Telomerase activity in gynecologic tumors

Peng Sheng Zheng, Tsuyoshi Iwasaka, Fumio Yamasaki, Mamoru Oouchida, Masatoshi Yokoyama, Yoshifumi Nakao, Koichi Fukuda, Toshitake Matsuyama, Hajime Sugimori

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Abstract

The standard telomeric repeat assay protocol (TRAP) was used to examine telomerase activity in 16 ovarian tumors, 16 cervical carcinomas, 4 uterine tumors, and 3 vaginal tumors. Telomerase activity was detected in 95% of these tumors, 88% of ovarian malignancies, and 100% of cervical, endometrial, and vaginal malignancies. In contrast, telomerase activity was not evident in normal tissues or in benign proliferative lesions, such as leiomyomas, condyloma acuminata, and simple endometrial hyperplasia. These results suggest that telomerase activation is associated with immortalization or malignant transformation of gynecologic tumors.

Original languageEnglish
Pages (from-to)171-175
Number of pages5
JournalGynecologic Oncology
Volume64
Issue number1
DOIs
Publication statusPublished - Jan 1997
Externally publishedYes

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ASJC Scopus subject areas

  • Obstetrics and Gynaecology
  • Oncology

Cite this

Zheng, P. S., Iwasaka, T., Yamasaki, F., Oouchida, M., Yokoyama, M., Nakao, Y., Fukuda, K., Matsuyama, T., & Sugimori, H. (1997). Telomerase activity in gynecologic tumors. Gynecologic Oncology, 64(1), 171-175. https://doi.org/10.1006/gyno.1996.4523