Tensile stress induced osteoblast differentiation and osteogenesis in mouse calvarial suture in culture

possible involvement of BMP-4 and other genes.

H. Kawashima, Mika Ikegame, J. Shimomura, O. Ishibashi, T. Komori, T. Noda, H. Ozawa

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Mechanical stress is one of the most potent inducer of bone formation. The mechanism by which cells receive and transduce the signal into osteogenesis, however, remains unknown. Previous studies have demonstrated that mechanical stress causes changes in expression levels of many genes in osteoblasts and osteocytes both in vivo and in vitro. However, none of these changes are specific to bone cells. Moreover it is not clear which types of cells contributed to the increased osteoblasts induced by mechanical stress. The purpose of this study, therefore, was to identify which cells differentiate into osteoblasts and to examine how the expression of genes that are specific to osteogenic cells changes.

Original languageEnglish
JournalJournal of gravitational physiology : a journal of the International Society for Gravitational Physiology
Volume7
Issue number2
Publication statusPublished - 2000
Externally publishedYes

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Osteoblasts
Osteogenesis
Sutures
Mechanical Stress
Genes
Osteocytes
Gene Expression
Bone and Bones

Cite this

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T1 - Tensile stress induced osteoblast differentiation and osteogenesis in mouse calvarial suture in culture

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AU - Kawashima, H.

AU - Ikegame, Mika

AU - Shimomura, J.

AU - Ishibashi, O.

AU - Komori, T.

AU - Noda, T.

AU - Ozawa, H.

PY - 2000

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