Temperature scanning FTIR analysis of interactions between sugar and polymer additive in amorphous sugar-polymer mixtures

Koreyoshi Imamura, Ken Ichi Ohyama, Toru Yokoyama, Yoshinobu Maruyama, Hiroyuki Imanaka, Kazuhiro Nakanishi

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

The impact of a polymer additive (polyvinylpyrrolidone, PVP) on hydrogen bonding in amorphous sugar matrices as well as on the glass transition temperature, Tg, were examined by temperature scanning Fourier transform infrared spectroscopy (TS-FTIR). An amorphous sugar matrix containing PVP was prepared by air-drying an aqueous solution of a sugar-PVP mixture. The hydrogen bonds in the sugar-PVP mixture (sugar-PVP and sugar-sugar hydrogen bonds) were analyzed from the IR peak positions corresponding to the stretching vibration of C=O groups of PVP and O-H groups of the sugar and the temperature dependence of the peak position of the O-H stretching vibration band. The addition of PVP to amorphous mono and disaccharides significantly lowered the extent of hydrogen bond formation while interactions between sugars and the PVP tended to prevent the disruption of hydrogen bonds due to increasing temperature, the magnitude of which was larger for larger oligomers. The T g value for the amorphous sugar was increased by the addition of PVP in many cases. As the size of sugar molecule became larger, the relative magnitude of the increased Tg by PVP to the difference between the Tg values for sugar alone and PVP alone became larger and then reached a certain level; it was slight in the case of glucose. Collectively, these results demonstrate that the magnitude of the impact of PVP on an amorphous sugar matrix strongly vary and are dependent on the types of sugar.

Original languageEnglish
Pages (from-to)519-528
Number of pages10
JournalJournal of Pharmaceutical Sciences
Volume97
Issue number1
DOIs
Publication statusPublished - Jan 2008

Fingerprint

Povidone
Fourier Transform Infrared Spectroscopy
Sugars
Polymers
Scanning
Temperature
Hydrogen bonds
Hydrogen
Vibration
Stretching
Transition Temperature
Disaccharides
Hydrogen Bonding
Glass
Oligomers

Keywords

  • Amorphous
  • Excipients
  • FTIR
  • Glass transition
  • Hydrogen bond
  • Polyvinylpyrrolidone
  • Sugar
  • Thermal analysis

ASJC Scopus subject areas

  • Drug Discovery
  • Organic Chemistry
  • Chemistry(all)
  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science

Cite this

Temperature scanning FTIR analysis of interactions between sugar and polymer additive in amorphous sugar-polymer mixtures. / Imamura, Koreyoshi; Ohyama, Ken Ichi; Yokoyama, Toru; Maruyama, Yoshinobu; Imanaka, Hiroyuki; Nakanishi, Kazuhiro.

In: Journal of Pharmaceutical Sciences, Vol. 97, No. 1, 01.2008, p. 519-528.

Research output: Contribution to journalArticle

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