Abstract
This study characterized phenotypic anomalies of the eustachian tube (ET) and its associated structures in individuals with various chromosomal aberrations (trisomies 13, 18, 21, and 22 and inversion of chromosome 1). The morphological characteristics of the ET and its accessory structures from 10 temporal bone-ET specimens, obtained from 10 individuals with chromosomal aberrations who ranged from the 26th gestational week to 1 year in age, were compared with the same structures from 21 age-matched control subjects without anomalies. The subjects with chromosomal aberrations had a significantly smaller volume of the lateral lamina (LL) of the ET cartilage, a reduced attachment of the tensor veli palatini muscle (TVPM), and, in some cases, a reduced volume of the lumen of the cartilaginous ET. The volume of the medial lamina (ML) of the ET cartilage was normal at birth, but smaller in specimens more than 2 months of age; this finding suggests that the prenatal development was normal, but that the postnatal growth was retarded. The subjects with chromosomal aberrations also displayed a smaller ratio of the volume of the LL to that of the ML (LL/ML ratio). Our results suggest that individuals with various chromosomal aberrations have rather similar anomalies of the ET and its associated structures. We speculate that these anomalies might be closely related to ET dysfunction in these patients.
| Original language | English |
|---|---|
| Pages (from-to) | 722-729 |
| Number of pages | 8 |
| Journal | Annals of Otology, Rhinology and Laryngology |
| Volume | 111 |
| Issue number | 8 |
| Publication status | Published - 2002 |
| Externally published | Yes |
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Keywords
- Anomaly
- Chromosomal aberration
- Eustachian tube
- Histopathology
- Temporal bone
ASJC Scopus subject areas
- Otorhinolaryngology
Cite this
Temporal bone morphometric study on the eustachian tube and its associated structures in patients with chromosomal aberrations. / Miura, Makoto; Sando, Isamu; Balaban, Carey D.; Haginomori, Shin ichi; Orita, Yorihisa.
In: Annals of Otology, Rhinology and Laryngology, Vol. 111, No. 8, 2002, p. 722-729.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Temporal bone morphometric study on the eustachian tube and its associated structures in patients with chromosomal aberrations
AU - Miura, Makoto
AU - Sando, Isamu
AU - Balaban, Carey D.
AU - Haginomori, Shin ichi
AU - Orita, Yorihisa
PY - 2002
Y1 - 2002
N2 - This study characterized phenotypic anomalies of the eustachian tube (ET) and its associated structures in individuals with various chromosomal aberrations (trisomies 13, 18, 21, and 22 and inversion of chromosome 1). The morphological characteristics of the ET and its accessory structures from 10 temporal bone-ET specimens, obtained from 10 individuals with chromosomal aberrations who ranged from the 26th gestational week to 1 year in age, were compared with the same structures from 21 age-matched control subjects without anomalies. The subjects with chromosomal aberrations had a significantly smaller volume of the lateral lamina (LL) of the ET cartilage, a reduced attachment of the tensor veli palatini muscle (TVPM), and, in some cases, a reduced volume of the lumen of the cartilaginous ET. The volume of the medial lamina (ML) of the ET cartilage was normal at birth, but smaller in specimens more than 2 months of age; this finding suggests that the prenatal development was normal, but that the postnatal growth was retarded. The subjects with chromosomal aberrations also displayed a smaller ratio of the volume of the LL to that of the ML (LL/ML ratio). Our results suggest that individuals with various chromosomal aberrations have rather similar anomalies of the ET and its associated structures. We speculate that these anomalies might be closely related to ET dysfunction in these patients.
AB - This study characterized phenotypic anomalies of the eustachian tube (ET) and its associated structures in individuals with various chromosomal aberrations (trisomies 13, 18, 21, and 22 and inversion of chromosome 1). The morphological characteristics of the ET and its accessory structures from 10 temporal bone-ET specimens, obtained from 10 individuals with chromosomal aberrations who ranged from the 26th gestational week to 1 year in age, were compared with the same structures from 21 age-matched control subjects without anomalies. The subjects with chromosomal aberrations had a significantly smaller volume of the lateral lamina (LL) of the ET cartilage, a reduced attachment of the tensor veli palatini muscle (TVPM), and, in some cases, a reduced volume of the lumen of the cartilaginous ET. The volume of the medial lamina (ML) of the ET cartilage was normal at birth, but smaller in specimens more than 2 months of age; this finding suggests that the prenatal development was normal, but that the postnatal growth was retarded. The subjects with chromosomal aberrations also displayed a smaller ratio of the volume of the LL to that of the ML (LL/ML ratio). Our results suggest that individuals with various chromosomal aberrations have rather similar anomalies of the ET and its associated structures. We speculate that these anomalies might be closely related to ET dysfunction in these patients.
KW - Anomaly
KW - Chromosomal aberration
KW - Eustachian tube
KW - Histopathology
KW - Temporal bone
UR - http://www.scopus.com/inward/record.url?scp=0036340788&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0036340788&partnerID=8YFLogxK
M3 - Article
C2 - 12184595
AN - SCOPUS:0036340788
VL - 111
SP - 722
EP - 729
JO - Annals of Otology, Rhinology and Laryngology
JF - Annals of Otology, Rhinology and Laryngology
SN - 0003-4894
IS - 8
ER -