Temporal and spacial changes of BrdU immunoreactivity in amygdala kindling development

K. Sato, M. Iwai, I. Nagano, M. Shoji, Koji Abe

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

To investigate the proliferation of neural stem cells (NSC) in epileptic brain, spaciotemporal expression of immunoreactive bromodeoxyuridine (BrdU) was examined in kindling development of rat. Amygdaloid kindling in partial seizure (PS) was effective in proliferation of NSC detected with BrdU-labeling in subventricular zone (SVZ), but not in dentate gyrus (DG). In SVZ, however, the BrdU-labeling cells decreased at stage generalized seizure (GS). These facts indicate that proliferation of NSC increased with PS and decreased with more severe seizures of GS in SVZ, that such a proliferation did not occur in DG with PS or GS. Thus, the proliferation of NSC was spacially and temporally different between brain regions depending on different kindling stages.

Original languageEnglish
Pages (from-to)593-596
Number of pages4
JournalNeurological Research
Volume24
Issue number6
DOIs
Publication statusPublished - Sep 2002

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Bromodeoxyuridine
Amygdala
Seizures
Neural Stem Cells
Lateral Ventricles
Dentate Gyrus
Brain

Keywords

  • Bromodeoxyuridine (BrdU)
  • Epilepsy
  • Hippocampus
  • Kindling
  • Neurogenesis
  • Subventricular zone

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)

Cite this

Temporal and spacial changes of BrdU immunoreactivity in amygdala kindling development. / Sato, K.; Iwai, M.; Nagano, I.; Shoji, M.; Abe, Koji.

In: Neurological Research, Vol. 24, No. 6, 09.2002, p. 593-596.

Research output: Contribution to journalArticle

Sato, K. ; Iwai, M. ; Nagano, I. ; Shoji, M. ; Abe, Koji. / Temporal and spacial changes of BrdU immunoreactivity in amygdala kindling development. In: Neurological Research. 2002 ; Vol. 24, No. 6. pp. 593-596.
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