Tensile stress induced osteoblast differentiation and osteogenesis in mouse calvarial suture in culture: possible involvement of BMP-4 and other genes.

H. Kawashima, M. Ikegame, J. Shimomura, O. Ishibashi, T. Komori, T. Noda, H. Ozawa

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Mechanical stress is one of the most potent inducer of bone formation. The mechanism by which cells receive and transduce the signal into osteogenesis, however, remains unknown. Previous studies have demonstrated that mechanical stress causes changes in expression levels of many genes in osteoblasts and osteocytes both in vivo and in vitro. However, none of these changes are specific to bone cells. Moreover it is not clear which types of cells contributed to the increased osteoblasts induced by mechanical stress. The purpose of this study, therefore, was to identify which cells differentiate into osteoblasts and to examine how the expression of genes that are specific to osteogenic cells changes.

Original languageEnglish
Pages (from-to)P121-122
JournalJournal of gravitational physiology : a journal of the International Society for Gravitational Physiology
Volume7
Issue number2
Publication statusPublished - Jul 2000
Externally publishedYes

ASJC Scopus subject areas

  • Medicine(all)

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