Abstract
The standard telomeric repeat assay protocol (TRAP) was used to examine telomerase activity in 16 ovarian tumors, 16 cervical carcinomas, 4 uterine tumors, and 3 vaginal tumors. Telomerase activity was detected in 95% of these tumors, 88% of ovarian malignancies, and 100% of cervical, endometrial, and vaginal malignancies. In contrast, telomerase activity was not evident in normal tissues or in benign proliferative lesions, such as leiomyomas, condyloma acuminata, and simple endometrial hyperplasia. These results suggest that telomerase activation is associated with immortalization or malignant transformation of gynecologic tumors.
| Original language | English |
|---|---|
| Pages (from-to) | 171-175 |
| Number of pages | 5 |
| Journal | Gynecologic Oncology |
| Volume | 64 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - Jan 1997 |
| Externally published | Yes |
ASJC Scopus subject areas
- Oncology
- Obstetrics and Gynaecology
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Cite this
Zheng, P. S., Iwasaka, T., Yamasaki, F., Ouchida, M., Yokoyama, M., Nakao, Y., Fukuda, K., Matsuyama, T., & Sugimori, H. (1997). Telomerase activity in gynecologic tumors. Gynecologic Oncology, 64(1), 171-175. https://doi.org/10.1006/gyno.1996.4523