Telomerase activity in gynecologic tumors

Peng Sheng Zheng; Tsuyoshi Iwasaka; Fumio Yamasaki; Mamoru Ouchida; Masatoshi Yokoyama; Yoshifumi Nakao; Koichi Fukuda; Toshitake Matsuyama; Hajime Sugimori

doi:10.1006/gyno.1996.4523

Telomerase activity in gynecologic tumors

Peng Sheng Zheng, Tsuyoshi Iwasaka, Fumio Yamasaki, Mamoru Ouchida, Masatoshi Yokoyama, Yoshifumi Nakao, Koichi Fukuda, Toshitake Matsuyama, Hajime Sugimori

Research output: Contribution to journal › Article › peer-review

52 Citations (Scopus)

Abstract

The standard telomeric repeat assay protocol (TRAP) was used to examine telomerase activity in 16 ovarian tumors, 16 cervical carcinomas, 4 uterine tumors, and 3 vaginal tumors. Telomerase activity was detected in 95% of these tumors, 88% of ovarian malignancies, and 100% of cervical, endometrial, and vaginal malignancies. In contrast, telomerase activity was not evident in normal tissues or in benign proliferative lesions, such as leiomyomas, condyloma acuminata, and simple endometrial hyperplasia. These results suggest that telomerase activation is associated with immortalization or malignant transformation of gynecologic tumors.

Original language	English
Pages (from-to)	171-175
Number of pages	5
Journal	Gynecologic Oncology
Volume	64
Issue number	1
DOIs	https://doi.org/10.1006/gyno.1996.4523
Publication status	Published - Jan 1997
Externally published	Yes

ASJC Scopus subject areas

Oncology
Obstetrics and Gynaecology

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abstract = "The standard telomeric repeat assay protocol (TRAP) was used to examine telomerase activity in 16 ovarian tumors, 16 cervical carcinomas, 4 uterine tumors, and 3 vaginal tumors. Telomerase activity was detected in 95% of these tumors, 88% of ovarian malignancies, and 100% of cervical, endometrial, and vaginal malignancies. In contrast, telomerase activity was not evident in normal tissues or in benign proliferative lesions, such as leiomyomas, condyloma acuminata, and simple endometrial hyperplasia. These results suggest that telomerase activation is associated with immortalization or malignant transformation of gynecologic tumors.",

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AU - Zheng, Peng Sheng

AU - Iwasaka, Tsuyoshi

AU - Yamasaki, Fumio

AU - Ouchida, Mamoru

AU - Yokoyama, Masatoshi

AU - Nakao, Yoshifumi

AU - Fukuda, Koichi

AU - Matsuyama, Toshitake

AU - Sugimori, Hajime

PY - 1997/1

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