages (from-to)246-250
Number of pages5
JournalJournal of endocrinological investigation
Volume23
Issue number4
DOIs
Publication statusPublished - 2000

Keywords

  • Estradiol
  • Hypogonadotropic hypogonadism
  • Leptin
  • Male adolescent
  • Obesity
  • Testosterone

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

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