TY - JOUR
T1 - Telomerase activity in gynecologic tumors
AU - Zheng, Peng Sheng
AU - Iwasaka, Tsuyoshi
AU - Yamasaki, Fumio
AU - Ouchida, Mamoru
AU - Yokoyama, Masatoshi
AU - Nakao, Yoshifumi
AU - Fukuda, Koichi
AU - Matsuyama, Toshitake
AU - Sugimori, Hajime
PY - 1997/1
Y1 - 1997/1
N2 - The standard telomeric repeat assay protocol (TRAP) was used to examine telomerase activity in 16 ovarian tumors, 16 cervical carcinomas, 4 uterine tumors, and 3 vaginal tumors. Telomerase activity was detected in 95% of these tumors, 88% of ovarian malignancies, and 100% of cervical, endometrial, and vaginal malignancies. In contrast, telomerase activity was not evident in normal tissues or in benign proliferative lesions, such as leiomyomas, condyloma acuminata, and simple endometrial hyperplasia. These results suggest that telomerase activation is associated with immortalization or malignant transformation of gynecologic tumors.
AB - The standard telomeric repeat assay protocol (TRAP) was used to examine telomerase activity in 16 ovarian tumors, 16 cervical carcinomas, 4 uterine tumors, and 3 vaginal tumors. Telomerase activity was detected in 95% of these tumors, 88% of ovarian malignancies, and 100% of cervical, endometrial, and vaginal malignancies. In contrast, telomerase activity was not evident in normal tissues or in benign proliferative lesions, such as leiomyomas, condyloma acuminata, and simple endometrial hyperplasia. These results suggest that telomerase activation is associated with immortalization or malignant transformation of gynecologic tumors.
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U2 - 10.1006/gyno.1996.4523
DO - 10.1006/gyno.1996.4523
M3 - Article
C2 - 8995569
AN - SCOPUS:0031013130
VL - 64
SP - 171
EP - 175
JO - Gynecologic Oncology
JF - Gynecologic Oncology
SN - 0090-8258
IS - 1
ER -