Abstract
Mechanical stress is one of the most potent inducer of bone formation. The mechanism by which cells receive and transduce the signal into osteogenesis, however, remains unknown. Previous studies have demonstrated that mechanical stress causes changes in expression levels of many genes in osteoblasts and osteocytes both in vivo and in vitro. However, none of these changes are specific to bone cells. Moreover it is not clear which types of cells contributed to the increased osteoblasts induced by mechanical stress. The purpose of this study, therefore, was to identify which cells differentiate into osteoblasts and to examine how the expression of genes that are specific to osteogenic cells changes.
| Original language | English |
|---|---|
| Journal | Journal of gravitational physiology : a journal of the International Society for Gravitational Physiology |
| Volume | 7 |
| Issue number | 2 |
| Publication status | Published - 2000 |
| Externally published | Yes |
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Tensile stress induced osteoblast differentiation and osteogenesis in mouse calvarial suture in culture : possible involvement of BMP-4 and other genes. / Kawashima, H.; Ikegame, Mika; Shimomura, J.; Ishibashi, O.; Komori, T.; Noda, T.; Ozawa, H.
In: Journal of gravitational physiology : a journal of the International Society for Gravitational Physiology, Vol. 7, No. 2, 2000.Research output: Contribution to journal › Article
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TY - JOUR
T1 - Tensile stress induced osteoblast differentiation and osteogenesis in mouse calvarial suture in culture
T2 - possible involvement of BMP-4 and other genes.
AU - Kawashima, H.
AU - Ikegame, Mika
AU - Shimomura, J.
AU - Ishibashi, O.
AU - Komori, T.
AU - Noda, T.
AU - Ozawa, H.
PY - 2000
Y1 - 2000
N2 - Mechanical stress is one of the most potent inducer of bone formation. The mechanism by which cells receive and transduce the signal into osteogenesis, however, remains unknown. Previous studies have demonstrated that mechanical stress causes changes in expression levels of many genes in osteoblasts and osteocytes both in vivo and in vitro. However, none of these changes are specific to bone cells. Moreover it is not clear which types of cells contributed to the increased osteoblasts induced by mechanical stress. The purpose of this study, therefore, was to identify which cells differentiate into osteoblasts and to examine how the expression of genes that are specific to osteogenic cells changes.
AB - Mechanical stress is one of the most potent inducer of bone formation. The mechanism by which cells receive and transduce the signal into osteogenesis, however, remains unknown. Previous studies have demonstrated that mechanical stress causes changes in expression levels of many genes in osteoblasts and osteocytes both in vivo and in vitro. However, none of these changes are specific to bone cells. Moreover it is not clear which types of cells contributed to the increased osteoblasts induced by mechanical stress. The purpose of this study, therefore, was to identify which cells differentiate into osteoblasts and to examine how the expression of genes that are specific to osteogenic cells changes.
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UR - http://www.scopus.com/inward/citedby.url?scp=0038322299&partnerID=8YFLogxK
M3 - Article
VL - 7
JO - Journal of gravitational physiology : a journal of the International Society for Gravitational Physiology
JF - Journal of gravitational physiology : a journal of the International Society for Gravitational Physiology
SN - 1077-9248
IS - 2
ER -