TY - JOUR
T1 - Tensile stress induced osteoblast differentiation and osteogenesis in mouse calvarial suture in culture
T2 - possible involvement of BMP-4 and other genes.
AU - Kawashima, H.
AU - Ikegame, M.
AU - Shimomura, J.
AU - Ishibashi, O.
AU - Komori, T.
AU - Noda, T.
AU - Ozawa, H.
PY - 2000/7
Y1 - 2000/7
N2 - Mechanical stress is one of the most potent inducer of bone formation. The mechanism by which cells receive and transduce the signal into osteogenesis, however, remains unknown. Previous studies have demonstrated that mechanical stress causes changes in expression levels of many genes in osteoblasts and osteocytes both in vivo and in vitro. However, none of these changes are specific to bone cells. Moreover it is not clear which types of cells contributed to the increased osteoblasts induced by mechanical stress. The purpose of this study, therefore, was to identify which cells differentiate into osteoblasts and to examine how the expression of genes that are specific to osteogenic cells changes.
AB - Mechanical stress is one of the most potent inducer of bone formation. The mechanism by which cells receive and transduce the signal into osteogenesis, however, remains unknown. Previous studies have demonstrated that mechanical stress causes changes in expression levels of many genes in osteoblasts and osteocytes both in vivo and in vitro. However, none of these changes are specific to bone cells. Moreover it is not clear which types of cells contributed to the increased osteoblasts induced by mechanical stress. The purpose of this study, therefore, was to identify which cells differentiate into osteoblasts and to examine how the expression of genes that are specific to osteogenic cells changes.
UR - http://www.scopus.com/inward/record.url?scp=0038322299&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0038322299&partnerID=8YFLogxK
M3 - Article
C2 - 12697503
AN - SCOPUS:0038322299
VL - 7
SP - P121-122
JO - Journal of gravitational physiology : a journal of the International Society for Gravitational Physiology
JF - Journal of gravitational physiology : a journal of the International Society for Gravitational Physiology
SN - 1077-9248
IS - 2
ER -