Temporal change in human nicotinic acetylcholine receptor after smoking cessation: 5IA SPECT study

Marcelo Mamede, Koichi Ishizu, Masashi Ueda, Takahiro Mukai, Yasuhiko Iida, Hidekazu Kawashima, Hidenao Fukuyama, Kaori Togashi, Hideo Saji

Research output: Contribution to journalArticle

56 Citations (Scopus)

Abstract

Nicotinic acetylcholine receptors (nAChRs) are of great interest because they are implicated in various brain functions. They also are thought to play an important role in nicotine addiction of smokers. Chronic (-)-nicotine, a nAChR agonist, treatment in mice and rats elicits a dose-dependent increase in nAChRs in the brain. Upregulation of nAChRs in postmortem human brains of smokers has also been reported. However, changes in nAChRs after cigarette smoking cessation in humans are poorly understood. The aim of this study was to detect the dynamic changes of nAChRs after smoking and smoking cessation in the brains of living subjects. Methods: We performed 5-123I-iodo-A-85380 ( 123I-5IA) SPECT on nonsmokers and smokers (n = 16) who had quit smoking for 4 h, 10 d, and 21 d and calculated and compared distribution volumes (Vt) of 123I-5IA. Results: The binding potential of nAChRs (Vt of 123I-5IA) in the brains of smokers decreased by 33.5% ± 10.5% after 4 h of smoking cessation, increased by 25.7% ± 9.2% after 10 d of smoking cessation, and decreased to the level of nonsmokers after 21 d of smoking cessation. Conclusion: Because the upregulation of the nAChRs of the smokers after chronic exposure of the nicotine was downregulated to the nonsmokers' level by around 21 d after smoking cessation, the upregulation is a temporary effect. The decrease in nicotinic receptors to nonsmoker levels may be the breaking point during the nicotine withdrawal period.

Original languageEnglish
Pages (from-to)1829-1835
Number of pages7
JournalJournal of Nuclear Medicine
Volume48
Issue number11
DOIs
Publication statusPublished - Nov 1 2007
Externally publishedYes

Fingerprint

Nicotinic Receptors
Smoking Cessation
Single-Photon Emission-Computed Tomography
Nicotine
Brain
Up-Regulation
Smoking
Down-Regulation

Keywords

  • I-5IA
  • Human brain
  • Nicotinic acetylcholine receptors
  • Quantitative measurement
  • Smoking withdrawal
  • SPECT

ASJC Scopus subject areas

  • Radiological and Ultrasound Technology

Cite this

Temporal change in human nicotinic acetylcholine receptor after smoking cessation : 5IA SPECT study. / Mamede, Marcelo; Ishizu, Koichi; Ueda, Masashi; Mukai, Takahiro; Iida, Yasuhiko; Kawashima, Hidekazu; Fukuyama, Hidenao; Togashi, Kaori; Saji, Hideo.

In: Journal of Nuclear Medicine, Vol. 48, No. 11, 01.11.2007, p. 1829-1835.

Research output: Contribution to journalArticle

Mamede, M, Ishizu, K, Ueda, M, Mukai, T, Iida, Y, Kawashima, H, Fukuyama, H, Togashi, K & Saji, H 2007, 'Temporal change in human nicotinic acetylcholine receptor after smoking cessation: 5IA SPECT study', Journal of Nuclear Medicine, vol. 48, no. 11, pp. 1829-1835. https://doi.org/10.2967/jnumed.107.043471
Mamede, Marcelo ; Ishizu, Koichi ; Ueda, Masashi ; Mukai, Takahiro ; Iida, Yasuhiko ; Kawashima, Hidekazu ; Fukuyama, Hidenao ; Togashi, Kaori ; Saji, Hideo. / Temporal change in human nicotinic acetylcholine receptor after smoking cessation : 5IA SPECT study. In: Journal of Nuclear Medicine. 2007 ; Vol. 48, No. 11. pp. 1829-1835.
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abstract = "Nicotinic acetylcholine receptors (nAChRs) are of great interest because they are implicated in various brain functions. They also are thought to play an important role in nicotine addiction of smokers. Chronic (-)-nicotine, a nAChR agonist, treatment in mice and rats elicits a dose-dependent increase in nAChRs in the brain. Upregulation of nAChRs in postmortem human brains of smokers has also been reported. However, changes in nAChRs after cigarette smoking cessation in humans are poorly understood. The aim of this study was to detect the dynamic changes of nAChRs after smoking and smoking cessation in the brains of living subjects. Methods: We performed 5-123I-iodo-A-85380 ( 123I-5IA) SPECT on nonsmokers and smokers (n = 16) who had quit smoking for 4 h, 10 d, and 21 d and calculated and compared distribution volumes (Vt) of 123I-5IA. Results: The binding potential of nAChRs (Vt of 123I-5IA) in the brains of smokers decreased by 33.5{\%} ± 10.5{\%} after 4 h of smoking cessation, increased by 25.7{\%} ± 9.2{\%} after 10 d of smoking cessation, and decreased to the level of nonsmokers after 21 d of smoking cessation. Conclusion: Because the upregulation of the nAChRs of the smokers after chronic exposure of the nicotine was downregulated to the nonsmokers' level by around 21 d after smoking cessation, the upregulation is a temporary effect. The decrease in nicotinic receptors to nonsmoker levels may be the breaking point during the nicotine withdrawal period.",
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AU - Mamede, Marcelo

AU - Ishizu, Koichi

AU - Ueda, Masashi

AU - Mukai, Takahiro

AU - Iida, Yasuhiko

AU - Kawashima, Hidekazu

AU - Fukuyama, Hidenao

AU - Togashi, Kaori

AU - Saji, Hideo

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N2 - Nicotinic acetylcholine receptors (nAChRs) are of great interest because they are implicated in various brain functions. They also are thought to play an important role in nicotine addiction of smokers. Chronic (-)-nicotine, a nAChR agonist, treatment in mice and rats elicits a dose-dependent increase in nAChRs in the brain. Upregulation of nAChRs in postmortem human brains of smokers has also been reported. However, changes in nAChRs after cigarette smoking cessation in humans are poorly understood. The aim of this study was to detect the dynamic changes of nAChRs after smoking and smoking cessation in the brains of living subjects. Methods: We performed 5-123I-iodo-A-85380 ( 123I-5IA) SPECT on nonsmokers and smokers (n = 16) who had quit smoking for 4 h, 10 d, and 21 d and calculated and compared distribution volumes (Vt) of 123I-5IA. Results: The binding potential of nAChRs (Vt of 123I-5IA) in the brains of smokers decreased by 33.5% ± 10.5% after 4 h of smoking cessation, increased by 25.7% ± 9.2% after 10 d of smoking cessation, and decreased to the level of nonsmokers after 21 d of smoking cessation. Conclusion: Because the upregulation of the nAChRs of the smokers after chronic exposure of the nicotine was downregulated to the nonsmokers' level by around 21 d after smoking cessation, the upregulation is a temporary effect. The decrease in nicotinic receptors to nonsmoker levels may be the breaking point during the nicotine withdrawal period.

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KW - Smoking withdrawal

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