Teratocarcinoma F9 cells induced to differentiate with sodium butyrate produce both tissue‐type and urokinase‐type plasminogen activators

Masashi Takeda, Mitsuko Kosaka, Yukio Nishina, Ken Sawada, Keishi Matsumoto, Yoshitake Nishimune

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Sodium butyrate (NaB) can induce teratocarcinoma cell differentiation as retinoic acid (RA). However, the function of these two agents seems to be a little different [Kosaka et al., Exp Cell Res, 192 : 46–51, 1991]. F9 cells treated with NaB synthesize both tissue‐type (tPA) and urokinase‐type (uPA) plasminogen activator, though RA induces only tPA production. Urokinase‐type PA is demonstrated to exist in association with membrane and to localize its activity to the close environment of the cell surface. This may cause the specific cell morphology and characteristics of differentiated F9 cells induced with NaB.

Original languageEnglish
Pages (from-to)284-289
Number of pages6
JournalJournal of Cellular Biochemistry
Volume49
Issue number3
DOIs
Publication statusPublished - Jul 1992

Keywords

  • embryonal carcinoma
  • retinoic acid
  • stem cell

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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